Université Libre de Bruxelles

Treatment of vulvovaginal atrophy using vaginal dilators in addition to usual care : a randomized controlled feasibility trial

To evaluate the feasibility, acceptability, and preliminary efficacy of adding vaginal dilators (VD) to standard therapy for genitourinary syndrome of menopause (GSM). A prospective, randomized pilot trial was conducted at CHU Saint-Pierre, Brussels. Peri- and postmenopausal wome...

Oral health disparities and social determinants in Cameroon: a scoping review

Abstract Background Oral health disparities represent a major but under-prioritized public health challenge in Cameroon. Despite a growing burden of caries, periodontal disease, and tooth loss, oral health remains marginalized within national policy. Understanding the social dete...

Associations Between Types of Imitation and Receptive and Expressive Language Skills in Preschoolers With Autism

Purpose: Imitation and language are associated in autistic children. However, imitation involves various types. This cross-sectional study examined the associations between different imitation abilities and receptive and expressive language skills in autistic preschoolers while c...

Declines in European bumblebee habitat suitability attributable to climate change

Climate change is increasingly implicated in the decline of insect pollinator populations, which provide critical ecosystem services. Isolating its contribution from other co-occurring environmental stresses remains challenging yet crucial for informing conservation strategies an...

A stochastic Lagrangian-based method for nonconvex optimization with nonlinear constraints

Abstract The Augmented Lagrangian Method (ALM) is one of the most common approaches for solving linear and nonlinear constrained problems. However, for nonconvex objectives, the handling of nonlinear inequality constraints remains challenging. In this paper, we propose a stochast...

Full event interpretation with machine-learning-based particle-flow reconstruction in the CMS detector

Abstract The particle-flow (PF) algorithm constructs a global description of each particle collision by producing a comprehensive list of final-state particles, and is central to event reconstruction in the CMS experiment at the CERN LHC. The existing PF implementation relies on...

StereoBed - salvage stereotactic body radiotherapy of the prostate bed for biochemical recurrence after radical prostatectomy: study protocol for a randomized phase II/III trial

In cases of biochemical recurrence (BCR) after radical prostatectomy, salvage radiotherapy (RT) is a well-established standard-of-care treatment. Stereotactic body radiotherapy (SBRT) may offer a shorter treatment duration and favorable radiobiological characteristics, but eviden...

Cognitive Fitness in Ageing (COFITAGE): A Multimodal and Longitudinal Neuroimaging Dataset

Purpose: Brain aging involves interrelated changes in molecular processes, neuroinflammatory mechanisms, brain macro- and microstructure, sleep physiology, and cognition. The 50 to 70 years age range represents a critical transition period, in which these subtle alterations may p...

Animal models of autism spectrum disorder: Bridging biology to behaviour

Abstract The prevalence of autism spectrum disorder (ASD) has risen over the decades, reflecting improved awareness and evolving diagnostic practice. ASD is characterized by clinical and biological heterogeneity, with diverse genetic and environmental risk factors converging on d...

Dual Temporal Reasoning for Human-Centred Early Warning: An Extended BSPG Architecture with Historical-Analogue Confidence Modulation and FEELLLM Felt-State Briefs

This paper introduces BSPG-I / FEELLLM, an extended Black Swan PreCog Generator architecture in which early recognition of risk and meaningful felt-state patterns is formalised as dual temporal reasoning: an endogenous longitudinal-memory axis (participant baseline, past self-rep...

Dual Temporal Reasoning for Human-Centred Early Warning: An Extended BSPG Architecture with Historical-Analogue Confidence Modulation and FEELLLM Felt-State Briefs

This paper introduces BSPG-I / FEELLLM, an extended Black Swan PreCog Generator architecture in which early recognition of risk and meaningful felt-state patterns is formalised as dual temporal reasoning: an endogenous longitudinal-memory axis (participant baseline, past self-rep...

Ten years of clinical and genotypic insights from the Brussels children’s hospital Centre Ressource Autisme: a multidimensional analysis of 1000 autistic patients

Autism is a complex spectrum disorder for which each individual presents a unique combination of symptoms, strengths, and challenges. The interactions between clinical, environmental, and genetic factors in autism remain an area of ongoing research, with many unresolved questions...

Between-session chasing via time of return in online eCasino gambling

Abstract Background and aims Chasing refers to continuing and/or intensifying gambling following losses (loss-chasing) and/or wins (win-chasing). It is commonly captured between sessions, i.e., returning another day/time after losses or wins in prior sessions. Between-session cha...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Enhancement of cytokine-mediated beta-cell apoptosis by free fatty acids

Type 1 diabetes (T1D) results from dysfunction and loss of the insulin-producing pancreatic β cells. The body’s lipid metabolism is strongly regulated during this process but there is a need to understand how this regulation contributes to the β-cell death. Here, we investigated...

Bio-inspired decision making in robot swarms under biases

Abstract To operate autonomously, minimal robot swarms must make timely and reliable collective decisions despite noisy individual sensing and severe constraints on communication, computation, and memory. Achieving this capability could expand their use in applications such as he...

Total Synthesis of Paliurine E by a Highly Convergent Block Approach

ABSTRACT Macrocycles occupy a privileged position in chemistry, biology and medicine, yet their broader exploitation is curtailed by the lack of general, efficient synthetic strategies. Current approaches to macrocycle construction rely largely on stepwise linear assembly, protec...

The bright and dark sides of AI-driven transformation: evidence from Italian firms

Purpose This study examines how firm-level Artificial Intelligence (AI) capabilities are associated with innovation trajectories and firm performance, with particular attention to sustainability-oriented (green) and efficiency-oriented (brown) innovation outcomes. It further inve...

The sweet spot in protein design—Where deep learning meets first principles

This Perspective explores recent methods and prospective ideas for developing hybrid AI-physics-based pipelines for protein and antibody de novo design. We argue that the highest-confidence candidates emerge where deep learning and first-principles models agree, a "sweet spot" th...