Université de Tours

Metabolomics-Guided Bioactivity Evaluation of Disease-Resistant Hybrid Grape Canes for Cosmetic Valorization

Abstract Grape canes constitute a valuable source of diverse polyphenols with recognized cosmetic properties, whose composition varies according to genotype and environmental conditions. Because grapevine resistance to pathogens is partly mediated by the biosynthesis of polypheno...

Recurrent PDGFRB-Mutations in the Epithelioid Variant of Fibrous Papules

Fibrous papule (FP) is a common benign dermal mesenchymal lesion presenting as a solitary, dome-shaped papule mostly located on the nose. The morphologic spectrum is broad, and a number of variants have been described, including hypercellular, clear cell, pigmented, pleomorphic,...

HCV incidence and prevalence trends among people who use drugs in France 2004 to 2023

Abstract Hepatitis C virus (HCV) remains a key public health challenge, particularly among people who use and inject drugs (PWUD, PWID). While direct-acting antivirals (DAA) have revolutionized HCV treatment, meeting the WHO’s 2030 elimination target requires accurate estimation...

Cultivar-Dependent Phytochemical Composition and Cosmetic Potential of Grapevine Callus Cultures

Plant callus cultures are increasingly explored as a source of skin-care ingredients because they enable the production of biomass rich in bioactive metabolites under controlled and reproducible conditions. Callus cultures offer a promising platform for the controlled production...

Collective adsorption of pheromones at the water–air interface

Abstract Understanding the phase behaviour of pheromones and other messaging molecules remains a significant and largely unexplored challenge, even though it plays a central role in chemical communication. Here, we present all-atom molecular dynamics simulations to investigate th...

Advances in left bundle branch area pacing: current evidence, clinical applications, and future perspectives

Introduction Left bundle branch area pacing (LBBAP) resynchronizes the left ventricle through the conduction system rather than through a coronary sinus lead, and is increasingly used as an alternative to biventricular pacing (BVP) for cardiac resynchronization therapy (CRT) in h...

Nonlocal Hamilton–Jacobi Equations on a network with Kirchhoff type conditions

In this article, we consider nonlocal Hamilton–Jacobi Equations on networks with Kirchhoff type conditions for the interior vertices and Dirichlet boundary conditions for the boundary ones: we provide general existence and comparison results in the case when the nonlocal operator...

Probiotics and Risk of Death, Necrotizing Enterocolitis, and Sepsis in Very Preterm Infants

Importance Probiotics are reported to benefit preterm infants, but population-based clinical evidence is limited. In 2020, the Swedish Neonatal Society issued a national recommendation to supplement very preterm infants (28 weeks 0 days’ to 31 weeks 6 days’ gestation) with probio...

Numerical Simulation of Flood Inundation Scenarios Along the Bistrița River, Following a Hypothetical Failure of the Bicaz Dam, Romania

Dam failures are low-probability but high-consequence events which require hydraulic modelling studies for hazard assessment. A hypothetical failure of the 127 m Bicaz gravity Dam, Romania, is investigated using a 2D model developed in HEC-RAS along a 115 km reach of Bistrita Riv...

Cognitive Aging Patterns in Autism: Parallel, Accelerated, or Safeguarded?

Purpose Research in autism has historically focused on childhood, leaving cognitive aging in autistic adults poorly understood. This study investigated whether cognitive aging in autism follows similar or distinct patterns compared to non-autistic adults. We also explored how sub...

Evolutionary dynamics and functional refinement of IGF bioavailability in the vertebrate phylum : focus on IGFBPs

In eutherians, Insulin-like Growth Factor-I (IGF-I) and IGF-II exert insulin-like activity by interacting with type-I receptor. IGF bioavailability is finely regulated by six IGF-Binding Proteins (IGFBPs), IGFBP-1 to -6, which bind IGF-I and -II with high affinity but not insulin...

Organoids and Spheroids for the Design and the Evaluation of Therapeutic Strategies

The design and the evaluation of effective therapeutic modalities have long relied on experimental models that only partially reproduce human physiology [...]

Complex posttraumatic stress disorder and emotion dysregulation: A better understanding of the literature through a systematic review.

OBJECTIVE: This Preferred Reporting Items for Systematic Reviews and Meta-Analyses systematic review aimed to clarify and summarize what is known about the role of emotion dysregulation (ED) in complex posttraumatic stress disorder (CPTSD) from both cross-sectional and longitudin...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

School principals' burnout trajectories: Nature, predictors, and outcomes

This study seeks to achieve a dynamic person-centered understanding of the distinct burnout trajectories observed among 1574 Finnish school principals measured five times over a period of four years. Our results revealed that burnout trajectories corresponded to five main profile...

Pathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts

ACO2 encodes the mitochondrial aconitase, involved in the second step of the tricarboxylic acid cycle. ACO2 variants cause isolated dominant or recessive optic atrophy, characterized by the degeneration of the optic nerves and leading to vision loss with high clinical heterogenei...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...

Tree-based structural equation model for assessing measurement invariance in patient-reported outcome measures

Evidence of measurement invariance (MI) is essential to ensure that scores based on patient-reported outcome measures (PROMs) are comparable across groups or over time. Conventional methods for evaluating MI in PROMs are mostly group-based methods that require that relevant diffe...

Ultrasonic time of flight technique for state of charge estimation in lithium-ion batteries

Accurate State of Charge (SoC) estimation is essential for the safe and reliable operation of lithium-ion batteries. Conventional electrical methods often require complex models and are sensitive to temperature variations and hysteresis effects. This work proposes a non-destructi...