Umeå University

Structural and functional insights into a Zn2+-transporting P-type ATPase

Abstract Zinc is essential for life yet toxic in excess, rendering homeostatic control vital for all organisms. Transition metal transporting P-type (P IB -) ATPase proteins are critical for this balance but remain poorly understood at the molecular level. Here, we present the in...

Life stage shifts in salivary microbiota determinants: a cross-sectional study in twins

Abstract Both host genetics and environmental exposures shape the salivary microbiota; however, the relative contributions of these factors from early life to adulthood remain unclear. To address this, we profiled the salivary microbiota of 3387 twin pairs: 939 infant pairs (9–12...

Risk of very serious injuries in Swedish scaffolders - What is an acceptable risk?

Abstract Background This case study estimates the risk of injuries causing death or at least one year’s sick leave due to fall from height among Swedish scaffolders. Findings Cases occurring in 2020 to 2023 were identified from national statistics of accidents at work and statist...

Evidence-Based Insights for the Development and Talent Promotion of Young Athletes in a National Sports Context

Abstract The development of young athletes continues to be a key concern for sports organizations, coaches and policy makers. In Sweden, the public debate on the balance between early talent promotion programs and more inclusive, long-term athlete development models has recently...

Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure–activity relationships among anti-infective indoles

The antibiotic resistance crisis has made the characterization of new anti-infective molecules a pressing matter. Molecules that suppress bacterial growth and survival, virulence, or a combination of these traits all warrant further exploration. Naturally occurring microbe‒host e...

Assessment of drug harm by final-year medical students and ChatGPT – a comparative analysis

Abstract Background Artificial intelligence (AI) is becoming increasingly integrated into medical education and clinical practice. Junior medical staff often act as first-line responders in substance-related presentations, yet their perceptions of drug-related harm are not well c...

A Multimodal Analysis of a Digital Learning Resource – Number Sense Presented Through Different Modes

Abstract Digital learning resources are increasingly used in mathematics education. These learning resources consist of information built on a variety of different modes (i.e., means for communication, e.g., images, written words, mathematical symbols, animations, gestures), whic...

Association of objectively assessed physical activity with immune cell infiltration of the tumor microenvironment in non-metastatic colon cancer

Abstract Purpose Physical activity and immune cell infiltration of the tumor microenvironment are associated with improved prognosis in colon cancer. There is also evidence that physical activity may mobilize immune cells against colon tumors. One possible mechanism behind the po...

Connectivity for square percolation and coarse cubical rigidity in random right-angled Coxeter groups

Abstract We consider a random right-angled Coxeter group (RACG), upper W Subscript normal upper Gamma W Γ $W_{\Gamma}$ , whose presentation graph normal upper Gamma Γ $\Gamma$ is taken to be an Erdős–Rényi random graph, i.e. normal upper Gamma tilde script upper G Subscript n com...

Impact of guidewire caliber on biliary cannulation outcomes: a prospective randomized comparison of 0.025-inch and 0.035-inch guidewires

Background and aim Guidewire-assisted biliary cannulation is the standard technique for endoscopic retrograde cholangiopancreatography (ERCP). Whether guidewire caliber influences cannulation success or post-ERCP pancreatitis (PEP) remains uncertain. We evaluated whether the 0.02...

Assessing ethical competence and ethical climate: development and psychometric testing of the Clinical Ethics Support Measurement Instrument (CES-MI)

Abstract Background Clinical ethics support (CES) is increasingly recognised as essential in healthcare, yet its evaluation remains challenging due to the complexity of CES practices and the latent, psychosocial nature of relevant outcomes. The European Moral Case Deliberation Ou...

Motivating the next generation for primary care in rural Vietnam: insights from medical students and the 585 Policy

Abstract Background Primary health care (PHC) plays a central role in promoting equitable access to health services in Vietnam. However, workforce shortages and unequal distribution of physicians, particularly in remote and disadvantaged areas, remain major challenges. To address...

Systematic Review of the Global Patterns and Determinants of International Student Mobility

ABSTRACT This systematic literature review synthesizes and analyses a corpus of 140 studies on the size and flows of international student mobility (ISM), as well as its determinants. The review confirms a consistent global increase in international students, albeit experienced d...

Metoprolol in Chronic Obstructive Pulmonary Disease without Cardiovascular Disease

BACKGROUND: Beta-blockers may improve outcomes in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease, but randomized trials have been inconclusive. METHODS: This was a multicenter, open-label, pragmatic, phase 4 randomized trial. Patients 40...

Harnessing Nordic microalgae for arsenate biosorption from industrial wastewater

Microalgae-based biosorption represents a promising yet underexplored strategy for arsenic removal from industrial effluents. Here, two Nordic freshwater strains, Chlorella vulgaris 13-1 and Coelastrella sp. 3-4, were assessed for arsenate [As(V)] biosorption from industrial wast...

Validity and reliability of the Turkish version of the ORTO-R in an adolescent clinical sample

Orthorexia nervosa refers to a pathological preoccupation with healthy eating characterized by rigid dietary rules, excessive concern about food purity, and distress when these rules are violated. Despite growing clinical interest, validated instruments for assessing orthorexic t...

Multidentate Ligand Strategy Enables Scalable-Synthesis and Aqueous-Stable CsPbBr3@CsPb2Br5 Perovskite Quantum Dots

Abstract Perovskite quantum dots (PeQDs) show promising potential in the optoelectronic field, but their commercial application is limited by the challenges of aqueous stability and large-scale production. Herein, we tackled both the issues via “one stone,” namely multidentate co...

Effective Tumor Protection by a Tumor-Associated Mucin-1 Glycopeptide-Based Conjugate Vaccine in a Spontaneous Mouse Breast Cancer Model

Abstract Human mucin-1 (MUC1) is an attractive tumor antigen due to its high expression levels on tumor cells and its important roles in tumor development. Due to the aberrant glycosylation of MUC1 on tumor cells, tumor-associated MUC1 (tMUC1) has a shortened O-glycan attached on...

Characteristics of Monozygotic Twins Discordant for Anorexia Nervosa: Comprehensive Risk Evaluation for Anorexia Nervosa in Twins (CREAT) Study

ABSTRACT Objective To characterise the clinical and phenotypic profile of the Comprehensive Risk Evaluation for Anorexia nervosa in Twins (CREAT) cohort, identify candidate risk and illness‐related correlates of AN, and establish a foundation for forthcoming biological, neuroimag...

Towards a deep-learning genomic tool for risk stratification and diagnostic support in sporadic ALS

Abstract Background A variety of common and rare genetic factors have been implicated in the development of amyotrophic lateral sclerosis (ALS), and the evidence is that a genetic component is present in most affected individuals. However, our current understanding of ALS genetic...