Université d'Angers

Constructive S4 modal logics with the finite birelational frame property

The logics \(\mathsf {CS4} \) and \(\mathsf {IS4} \) are the two leading intuitionistic variants of the modal logic \(\mathsf {S4} \) . Whether the finite model property holds for each of these logics have been long-standing open problems. In this paper, we resolve the first of t...

Will the Capital Markets Union Revive European Growth?

Abstract The EU Capital Markets Union initiative is supposed to further integrate and strengthen European capital markets. However, the Commission’s current agenda fails to harmonize the national markets on one competitive framework. Instead, the Taxonomy Regulation adds a new la...

Evolution of organ failures in allogeneic hematopoietic cell transplantation recipients admitted to the intensive care unit

The prognosis of allogeneic hematopoietic cell transplantation (HCT) recipients admitted to the intensive care unit (ICU) has been historically poor and a time-limited ICU trial may be considered in these patients with uncertain outcomes. How the evolution of organ failures over...

Low-level of mitochondrial DNA alterations during direct-acting antiviral treatment in leukocytes of people who inject drugs living with HCV

Direct-acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, offering high cure rates and favorable safety profiles. However, concerns remain regarding their long-term mitochondrial safety, particularly among vulnerable populations such as people who inj...

Autoimmune and inflammatory diseases associated with T-cell clonal expansion

Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly a...

Changes in students’ self-perceived interprofessional collaborative skills following participation in the student health service program

Interprofessional collaboration is recognized as a key component of effective healthcare systems. In France, the Student Health Service (SHS) is the only mandatory and universal interprofessional training experience in health curricula. However, evidence regarding its impact on i...

Microplastic pollution in Greek seas: Abundance, spatio-temporal dynamics, potential sources and post-storm amplification

Microplastic (MP) pollution represents an increasing threat to coastal and marine ecosystems, yet data from Greek waters remain scarce. This study provides a comprehensive assessment of MP abundance, spatial distribution, polymer composition, and seasonal variability in surface w...

A multiday outdoor festival combining breathwork and cold water immersion is associated with reduced trait anxiety in a naturalistic pre-post study

Abstract Breathwork and cold exposure attract growing public interest, yet little is known about their psychological effects in real-world multi-day formats, and most evidence concerns acute physiological or state-level outcomes rather than more dispositional markers. This natura...

TAIL EXPECTILE ESTIMATION IN THE SEMIPARAMETRIC GENERALIZED PARETO MODEL

Expectiles have received increasing attention as a market risk measure that is both coherent and elicitable. They are defined as a least squares analog to quantiles. Their estimation from heavy-tailed loss data in an extreme value framework is an important and difficult problem,...

Structure–Property Relationships in Donor–Acceptor Systems With Thiophene/Furan π‐Bridges Built by Iterative Oxidation–Decarboxylative Coupling

ABSTRACT This study investigates six donor–π–acceptor (D–π–A) compounds incorporating various π‐conjugated bridges based on bifuran, bithiophene, terfuran, terthiophene, and mixed furan–thiophene sequences. These bridges were synthesized via a key decarboxylative coupling approac...

Pathophysiological insights into ACO2-related inherited disorders through combined functional and multi-omic analyses of ACO2 patient-derived fibroblasts

ACO2 encodes the mitochondrial aconitase, involved in the second step of the tricarboxylic acid cycle. ACO2 variants cause isolated dominant or recessive optic atrophy, characterized by the degeneration of the optic nerves and leading to vision loss with high clinical heterogenei...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Sugar metabolism drives shoot branching by repressing BRC1 through miR319 –targeted TCP4 in Rosa

Abstract The coupling between sugar availability and shoot branching is well established, yet the underlying molecular mechanisms remain largely unknown. Here, using genome-wide profiling, we characterized the sugar signalling pathways by identifying 10 microRNAs (miRNAs) repress...

New informative molecular markers for Alternaria sections Infectoriae and Pseudoalternaria reveal the diversity of lineages infecting wheat and tomato

Fungi in Alternaria sections Infectoriae and Pseudoalternaria are commonly associated with commercially important crops, yet their biosystematics remains difficult to resolve because standard molecular markers often lack sufficient phylogenetic resolution. In this study, we used...

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...

Presumptive Coverage Policies and Workers’ Compensation of Post‐Traumatic Stress Disorder and Other Mental Health Conditions: A Retrospective Time‐Series Study in Canada 2001–2019

BACKGROUND: The impact of presumptive coverage policies for work-related mental health disorders has not been extensively studied to date. Using data from the Association of Workers' Compensation Boards of Canada (AWCBC), our objectives were to describe the evolution of compensat...

Semiclassical tunneling for some 1D Schrödinger operators with complex-valued potentials

We consider the non-selfadjoint, semiclassical Schrödinger operator \mathscr{L}(h) := -h^{2}\partial_{x}^{2}+e^{i\alpha}V , where \alpha \in (-\pi,\pi) and V\colon \R\to \R_{+} is even and vanishes at exactly two (symmetric) non-degenerate minima. We establish a semiclassical tun...

Twisted Kodaira–Spencer Classes and the Inequality of Severi †

Let X be a smooth minimal complex surface of general type subject to the inequality KX2<4χ(OX). The old problem of Severi states that the image of the Albanese map of such a surface is at most a curve. The problem was completely settled by Rita Pardini using the works of Xiao on...

Calpain inhibition prevents high-glucose-induced autophagy blockade and mitochondrial fragmentation in endothelial cells and preserves vascular functions in diabetic mice

Endothelial dysfunction is a major contributor to diabetic vascular complications, yet the mechanisms linking hyperglycemia to impaired endothelial homeostasis remain insufficiently defined. This study identifies calpains as key regulators of endothelial autophagy and mitophagy u...

Adrenaline Use and Request for Emergency Medical Assistance to Manage Food Anaphylaxis

Summary Adrenaline was rarely used, medical assistance being requested in two thirds of anaphylaxis cases. Medical assistance request was less frequent if milder or no cardiovascular anaphylaxis symptoms.