Università degli Studi del Piemonte Orientale “Amedeo Avogadro”

The effect of combined lifestyle intervention among long term care facilities: A systematic review

The purpose of this research: Population aging is one of the most significant demographic phenomena of the 21st century. It has led to a growing number of older adults requiring long-term care (LTC), which poses significant challenges for healthcare systems worldwide. Lifestyle m...

Incidence and Risk Factors of Unplanned Emergency Department Transfers From Italian Nursing Homes: A Prospective Multicentre Cohort Study

ABSTRACT Aim To estimate the incidence of unplanned transfers to the emergency department among nursing home residents and to identify resident and organizational factors associated with transfer risk. Design A 12‐month prospective multicentre dynamic cohort study. Methods The st...

Continuous Glucose Monitoring and Automated Insulin Delivery in Infants with Type 1 Diabetes: Real-World Evidence to Support Future International Guidelines

To evaluate efficacy and safety of continuous glucose monitoring (CGM) and automated insulin delivery (AID) in infants. A retrospective multicenter study (13 centers) of 76 children diagnosed with antibody-positive type 1 diabetes before age 2. Outcomes at 12 months were compared...

Multidisciplinary Delphi consensus-based recommendations on the use of image-guided radiotherapy for upper gastrointestinal tumours: an AIRO–AITRO–AIFM study

Abstract Objectives Upper gastrointestinal (GI) malignancies represent one of the most challenging scenarios for image-guided radiotherapy (IGRT). Despite technological advances, clinical practice remains heterogeneous among centres. This national, multidisciplinary Delphi consen...

Prospective analysis of pre-diagnostic untargeted plasma metabolomics and risk of triple-negative breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Triple-negative breast cancer (TNBC) accounts for 10–15% of newly diagnosed breast cancer, and its aetiology is poorly understood compared to other breast cancer subtypes. We applied untargeted metabolomics to identify novel biological pathways associated with TNBC risk and poten...

In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological ch...

Does an Unconventional Source with a High Silica Content (Obsidian) or a High Alumina Content (Bauxite) Affect the Type of Potassium Zeolite Formation? Preliminary Data on Synthetic Products’ Efficiency in Ammonium Removal

In this paper, obsidian (OS) and bauxite (BX) are used to synthesize zeolites via KOH prefusion, followed by a conventional hydrothermal process (HY) or an unconventional vapor-phase crystallization method (VPC) at 90 °C. The results indicate that, due to their chemical and miner...

A Sequential Gut–Pancreas–Liver In Vitro Model to Evaluate the Multi-Target Metabolic Effects of a Nutraceutical Formulation in MASLD-Related Conditions

Background/Objectives: Metabolically dysregulated-associated steatotic liver disease (MASLD) is a complex, multifactorial disorder characterised by hepatic lipid accumulation, insulin resistance, oxidative stress, and dysfunction of the gut–liver axis. Given its intricate pathoph...

Development a novel in silico mRNA vaccine against Clostridium difficile

Clostridium difficile , a toxin-producing bacterium, can lead to conditions ranging from mild diarrhea to severe pseudomembranous colitis. Our research introduces an innovative strategy for developing a multi-epitope mRNA vaccine using in-silico methods targeting proteins involve...

Socioeconomic and Linguistic Factors in Paediatric Type 1 Diabetes: Exploring Glycemic Outcomes, Technology Use, and Residual Beta‐Cell Function in Migrant‐Background Populations

ABSTRACT Aims To investigate associations between migrant status, socioeconomic factors (SES), and residual beta‐cell function and glycemic outcomes in paediatric type 1 diabetes. Methods Retrospective study of 208 children (median [IQR] age 11 [8–14] years; 119 Italian, 89 from...