Universidade Estadual de Campinas (UNICAMP)

Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis

The effects of gliflozins on bones of CKD patients on dialysis are unknown. Recently, SGLT2 expression in bone tissue of patients with CKD has been reported. We hypothesized that dapagliflozin may act in bone cells and modulate the Klotho-FGF23 axis. This study analyzed the effec...

Validation of the AO Spine Osteoporotic Fracture Classification—effect of geographical region on reliability and reproducibility

Regional differences affect the reliability of the AO Spine-DGOU Osteoporotic Fracture Classification. European participants showed the highest agreement. This study underscores the need for addressing regional factors to improve the system’s global clinical utility. To evaluate...

Hitherto UnrecognizedIntermolecular Coulombic DecayMechanism in Gases

Abstract Excited atoms and molecules can utilize their excess energy to ionize a neighboring system by a process named interatomic and intermolecular Coulombic decay (ICD). ICD is ultrafast, in the femtosecond regime, and has many modes of appearance. Ample applications of ICD ha...

Matrix-DependentPerformance of β-GlucanComposite Films Functionalized with Phenolics from Passion Fruit SeedWaste

Abstract The valorization of agro-industrial waste for producing sustainable and functional packaging is a key strategy within the circular economy and green chemistry. This study developed active antioxidant edible films by incorporating a phenolic-rich extract from yellow passi...

Strain and Shear Wave Elastography in Thyroid Nodules: Tissue Stiffness as a Complementary Risk Marker for Differentiating Benign, Indeterminate, and Malignant Cytology

ABSTRACT Objective To evaluate the diagnostic performance of shear wave elastography (SWE) and strain elastography (SE) as complementary techniques to conventional B‐mode ultrasound for differentiating benign, indeterminate, and malignant thyroid nodules. Methods This prospective...

Intrinsic fire safety margins in reinforced concrete columns and shear walls resulting from ambient-temperature design

Fire design procedures for RC columns and shear walls assume that structures are designed according to ambient-temperature (AT) standards, whose partial safety factors can provide an intrinsic fire safety margin. However, the magnitude of this margin in fire behavior has not yet...

Grid-Aware Bi-Level Optimization for Truck–Drone Routing: Integrating Grid Feasibility and Shadow Pricing

Electric trucks operating as mobile depots for delivery drones are promising for last-mile logistics, yet fleet electrification makes depot charging a critical issue governed by distribution-grid limits. Existing truck–drone routing formulations omit the electrical network, treat...

Ten-Year Evaluation of Quality Control Indicators in a Brazilian Human Milk Bank

Background: Human milk banks play a critical role in neonatal care by providing donor human milk when maternal milk is unavailable, particularly for preterm and medically vulnerable infants. Despite global expansion, long-term evaluations of discard rates and quality indicators r...

An Explainable Machine Learning Framework for Hypothesis Generation in Biochemical Methane Potential Prediction

Abstract Biochemical methane potential (BMP) assays are widely used to evaluate feedstocks for anaerobic digestion, but they are slow and resource-intensive. This study evaluated whether explainable machine learning can support transparent screening and hypothesis generation from...

Range of dose enhancement factor for gold nanoparticles in radiotherapy using Monte Carlo simulations

Abstract Gold nanoparticles (GNPs) have been widely investigated as radiosensitizers in preclinical radiotherapy studies and are now advancing into clinical trials. To enhance tumour targeting, various molecular vectors are conjugated with GNPs. The localized radiation energy dep...

Smart Coatings Integrating Antimicrobial and Tissue‐Remodeling Functions for Implant Interfaces

AIM: This study aimed to assess the antimicrobial performance and biocompatibility of our drug delivery platform, based on layer-by-layer (LbL) coating incorporating tetracycline (TC) complexed with anionic β-cyclodextrin (TCβCD) and a pH-responsive poly(methacrylic acid) (PMAA)...

Abnormal uterine bleeding, menstrual poverty and the financial burden of menstrual hygiene among Brazilian adolescents: A multicenter cross‐sectional study on health inequities

OBJECTIVE: To describe menstrual period characteristics among Brazilian adolescents, focusing on menstrual patterns, use of sanitary products, and influence of socioeconomic conditions on menstrual health. METHODS: A multicenter cross-sectional study was conducted, including adol...

Color Symmetry Breaking in a Nonlinear Optical Microresonator

ABSTRACT Spontaneous symmetry breaking leads to diverse phenomena across the natural sciences, from the Higgs mechanism in particle physics to superconductors and collective animal behavior. In photonic systems, the symmetry of light states can be broken when two optical fields i...

A Semi‐Discrete Lagrangian‐Eulerian Numerical Scheme for Diffusive‐Dispersive Conservation Laws With Discontinuous Coefficient

ABSTRACT In this work, we present an extension of the semi‐discrete Lagrangian‐Eulerian numerical scheme for diffusive‐dispersive conservation law problems, including a jump discontinuous flux function. As in the one‐dimensional scalar hyperbolic case, the no‐flow curves also org...

Landscape history matters: decoupled responses of plant taxonomic, phylogenetic and functional diversity to intensive agriculture impacts in Cerrado

Loss of woody plants due to intensive agricultural expansion is particularly critical because of their role in ecosystem functions and services, as well as in ecosystem resilience. Therefore, understanding the effects of landscape changes on multiple dimensions of biodiversity (i...

Assertions on an “In Situ” Hydrogen-Powered Ride-On Industrial Floor-Cleaning Scrubber

This study proposes a hydrogen-powered industrial ride-on scrubber (IRoS) investigated by using in situ and on-board H2 production. Technological and financial calculations involving conventional liquefied petroleum gas (LPG), an electric battery, and a hydrogen-powered system in...

Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa

Abstract The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developin...

Comparative Study of Myocutaneous Latissimus Dorsi Flap Breast Reconstruction With Implant Versus Lipofilling: Complication Rates and Risk Factors

BACKGROUND: Breast cancer is the most prevalent malignancy among women globally, and mastectomy often forms a critical part of its treatment. Breast reconstruction is an important aspect of post-mastectomy care, contributing to improved psychological well-being and quality of lif...

Adapting the MasSpec Pen for noninvasive detection of oral cavity squamous cell carcinoma

Oral Cavity Squamous Cell Carcinoma (OCSCC) is a common and deadly form of head and neck cancer which disproportionately afflicts low- and middle-income communities. Since the majority of OCSCC lesions are visible within the oral cavity, visual exam-guided biopsy remains the stan...

A novel gas detector optimisation method combining 2-of-N voting systems, kinetic theory of gases, and exceedance curves to minimise CFD requirements

In the chemical industry, an effective gas detection system is fundamental to safety and risk management to prevent accidental leaks that can lead to major fires and explosions. However, the computational demands of CFD simulations increase decision-making time in a gas detection...