Université de Lille

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

The petal identity gene PhDEF has a major binding and regulatory action in the epidermis

ABSTRACT In flowering plants, floral organ identity is specified by the combinatorial action of homeotic genes. While the role of these genes in the early specification of organ identity is well established, their late function throughout floral organ development and in specific...

Isolating the exposomic impact of acute war and displacement within chronic crisis using multimodal, AI-enabled phenotyping

Abstract Wars often unfold within contexts of prolonged instability, yet little is known about how acute conflicts interact with cumulative exposomic adversity to shape mental health processes. Here we studied clinical and subclinical symptoms in a Lebanese sample across three gr...

Cytoplasmic C-Terminal Domain of the MmpL11 Lipid Transporter Is Required for Interaction with Its Co-cistronic Partner MSMEG_0240 in Mycobacterium smegmatis

Abstract MmpL proteins play an important role in the various mechanisms associated with mycobacterial virulence. Identification of interacting protein partners by classical in vitro methods is hampered by the low solubility of these integral membrane proteins. In this study, we u...

Asymmetric bloom lengthening drives high-latitude ocean chlorophyll accumulation imbalance

Terrestrial ecosystems maintain a stable time-allocation budget between growth and senescence, but whether this applies to the ocean remains unclear. Using fused satellite LiDAR and ocean-color data (2007–2022), we show that marine phenology is variable and asymmetric. In high la...

Minimizer Density Revisited: Models and Multiminimizers

High-throughput sequence analysis commonly relies on k-mers and sampling schemes to improve scalability and data locality. Among these, local schemes are widely used and are typically evaluated by their density, the expected fraction of selected positions. Minimizers are the most...

Spatiotemporal terahertz emission nanoscopy of spintronic photocurrent

Capturing ultrafast spin and charge photocurrents on nanoscopic scales is essential for fundamental research in physics and engineering, as well as for future applications, such as novel spin-orbitronic devices. Accessing the fundamental dynamics driven by changes in electronic e...

Reach and engagement in the ECAIL trial targeting socially disadvantaged families across the COVID-19 pandemic and cost-of-living crisis: A mixed-methods implementation study

Background The ECAIL trial, launched in 2017, was designed to evaluate a multicomponent intervention for childhood obesity prevention among hard-to-reach families. At a maternity hospital in Lille, France, healthcare providers screened pregnant women experiencing social vulnerabi...

Super Bloom: Fast and Precise Filter for Streaming k -Mer Queries

Approximate membership query structures are used throughout sequence bioinformatics, from read screening and metagenomic classification to assembly, indexing, and error correction. Among them, Bloom filters remain the default choice. They are not the most efficient structures in...

Validation of a new morphological diagnostic criterion in Mauritian giant tortoises of the genus Cylindraspis ( Cryptodira, Testudinidae ) thanks to paleoproteomics

A collection of Cylindraspis Fitzinger, 1835, subfossils from Mare aux Songes (Mauritius, 4,200 years BP) has recently been described. At the end of this preliminary description, only some of the 216 tortoise bones could be identified using anatomical criteria and the question of...

Treatment of male osteoporosis: a narrative review and position statement by the ECTS Clinical Action Group.

Osteoporosis in men is under-recognized and under-treated despite a substantial disease burden and poorer fracture-related outcomes than in women. Secondary osteoporosis is highly prevalent in men, making the identification and management of underlying causes essential. Bone mine...

MAIA frailty subgroup analysis: long-term follow-up with daratumumab plus lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma

Abstract In MAIA (Daratumumab, lenalidomide, and dexamethasone versus lenalidomide and dexamethasone alone in newly diagnosed multiple myeloma), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) and overall survival (OS) versus Rd in tran...

A spatial scan statistical for categorical, functional data

We have developed and tested a spatial scan statistic for categorical, functional data (CFSS) - a data structure within which current approaches cannot identify spatial clusters. Our methodology combines an encoding scheme for categorical, functional observations with a nonparame...

Conserved hepatic RNA signatures across multiple cohorts reveal novel mechanistic clues for advanced fibrosis in human MASLD.

BACKGROUND: Fibrosis development in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) is a key indicator of disease progression and clinical outcome. Bulk and single-cell transcriptomics on human tissue have advanced understanding of fibrosis progress...

Carnot’s cycle in the making of thermodynamics

International audience

Intra- and inter-specific variability in benthic foraminifera modulates surface sediment reworking

Abstract Bioturbation is a key ecological process that regulates benthic ecosystem functioning, including organic matter remineralization and nutrient regeneration. Despite growing evidence that meiofauna, and benthic foraminifera in particular, contribute to sediment bioturbatio...

End-of-induction circulating tumor DNA outperforms conventional cellular MRD for predicting early progression in follicular lymphoma: an ancillary study of the RELEVANCE randomized trial

In this ancillary study of the RELEVANCE phase III trial (NCT01650701), we performed the first direct intra-patient comparison of circulating tumor DNA (ctDNA)-based versus cellular t( BCL2 / JH ) translocation-based MRD at end of induction (EOI) in 278 patients with advanced FL,...

AI as the New Paint: A Systematic Review of AI as a Design Material

Artificial intelligence (AI) is increasingly influencing creative practice and workflows, with growing research exploring how it can be applied to advance creative work. In parallel, scholars have begun conceptualizing AI as a design material that practitioners can actively shape...

Chaperone-inspired nanobodies enable pathway-selective control of Tau self-assembly

Abstract Selective control of pathogenic protein self-assembly remains a major challenge for intrinsically disordered amyloid-forming proteins such as Tau. Here we show that nanobodies originally raised against the chaperone S100B unexpectedly cross-react with Tau as potential pa...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...