Université de Caen Normandie

Targeting Both Oncogenic Signaling and Dependence Receptor Function is Required to Fully Suppress MET Exon 14 Skipping-Driven tumorigenesis

Abstract Receptor tyrosine kinases (RTKs) classically function as oncogenic drivers that promote survival and proliferation upon ligand binding. A subset of RTKs can also function as dependence receptors, inducing apoptosis in the absence of their ligands. Genetic alterations tha...

Mechanistic insights into Nrf2- and PARP1-mediated radioresistance of glioblastoma stem cells under photon, proton, and carbon ion irradiation: An in vitro study

Glioblastoma multiforme (GBM) exhibits strong resistance to radiotherapy, partly driven by glioblastoma stem-like cells (GSCs) with enhanced redox homeostasis and DNA repair capacity. This study evaluated whether targeting Nrf2-mediated antioxidant signaling and PARP1-dependent D...

Hippocampal volume changes in astronauts and bilateral vestibulopathy patients

Abstract The hippocampus is a particularly plastic and vulnerable brain structure. Given the modulatory role of the vestibular system on hippocampal function, we hypothesized that altered vestibular stimulation associated with prolonged spaceflight could lead to similar hippocamp...

Synergistic Grain Boundary and Phonon Engineering Enables Ultrahigh Thermoelectric Performance in Mg 3 (Sb, Bi) 2 ‐Based Materials

ABSTRACT Thermoelectric Mg 3 (Sb, Bi) 2 has emerged as a rising star in virtue of its promising thermoelectric performance and abundant constituent elements. However, its practical application is hindered by challenges in synthesis and the strong coupling between electrical and t...

Oak masting under climate change: when spatially heterogeneous shifts in flowering phenology reshape pollen limitation

Masting, the irregular, synchronised production of seeds within tree populations, drives forest regeneration and ecosystem dynamics. Its response to climate change may depend on phenological shifts in key reproductive stages, yet this link remains poorly understood. Using 30 yr o...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Homicide at home: setting the agenda for an international collaboration to improve support for children bereaved due to family violence

Background: Bereavement due to fatal family violence (e.g. intimate partner homicide, filicide, parricide, siblicide) is a profoundly disruptive experience for children, with lifelong psychosocial consequences. Although the need for fatal family violence prevention is increasingl...

Adrenaline Use and Request for Emergency Medical Assistance to Manage Food Anaphylaxis

Summary Adrenaline was rarely used, medical assistance being requested in two thirds of anaphylaxis cases. Medical assistance request was less frequent if milder or no cardiovascular anaphylaxis symptoms.

A Lifestyle Behavior Score Predicting Cardiovascular and Other Causes of Death in a Cohort of Middle-Aged Men Followed up Until Extinction

Objective: To create and test in a population study a behavior score, using as far as possible, procedures based on the a posteriori approach. Material and Methods: Data from the Italian Rural Areas (IRAs) of the Seven Countries Study of Cardiovascular Diseases (SCS), comprising...

Quantifying the Gap Between the Local Perceptions of Farming Households and What Experts Say About Climate Change in Haiti and the Dominican Republic

This study quantifies and assesses the gap between the perceptions of 550 farming households on the Caribbean island of Hispaniola and the opinions of 60 regional experts on climate change. This quantification draws on the traditional knowledge of farming households, which is bas...

The Challenge of Adapting a Spatial Accessibility Indicator Developed for Primary Care to the Hemodialysis Context

Background: Access to dialysis facilities greatly affects patients' quality of life and healthcare costs. Transportation alone represents 21% of dialysis-related expenses. Going beyond a simple focus on access, this study aimed to evaluate dialysis care accessibility in France by...

Coprime extensions of indecomposable solutionsto the Yang–Baxter equation

We introduce a method to extend involutive nondegenerate set-theoretic solutions to the Yang-Baxter equation by means of equivariant mappings to graded modules, thus leading to the notion of a twisted extension.Furthermore, we define coprime extensions of solutions and prove that...