Universitat Pompeu Fabra

Aggregation framework for continuous digital health measures and application to walking activity data

Abstract No standardized procedures for aggregating continuous digital health measures exist. Using a modified Delphi approach, we developed a framework to standardize the selection of aggregations that provide clinically meaningful, stable values. This was applied to aggregate s...

Palynological study of Erythroxylum (Erythroxylaceae): discrimination of species of forensic/criminological interest under light microscopy

The genus Erythroxylum comprises numerous species of significant ecological, ethnobotanical, and forensic relevance. Some species, such as E. coca and E. novogranatense, are widely known for their use in illicit cocaine production, while others play important roles in traditional...

Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial

Oxaliplatin–fluoropyrimidine combinations are standard adjuvant therapy after radical resection of high-risk stage II and stage III colon cancer but expose many patients to toxicity while failing to prevent relapse in others. PEGASUS was a multicenter, single-arm, phase 2 trial e...

A Philosophy of Crisis? Methodological and Critical Perspectives

Building on Miguel de Beistegui's Crisis: A Critique (2026, Bloomsbury Academic), this forum exchange debates the book's central arguments and their significance for contemporary social, political, and ecological thought. In contrast to philosophers such as Jacques Derrida, who q...

Clinical and Radiological Outcomes of Organising Pneumonia Secondary to COVID-19: A 2-Year Longitudinal Cohort Study

Background: Organising pneumonia secondary to COVID-19 (OP-COVID-19) is a recognised inflammatory complication of SARS-CoV-2 infection. We assessed the 2-year clinical, radiological, and functional evolution of patients hospitalised with OP-COVID-19 and identified factors indepen...

The global cost of automobility

This study quantifies the private and social costs of global automobility and evaluates the potential economic benefits of a transition to shared electric autonomous mobility-as-a-service (E-AV-MaaS). Using comprehensive cost components, including accidents, emissions, air pollut...

Characterization of diseases in temporal comorbidity networks

Comorbidity networks, or disease-disease networks, represent relationships between diseases and can reveal non-random disease associations and multimorbidity structure. These patterns reflect shared pathophysiology, diagnostic pathways, and risk of adverse outcomes. Using large-s...

Predicting SILENT after lithium poisoning: a multicenter cohort study and pragmatic risk stratification model

INTRODUCTION: The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) is a rare but potentially devastating complication of lithium poisoning. Current evidence rests on case reports and small series, leaving its true incidence, risk factors, and follow-up tools po...

Dominant and non-dominant varieties in Catalan: past, present and future

Abstract This article attempts to answer the question “How did educated Catalan-speaking young people and adults from Catalonia, the Balearic Islands and the Valencian Country rate the central Catalan, north-western Catalan and Valencian standard modalities between 2015 and 2024?...

Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.

Background: Prevailing theories propose that autism is characterized by local cortical overconnectivity and long-range underconnectivity, but empirical evidence remains mixed. Methods: = 1009) to examine how functional synchronization profiles dynamically change over time and acr...

Contagion backbone of temporal higher-order networks

Abstract Temporal higher-order networks, where each hyperlink involving a group of nodes is activated or deactivated over time, effectively represent social interactions. They serve as substrates for the spread of epidemics and information. However, the contribution of each hyper...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Cognitive vergence and pupillary responses as functional oculomotor signatures to differentiate AT(N) biological profiles in older adults with mild cognitive impairment

Abstract The locus coeruleus (LC), the earliest site of tau accumulation in Alzheimer’s disease, directly influences pupillary and vergence oculomotor systems. Whether task-evoked oculomotor dynamics can non-invasively differentiate AT(N) profiles, A+T+ (biological Alzheimer’s di...

Violence Against Feminist Advocates: Political Violence and Anti-Gender Politics

Research on violence against women in politics (VAWIP) and research on violence against women activists have made crucial contributions by conceptualizing violence as a gendered phenomenon that targets women in response to their political participation. In these approaches, viole...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance

Abstract Beyond serving as cohesive barriers, epithelia clear apoptotic cells to regulate development, homeostasis and inflammation. How epithelial cells remodel their shape during phagocytosis while preserving tissue integrity, and the role of adhesion receptors in this process,...

First Sounds, Second Language: How Word Onsets Spark Language Co‐Activation in 3‐Year‐Old Bilinguals

ABSTRACT Adult and young bilinguals co‐activate their languages to different degrees, even in entirely monolingual tasks. However, many studies use translation pairs with high phonological overlap (e.g., the English‐GERMAN: “milk”‐“MILCH”), making it difficult to discern the orig...

Neurobiological correlates of longitudinal grey matter volume changes in preclinical Alzheimer’s disease

Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...

A serotonergic mechanism is involved in the pro-cognitive effect of AM6545 treatment in a mouse model of fragile X syndrome

Abstract Fragile X syndrome (FXS) is the principal monogenic syndrome leading to inherited intellectual disability and autism. It is caused by the silencing of FMR1 gene that leads to the loss in the expression of its encoded protein, the fragile X messenger ribonucleoprotein 1 (...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...