Universidade Federal do Rio Grande do Sul

L-carnitine modulates molecular responses associated with inflammation, endoplasmic reticulum stress, and neurotrophic signaling in cerebral cortex of neonatal Gcdh−/− mice exposed to glutaric and quinolinic acids

Abstract Glutaric acidemia type 1 (GA I) is caused by deficient activity of glutaryl-CoA dehydrogenase, leading to predominant accumulation of glutaric acid (GA) in the brain. GA I patients present progressive neurological deterioration whose pathophysiology is only partially elu...

Data-Driven Framework Integrating Database Analysis and Bayesian Segmented Quantile Regression to Determine Critical Nutrient Levels in Soil and Leaves of Peach Trees

Fertilization recommendations are frequently proposed by a limited number of calibration experiments conducted in a few regions, with few cultivars. Thus, recommendations concerning nutrients’ critical levels (CLs) and sufficiency ranges (SRs) are not always the most suitable one...

Processes and Patterns of Dolomite Precipitation in Aptian Pre‐Salt Deposits of Santos Basin, Brazil

ABSTRACT The Aptian pre‐salt lacustrine carbonates represent the most significant oil exploration target along the South Atlantic margin. Dolomitization of the Santos Basin Barra Velha Formation (BVF) is critical for reservoir quality, yet its origin, patterns, and evolution rema...

Perspectives on influential factors for the adoption of circular economy practices

Abstract This study aims at contributing to improve understandings of influences that factors may exert on processes of adoption of circular economy (CE) practices by diverse types of organisations. Its propositions offer perspectives structured from categories identified as suit...

Diagenetic Constraints and Impact of Silicification on the Quality of Pre‐Salt Reservoirs of the Sépia Field, Santos Basin, Brazil: Insights From Oxygen Isotopes and Fluid Inclusions

ABSTRACT The conditions and role of silicification in the giant South Atlantic pre‐salt reservoirs have been widely debated recently. Many studies link silicification with degraded reservoir quality, whereas others associate it with increased permeability. Predicting the occurren...

Wine tourism and sustainable regional development: A triple bottom line perspective

Wine tourism is increasingly recognized as a driver for value creation in wineries. The main objective of this research is to analyze the economic, social, and environmental effects of wine tourism at the firm and the regional levels. The methodology used is the case study. The f...

The Role of Wave‐Induced Stress and Drag Coefficients in Offshore Wind Power Production

Abstract This study investigates wind‐wave interactions on offshore wind energy production by comparing a coupled atmosphere‐wave model (WRF‐SWAN) with a stand‐alone atmospheric model (WRF). Using statistical metrics and LiDAR wind measurements from Porto‐Ilha, Brazil, we evaluat...

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood–Brain Barrier Integrity in a Rat Model of Iron Overload

Abstract Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that excessive iron during early postnatal life induces oxidative reactions, lea...

A strong-coupling theory for polarizable symmetrically charged walls with counterions only

A pair of parallel polarizable planar walls at a distance d is considered. The walls are symmetrically charged with a uniform surface charge density, neutralized by mobile point counterions moving between them. The case of repulsive particle images is studied in the strong-coupli...

Ten years of Zika Brazilian outbreak: current epidemiological status, molecular landscape and future concerns

Abstract The Zika virus (ZIKV) promoted global concern in 2015 owing to the outbreak in Brazil related to dramatic neurological complications such as microcephaly. Ten years after the outbreak, this integrative study aimed to analyse the epidemiology of ZIKV in Brazil (2016–2024)...

Ensuring pragmatic and equitable paths forward for hepatitis B virus infection eradication in Latin America

INTRODUCTION: Latin America occupies a paradoxical position in hepatitis B virus (HBV) elimination: aggregate prevalence is low, yet the region remains far from the WHO and PAHO 2030 targets because the burden is structurally concealed within underserved populations and fragmente...

Factors associated with discordance between the patient-reported Rheumatoid Arthritis Disease Activity Index (RADAI) and the Simplified Disease Activity Index (SDAI) concerning the achievement of treat-to-target goals – data from the REAL study

Abstract Background Treat-to-target (T2T) strategies in rheumatoid arthritis (RA) rely on regular assessment of disease activity using validated composite indices, with remission or low disease activity as therapeutic goals. The Simplified Disease Activity Index (SDAI) is widely...

Glucose Transporter Deficiency Syndrome Type 1 (Glut1‐ DS ): New Insights From a Brazilian Cohort of Patients

ABSTRACT Glucose transporter deficiency syndrome type 1 (Glut1‐DS) is a rare neurometabolic disorder caused by pathogenic variants in SLC2A1 , characterized by epilepsy, neurodevelopmental delay, movement disorders, dysarthria, intellectual disability, and postnatal microcephaly....

Revisiting Obesity Definitions: Impact of the 2025 Lancet Commission Criteria on Obesity Prevalence Among People With MASLD

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Iron Isotopes Reveal Fe Export Driven by Change of Tropical Weathering Regime

Abstract Unraveling paleoenvironmental signals recorded in laterites is crucial for quantifying weathering‐driven elemental fluxes at the Earth's surface. New stable iron isotope data (δ 56 Fe), combined with (U‐Th)/He ages in Fe‐oxides from a ferruginous duricrust from French Gu...

A Non-Equilibrium Thermodynamic Framework for Sequential Symmetry Breaking in Driven Complex Fluids

The spontaneous emergence of macroscopic order in driven, far-from-equilibrium complex fluids lacks a generalized framework capable of bridging continuous and discrete symmetry-breaking transitions. In this study, we propose a non-equilibrium phenomenological framework that synth...

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways

Abstract COVID-19 and obesity are complex conditions marked by immune and metabolic dysfunction, with the former still ranking among the leading causes of death from infectious diseases worldwide and the latter reaching pandemic proportions. Clinical evidence consistently shows t...

Intrinsic fire safety margins in reinforced concrete columns and shear walls resulting from ambient-temperature design

Fire design procedures for RC columns and shear walls assume that structures are designed according to ambient-temperature (AT) standards, whose partial safety factors can provide an intrinsic fire safety margin. However, the magnitude of this margin in fire behavior has not yet...

Short-Term Changes, Individual Variability, and Associations with Baseline Physical Performance in Young Male Soccer Players During the Pre-Season

Monitoring physical performance during the pre-season may help coaches and practitioners interpret short-term changes in young soccer players, although group-level analyses may mask individual variability. This observational longitudinal study analyzed short-term changes, individ...

Ozonation Pretreatment to Enhance Coagulation–Flocculation and Biodegradability of Tannery Wastewater

Abstract Tannery wastewater is characterized by high organic loads, low biodegradability, and the presence of recalcitrant compounds, which hinder the efficiency of conventional treatment. In this study, ozonation was evaluated as a pretreatment step to enhance coagulation-floccu...