Université de Caen Normandie

Prenatal Diagnosis of Distal Aortopulmonary Window by Fetal Cardiac MRI.

IMAGE: Prenatal diagnosis of a distal aortopulmonary window by fetal cardiac magnetic resonance imaging (MRI). CASE SUMMARY: A fetus referred for cardiac MRI because of suboptimal visualization of the great vessels on ultrasound. MRI demonstrated a distal aortopulmonary window wi...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Subcutaneous isatuximab by on-body-injector plus bortezomib, lenalidomide, and dexamethasone in newly diagnosed transplant-ineligible multiple myeloma: ISASOCUT study

Isatuximab–bortezomib–lenalidomide–dexamethasone (Isa-VRd) has emerged as a standard of care for newly diagnosed multiple myeloma transplant-ineligible patients. A subcutaneous (SC) formulation of isatuximab delivered via an on-body injector (OBI) has been developed to facilitate...

Digital solutions for tackling mental health in cancer patients and their families: The ALTHEA project

Despite advances in cancer treatment, the growing global cancer burden underscores the need for comprehensive and supportive care to address the needs of patients and their families. However, access to psycho-oncological support remains often limited across healthcare systems. Th...

Approximation of adelic divisors and equidistribution of small points

Abstract We study the asymptotic distribution of the Galois orbits of generic sequences of algebraic points of small height in a projective variety over a number field. Our main result is a generalization of Yuan’s equidistribution theorem that applies to heights for which Zhang’...

Sexually dimorphic control of excitatory synapse maintenance in ventral hippocampal circuits by Neurexin2α ligand Vstm2b

Abstract Neuronal networks rely on precise synapse formation, maturation, and maintenance orchestrated by synaptic adhesion molecules including α- and β-neurexins (Nrxns). Through unbiased proteomics, we identified Vstm2 family members as α-Nrxn-specific interactors that require...

Toward personalized exergaming: a machine learning-based decision-support approach to cognitive-motor training for long-term care residents with cognitive impairments

Abstract Background Major Neurocognitive Disorder (MND) is characterized by progressive impairments across multiple cognitive domains, leading to reduced autonomy, diminished quality of life, and frequent transition to long-term care facilities. Cognitive-motor exergames, which c...

Pain Management in Older Adults: An Interprofessional Training Approach Assessed by Script Concordance Tests

ABSTRACT Background Optimal perioperative pain management in older adults challenges anesthesiologists due to increased drug sensitivity, altered pharmacokinetics, and limitations of pain assessment tools in cognitively impaired patients. This study evaluated whether a single 60‐...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

Serum GFAP and Age Accurately Distinguish AQP4 ‐ IgG Positive and Double Seronegative NMOSD From MOGAD After a Recent Attack

BACKGROUND: Serum neurofilament-light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are associated with multiple sclerosis (MS) activity. This study aimed to identify patient- and disease-level determinants of sNfL and sGFAP and to evaluate their ability to support dif...

Evolution of the Involvement of Researchers From the University of Caen (France) in Author Identifiers and Social Networks: 2019–2023

ABSTRACT As author identifier services (AIDs) and academic social networks (ASNs) have become increasingly central to scholarly communication in the last decade, it is important to study how these tools are being used and how far researchers are involved in these services. This s...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Low intensity transcranial electrical stimulation for schizophrenia: a triple-blind, randomized, sham-controlled multicenter trial (STIM’Zo)

Persistent symptoms in schizophrenia remain a major therapeutic challenge. Noninvasive electrical stimulation such as transcranial random noise stimulation (tRNS) may alleviate auditory hallucinations and negative symptoms, although existing evidence is limited to case reports an...

Microglia and border-associated macrophages play opposite roles in cerebrovascular and leukocyte responses under systemic inflammation in male mice

Microglia closely associate with the vasculature, but their roles in leukocyte trafficking and cerebral blood flow (CBF) during systemic inflammation are unclear. We show that sustained systemic inflammation leads to altered microglia-vascular interactions, leukocyte recruitment...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Multiscale Symmetry Breaking Enables Tunable Magnetic Anisotropy and Damping in Co 2 FeAl Thin Films

ABSTRACT The ability to simultaneously engineer magnetic stability and spin dissipation remains difficult to realize in scalable metallic thin films. Here, we show that multiscale symmetry breaking provides a route to achieve this control in polycrystalline Co 2 FeAl films withou...

In-host adaptation of Staphylococcus aureus during recurrent prosthetic joint infections: a retrospective longitudinal study

ABSTRACT The aim of this study was to characterize the in vivo evolution of Staphylococcus aureus strains involved in recurrent prosthetic joint infections (PJIs) both phenotypically and genomically. We conducted a monocentric retrospective study in a 1,437-bed French teaching ho...

Anesthesia TeleConsultation for Pediatric preoperative assessment: a large national prospective multicentric study in children (TeleCCCAP)

Background: While interest in pediatric anesthesia teleconsultation is growing, published data remain scarce. This study evaluated the feasibility of anesthesia teleconsultation in children, providing a comprehensive analysis of failure, quality, dedicated time and satisfaction....

Efficient power generation near room temperature in earth-abundant thermoelectric tin sulfide via lattice ordering

The inefficient carrier transport of earth-abundant tin sulfide (SnS), arising from its intrinsically low crystal symmetry, limits its thermoelectric performance at low temperatures. Here, the substitutional Ag+ doping modifies the Na-doped SnS crystal structure by reinforcing la...

Use of cardiac magnetic resonance imaging after hospitalization for acute heart failure: insights from the French nationwide OFICA-2 cohort

Abstract Background Cardiac magnetic resonance (CMR) has a central role in the management of patients with acute heart failure (AHF), but timely access remains heterogeneous. We investigated real-world CMR use in patients hospitalized for AHF and its associations with demographic...