Universität Ulm

Direct Light Storage with Controlled Dark Release in a Bipyridine-Based Covalent Triazine Framework

Abstract Utilizing bifunctional materials capable of direct light-to-charge storage offers an attractive strategy to overcome solar intermittency and enable reliable power supply under dark conditions. Reported bifunctional materials are predominantly based on metal oxides and me...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Identification of a Conserved Temporal Molecular Response Signature to CDK4/6 Inhibition Through Multi-Omics Integration Across Cancer Cell Lines

Treatment of metastatic breast cancer with CDK4/6 inhibitors in combination with hormone ablation is the current first-line standard of care for this indication, and the therapeutic activity of these inhibitors has been demonstrated in various tumor entities. However, the efficac...

Pain characteristics in isolated cervical dystonia: comparison to orthopedic cervical conditions and assessment of botulinum toxin effects

Abstract The objective was to characterize pain and evaluate quality of life (QoL) in cervical dystonia (CD) by comparing pain profiles with patients affected by orthopedic cervical conditions (OCC) and evaluating differences between CD patients with and without head tremor (HT)....

ViTAMIn‐O: Democratizing Computer Vision‐Based Machine Learning for Stem Cell Research

Deep Learning (DL) holds exciting potential in automating the prediction of organoid differentiation results. Nevertheless, current models lack adaptability, openness, and robustness in performance. Additionally, broad employments of predictive models in wet‐lab settings necessit...

War-related and psychological predictors of experiential and physiological fear of war in Germany: findings from a nationally representative survey

Abstract Background Fear of war has emerged as a relevant psychosocial phenomenon in Europe, yet little is known about factors associated with its experiential and physiological dimensions in representative populations. This study examined sociodemographic, war-related, and psych...

Motivated Procrastination

This study provides a rigorous empirical test for motivated memory as a cause for procrastination. In a longitudinal experiment over four weeks, individuals had to complete a cumbersome task of unknown length and receive noisy signals about their assigned workload. Varying scope...

Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work – exploratory post-hoc analyses from a randomized controlled trial

Abstract Background Psychotherapeutic consultation at work (PT-A) is a low-threshold intervention providing early work-focused treatment to employees with symptoms of common mental disorders (CMD). This post-hoc analysis explores whether PT-A, compared with routine care, is assoc...

The lung microbiome in childhood-onset severe neuromuscular disease with respiratory insufficiency: rationale, current evidence, and opportunities for oxford nanopore long-read sequencing

Abstract In severe childhood-onset neuromuscular disease (NMD), ventilatory muscle weakness and ineffective airway clearance drive recurrent infections and chronic colonization that is often culture-negative, polymicrobial, or both. The lung microbiome framework offers a unifying...

Efficacy, safety and circulating tumor cell dynamics in patients treated with Eribulin for HER2-negative advanced breast cancer – results from the phase II DETECT IVb trial

Abstract Background Eribulin is a non-taxane microtubule inhibitor that showed survival benefits for pretreated metastatic breast cancer (MBC) patients. Circulating tumor cells (CTCs) are a prognostic marker, but their role in predicting response to specific MBC treatments is les...

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Cyclosporin A triggers a RIG-I-mediated interferon response through multiple cellular processes

Abstract The development of broad-spectrum antiviral agents is essential for preparedness against emerging viruses with pandemic potential. Cyclosporin A (CsA), a clinically approved immunosuppressant, has been shown to exert antiviral activity against a wide range of viruses. Re...

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections b...

Patients’ and oncologists’ perspectives on shared decision-making and treatment communication in HR+/HER2 − advanced breast cancer: a multicountry survey

Hormone receptor–positive (HR+), human epidermal growth factor receptor 2-negative (HER2−) breast cancer (BC) represents approximately 70% of all cases. In locally advanced or metastatic stages (laBC/mBC), patients’ quality of life (QoL) often worsens, making shared decision-maki...

Fully internally contracted multi-reference configuration interaction methods as efficient tools for the calculation of exchange couplings in organic biradicals

The accurate computation of magnetic exchange interactions in organic biradicals often requires computationally demanding multi-reference configuration interaction (MRCI) methods. However, the large configuration spaces associated with uncontracted approaches limit their applicat...

Super‐Electron‐Donor Polymers: From Monomer Design to Redox Functionality

ABSTRACT The design flexibility of organic materials has enabled numerous applications for energy storage systems. However, few examples of low‐potential p‐type materials for the negative electrode are known in the field of organic batteries, particularly relevant for anion‐rocki...

Representing and Detecting Label Ambiguity in IMU-Based Exercise Evaluation

Home-based physiotherapy is performed without supervision, which leads to incorrect execution and motivates systems that assess movement automatically from inertial measurement units (IMUs). Such systems assign each repetition to a category, yet a relevant share of repetitions fa...

Symbiont effectors modulate plant signalling to increase host stress resilience

Abstract Plant colonizing mutualistic symbionts confer beneficial effects to their hosts, which often includes increased growth, and biotic and abiotic stress resilience. How these benefits are activated on a molecular level is mostly unknown. Here, we describe effector candidate...

FewBodyToolkit.jl: A Julia package for solving quantum few-body problems

Few-body physics explores quantum systems of a small number of particles, bridging the gap between single-particle and many-body regimes. To provide an accessible tool for such studies, we present FewBodyToolkit.jl, a Julia package for quantum few-body simulations. The package su...

Deactivation Neural Ordinary Differential Equation (deactNODE)─Learning Deactivation Kinetics from Integral Data

Abstract Catalyst deactivation critically affects the long-term reactor performance. Thus, the development and parametrization of accurate models to predict the effect of operation conditions is crucial for reactor design. Current models are limited by power-law frameworks or lac...