Universidade de Ribeirão Preto

Implications of self-medication among socially vulnerable older adults in the COVID-19 era (2021–2023)

Self-medication is a public health issue, exacerbated by limited healthcare access and the search for quick relief. In Brazil, resource shortages and the COVID-19 pandemic have intensified this behavior, leading to the indiscriminate use of medications among older adults in socia...

Nesting in human-made versus natural cavities affects colony demography and nest architecture in an urban-adapted Neotropical stingless bee

Abstract Habitat loss and urbanisation create challenging environments for many bee species, but some show a remarkable ability to adapt to urban environments, e.g. by nesting in buildings and foraging in gardens or parks. Little is currently known about the consequences of livin...

What Factors Are Associated with Health Literacy Among Family Caregivers of Older Adults?

OBJECTIVES: To identify factors associated with different levels of health literacy among family caregivers of older adults. METHODS: A cross-sectional study was conducted with 150 family caregivers recruited while care recipients attended appointments at a tertiary hospital in t...

Electrophysiological properties of the dorsal motor nucleus of the vagus motoneurones controlling airway mucus secretion in rats

Abstract The parasympathetic efferent innervation to the respiratory airways controls bronchoconstriction and mucus secretion. It is known that the parasympathetic respiratory motoneurones (PRMNs) projecting to the airways are located in the nucleus ambiguus (NA) and dorsal motor...

Cross-Sectional Validation of the NUTRISCORE Screening Tool in Outpatient Oncology Patients

BACKGROUND AND OBJECTIVE: Malnutrition in cancer patients is a complex and multifactorial condition. Validated nutritional screening instruments are essential to ensure diagnostic, accuracy and guide effective nutritional interventions. This study aimed to validate the NUTRISCORE...

Effect of chitosan‐containing desensitizers applied prior to bleaching on the physical properties of enamel

Abstract This in vitro study evaluated the effects of adding chitosan (Chi) to desensitizing agents applied before dental bleaching on enamel properties. Bovine enamel specimens were allocated to seven groups ( n = 12): no treatment (negative control), 2% NaF (positive control),...

Rapid increase of climate extremes reveals new areas of concern in Amazonia

Abstract Amazonia is highly sensitive to climate extremes, yet we lack an Amazon-wide assessment that examines the spatial-temporal changes in these extreme conditions. We address this within seasons and across the hydrological year, using a quantiles approach that integrates the...

Multi-omics analysis reveals Protein Kinase A-associated regulatory remodeling during adaptation of Trichoderma reesei to lignocellulosic substrate

The filamentous fungus Trichoderma reesei is a major industrial source of holocellulolytic enzymes, and its response to complex carbon sources is regulated by nutrient-sensing mechanisms, including the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling pathway...

GENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTSALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE

Aldosterone promotes endothelial dysfunction and cardiovascular injury through mineralocorticoid receptor (MR) activation. Autophagy is essential for endothelial homeostasis, yet its role in aldosterone-mediated vascular dysfunction remains unclear. We tested whether aldosterone...

Differences in corneal biomechanical parameters in normal tension glaucoma versus normotensive glaucoma suspect eyes

Abstract Multicenter retrospective study to evaluate differences in corneal biomechanical parameters provided by Corvis ST to segregate those with normal tension glaucoma (NTG) from glaucoma suspects. We included only newly diagnosed and treatment naïve glaucoma patients. Several...

Neuroprotective effects of ketamine, lamotrigine, and ketoprofen combinations after pars plana vitrectomy and silicone oil injection

Abstract Purpose This experimental study aims to assess the protective impact of combined treatment with ketamine (KTM), lamotrigine (LMT), and ketoprofen (KTP), agents that have demonstrated neuroprotective properties in other experimental contexts, on rabbit retinas in an exper...

Albumin-based cationic nanoemulsion for Protoporphyrin IX delivery in normoxic and hypoxic conditions

Glioblastoma is one of the deadliest cancers in humans, but its treatment is limited by the difficulty drugs have in crossing the blood-brain barrier. Albumin-based nanomaterials have emerged as promising drug delivery systems for neurooncology applications, particularly for the...

Efficacy evaluation of a fermented milk containing inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharomyces cerevisiae to ameliorate the toxic effects of dietary aflatoxins and fumonisins in pigs: a pilot study

Abstract Inactivated microorganisms may reduce mycotoxins’ bioavailability, although in vivo evidence is limited especially in farm animals. This pilot study evaluated whether a fermented milk (FM) containing heat-inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharo...

Antimicrobial coatings for bone regenerative scaffolds: Fabrication strategies and in vitro performance ─ A systematic review

Polymeric scaffolds coated with antimicrobials are promising for the treatment and prevention of osteomyelitis. The literature gap regarding the in vitro viability and applicability of these biomaterials throughout their development pipeline (manufacturing technique and coating m...

Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro

The host immune response plays a central role in determining biomaterial performance, particularly through early macrophage activation dynamics at the tissue–biomaterial interface. This study evaluated the response of THP-1-derived human macrophages cultured on a fibrous extracel...

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system-related mechanisms remain li...

The skill premium across countries in the era of industrial robots and artificial intelligence

How do new technologies affect economic growth and the skill premium? To answer this question, we analyze the impacts of industrial robots and artificial intelligence (AI) across 52 countries using counterfactual simulations. In so doing, we simulate the nested CES production fun...

Factors associated with discordance between the patient-reported Rheumatoid Arthritis Disease Activity Index (RADAI) and the Simplified Disease Activity Index (SDAI) concerning the achievement of treat-to-target goals – data from the REAL study

Abstract Background Treat-to-target (T2T) strategies in rheumatoid arthritis (RA) rely on regular assessment of disease activity using validated composite indices, with remission or low disease activity as therapeutic goals. The Simplified Disease Activity Index (SDAI) is widely...

Circulating Matrix Metalloproteinase Activity and Functional Capacity in Individuals Undergoing Hemodialysis: Exploratory Findings from a Resistance Training Trial

Abstract Purpose To investigate the effects of 24 weeks of resistance training (RT) on pro- and active matrix metalloproteinases (MMPs) and their association with functional performance in end-stage kidney disease (ESKD) patients undergoing hemodialysis. Methods Forty-two ESKD pa...

Adaptive caste allocation modulated by resource distance in Pheidole oxyops

Abstract Caste deployment in social insects reflects trade-offs between resource profitability and spatial costs. We examined how Pheidole oxyops allocates minor and major workers when foraging on carbohydrate- (honey) and protein-rich (sardine) baits placed at two distances (1 m...