Institution
Universidade Federal de Minas Gerais
Recent research
- Health & MedicineOpen access
Cardiac aging increases susceptibility to cardiovascular diseases. Cellular senescence may be involved in the development of age-related cardiac diseases. Extensive evidence derived from both clinical and experimental studies suggest that the Type 2 Angiotensin II receptor (AT2R)...
- Health & MedicineOpen access
Kisspeptin has been proposed as a potential therapy for gonadal and gestational metabolic dysfunctions. However, its role in intergenerational reproductive and metabolic dysfunctions of paternal origin remain unknown. Therefore, this study investigated the effects of paternal hyp...
- BiologyOpen access
Objectives We conducted a randomized, double-masked, multicenter clinical trial to evaluate the incremental effect of leucine (LEU)-enriched chocolate supplementation (7.5 g of LEU/d for 12 wk) in addition to an active nutrition intervention on muscle strength in patients undergo...
- BiologyOpen access
Background Snakebite envenoming remains a major neglected tropical disease worldwide, disproportionately affecting rural and socioeconomically vulnerable populations in tropical and subtropical regions. In Peru, snakebite burden is strongly concentrated in Amazonian territories,...
- Health & Medicine
Background: Symptomatic contralateral carotid occlusion (CCO) is considered a high-risk scenario for carotid revascularization, yet the comparative evidence for carotid endarterectomy (CEA) versus carotid artery stenting (CAS) is largely derived from observational data and repeat...
- BiologyOpen access
Dietary nucleotides offer metabolic and antioxidant benefits, yet their direct impact on skeletal myogenesis and structural recovery remains to be fully elucidated. This study evaluated the comparative efficacy of the nucleotide formulation NooQ5 against creatine monohydrate in m...
- BiologyOpen access
Charged alpha-helical peptides: unlocking a powerful new class of ion channel gating modifiers
Abstract Voltage-gated ion channels are commonly modulated by peptide toxins that alter channel gating through direct interactions with pore-forming or voltage-sensing domains. Most well-characterized gating modifiers belong to structurally constrained, disulfide-rich toxin famil...
- Health & MedicineOpen access
Background: Metastatic colorectal cancer (mCRC) is biologically heterogeneous, resulting in variable outcomes despite similar disease burden and treatment. Although metastasectomy offers the only potentially curative option for selected patients, surgical selection remains largel...
- Health & MedicineOpen access
Extracorporeal mechanical wave therapies are widely used for musculoskeletal disorders, but their effects on immature skeletal structures, particularly the growth plate, remain insufficiently understood. This study evaluated the histological and structural effects of repeated rad...
- Health & MedicineOpen access
Abstract Dasatinib (DAS) is a biopharmaceutical classification system (BCS) class II drug that is used orally to treat chronic myelogenous leukemia. However, its very low and pH-dependent aqueous solubility severely limits its oral bioavailability. To address this biopharmaceutic...
- BiologyOpen access
The yeast Spathaspora passalidarum is considered promising for domestication and use in second-generation ethanol production because it ferments xylose and glucose with yields above 70%. However, successful domestication requires not only efficient sugar utilization but also enha...
- Health & MedicineOpen access
Background Saliva has been proposed as a non-invasive biological matrix for cardiovascular biomarker assessment. However, evidence regarding its agreement with blood-based measurements in patients with heart failure remains inconsistent. Objective To assess the presence of NT-pro...
- Engineering & Technology
Abstract This study investigates the mechanical and structural performance of cement-matrix composites reinforced with expanded graphite (EG) at dosages of 0, 0.25, and 0.75 wt% of cement. The physical and chemical properties of the fine aggregates were first characterized to ens...
- BiologyOpen access
Integrated Crop–Livestock–Forest (ICLF) systems have emerged as a key strategy for sustainable agricultural intensification by simultaneously enhancing productivity, ecosystem services, and climate resilience in tropical environments. This review synthesizes current knowledge on...
- Society & EconomicsOpen access
Abstract Background: Sleep disturbances are common after stroke and may negatively impact recovery and quality of life. However, monitoring sleep parameters over time with objective measures remains underreported. Objective: To investigate longitudinal changes in actigraphy-deriv...
- Engineering & TechnologyOpen access
Abstract The increasing demand for sustainable and smart cities has reinforced the need to integrate environmental information into municipal Spatial Data Infrastructures (SDIs) to support urban planning and evidence-based decision-making. Although the Brazilian National Spatial...
- Engineering & TechnologyOpen access
The global energy transition depends heavily on critical minerals, including rare earths, and their extraction increasingly intensifies socio-environmental conflicts in territories marked by a long history of extractive activities. While the energy transition literature has exten...
- Society & EconomicsOpen access
Evolutionary biophysics in Brazil
Abstract Physicists have been fascinated by the biological sciences for many years, but it has also deemed not amenable to be studied by the molecular sciences—for most of recorded history it was actually believed that biology had its own laws, a view that started to erode when t...
- AI & Computing
(Re)Allocation of Police Capacity in Multiple Stages of Efficiency
Crime puts sustained pressure on public security budgets in Latin America, yet police resources are often distributed with little reference to the production capacity of the units that receive them. This study addresses the problem of reallocating police personnel and vehicles ac...
- Society & EconomicsOpen access
Background Intimate partner violence (IPV) is a global public health issue. However, prevalence estimates vary depending on the data source and methodology used. This study aimed to assess methodological differences in estimating the prevalence and age distribution of physical an...