Université de Rennes

Software and Systems Modeling journal celebrates its silver anniversary-a look into the future of modeling

Abstract SoSyM has turned 25. You can even see that on the cover of this dedicated issue. The 25th anniversary of Software and Systems Modeling provides an opportunity to look back—not only at the development of our journal, but also at the evolution of the entire scientific fiel...

An inertial‐based spiral device for separating rare tumor cells from liquid biopsies

Abstract Early detection of primary tumors and metastatic processes increases the success of anti‐tumor therapies and favors good prognoses. Within the current range of methods available to detect the presence of tumors, liquid biopsy is receiving particular attention as it is a...

PRISM with a Pinch of Salt: Simple, Efficient, and Strongly Unforgeable Signatures from Isogenies

Abstract The problem of computing an isogeny of large prime degree from a supersingular elliptic curve of unknown endomorphism ring is assumed to be hard both for classical as well as quantum computers. In this work, we first build a two-round identification protocol whose securi...

A memory of Paleozoic to Quaternary Greenhouse climates recorded in Southern African regolith

Abstract In this article, we explore the potential of iron-rich duricrust regoliths from old erosional anorogenic surfaces to record clues of the long-term continental paleoclimatic evolution. We coupled geochemical, mineralogical and geochronological analyses on iron oxides and...

Coupling Quantum Mechanical Modeling and Molecular Dynamics on Heterogeneous Supercomputers for Studying Distal Mutation Effects on Drug Binding in HIV-1

Abstract Predicting how protein mutations affect drug binding remains a major challenge, particularly when the mutations are distal from the binding site. In this study, we introduce a coupled simulation workflow that combines classical molecular dynamics (MD) with high-throughpu...

Not speaking my language: playback experiments reveal early-orphaned human-reared adult cheetahs lack interest in species-specific vocalizations

Abstract Early adult models, particularly the mother, play an essential role in tuning perception to build the multimodal representation of species-specific social signals, especially in mammals. Therefore, early maternal loss adversely impacts social integration in mammals. More...

Neurofeedback-induced network plasticity in motor and default mode networks correlates with motor recovery after stroke

Abstract Stroke often results in long-term motor impairments, necessitating innovative rehabilitation strategies. Neurofeedback (NF) has emerged as a promising tool to promote functional recovery after stroke by enabling patients to modulate targeted brain activity. In this study...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Synthesis, Photophysical Properties, and Ab Initio Calculations of 2-(2-Hydroxy/methoxyphenyl)pyrimidines Substituted by Sterically Hindered Electron-Donating Groups

Abstract A series of 2-(2-hydroxyphenyl)pyrimidines bearing sterically hindered electron-donating groups (DMAC, PXZ, PTZ, and NPh2), together with their methoxy precursors, were synthesized and investigated by photophysical studies and ab initio calculations. While the hydroxy de...

Uniqueness of Adapted Solutions to Scalar BSDEs with Peano-Type Generators

Abstract. A backward stochastic differential equation (BSDE) with a Peano-type generator is known to have infinitely many solutions when the terminal value is vanishing, and it is shown to have possibly multiple solutions even when the terminal value is not vanishing but nonnegat...

Factors impacting reliance on, and usefulness of, social learning in urban environments

Urban environments provide a range of new environmental conditions that individuals can adapt to. Social learning is thought to be particularly useful in novel or variable environments, such as urban environments. However, there are multiple pathways through which different facto...

Functionality for isomorphism classes of curves and hypersurfaces

We describe algorithms based on invariant theory to solve problems on the geometry of curves, mainly those of genus 2, 3 and 4. New theoretical results building on the first author's PhD thesis are also included.

Axisymmetric gravity currents in porous media under the Darcy–Forchheimer regime

We investigate the spreading of axisymmetric Newtonian gravity currents (GCs) propagating within an infinite, saturated porous medium bounded below by a horizontal impermeable surface. The flow is driven by buoyancy, and the intruding fluid advances due to its higher density rela...

Core open science practices in major medical journals: development of an automatized tool based on a Large Language Model

Background Open science practices are increasingly promoted to improve the transparency and reproducibility of biomedical research, and their large-scale monitoring has been identified as a priority by initiatives such as the UNESCO Recommendation on Open Science. Existing automa...

Strong minimality of triangle functions

In this manuscript, we give a new proof of strong minimality of certain automorphic functions, originally results of Freitag and Scanlon (2017), Casale, Freitag and Nagloo (2020), Blázquez-Sanz, Casale, Freitag and Nagloo (2020). Our proof is shorter and conceptually different th...

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

BACKGROUND: The impact of presumptive coverage policies for work-related mental health disorders has not been extensively studied to date. Using data from the Association of Workers' Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensat...

Combined prognostic value of age at onset and socioeconomic status for long-term survival in metastatic breast cancer

We investigated the combined long-term prognostic value of age at onset and socioeconomic status (SES) on breast cancer overall survival (OS) and metastasis-free survival (MFS) in a cohort of women with metastatic breast cancer. Age at onset was defined as the age at primary diag...

Combined effects of difenoconazole and salinity stress on growth, photosynthetic pigments, and oxidative responses in tomato (Solanum lycopersicum L.)

Environmental contamination by pesticides and salts is a growing agricultural issue, especially in arid and semi-arid regions. Difenoconazole (DIF), a commonly used fungicide, and sodium chloride (NaCl), a widespread salinity stressor, often coexist in soil and water, yet their c...

Accurate MAG reconstruction from a complex soil microbiome through combined short- and HiFi long-reads metagenomics

Abstract Background Advances in high-fidelity long-read (HiFi-LR) sequencing technologies have opened new opportunities to explore the microbial genomic diversity of complex environments, such as soils. While short-read (SR) sequencing has enabled broad insights at the gene level...