Umeå University

Comparison of synthetic and post-synthetic molecular genetic methods of reducing xylan glucuronidation in hybrid aspen for biorefinery applications

Abstract Background The pattern of xylan backbone substitution by 4- O -methylglucuronic acid (mGlcA) and O -acetyl groups generated during biosynthesis in the Golgi apparatus plays a key role in molecular interactions between secondary cell wall polymers in hardwoods, thus regul...

Recognition Loop Dynamics Differentiates m6A-mRNA Reader Domains of YTHDF Proteins

Abstract The three human YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) are highly homologous and recognize the N6-methyladenosine (m6A) modification of mRNA with essentially identical binding modes and affinities. This homogeneity challenges the well-established view th...

Ice Converts Phenols into Persistent Mineral-Bound Polymers

Abstract Freezing fundamentally alters how minerals transform dissolved phenols in cold environments. As water freezes, solutes are excluded from the crystal lattice and concentrated into microscopic pockets of unfrozen liquid, creating reaction conditions far more extreme than t...

Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11c+ atypical memory B-cells after malaria infection

Abstract Atypical B-cells (ABCs) are observed across infections, yet their ontogeny and differentiation remain unclear. Using high-dimensional flow cytometry, single-cell transcriptomics, V(D)J sequencing, and functional assays in samples from individuals with malaria and healthy...

Are Unaudited Firms More Likely to Disregard Tax Payments Prior to Bankruptcy? Small‐Firm Evidence From Sweden

ABSTRACT Proponents of mandatory auditing claim that auditing reduces the risk of tax evasion and that firms disregarding tax payments distort competition because they operate with lower costs than firms that meet their tax obligations. To investigate this, we analyse data from a...

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

Abstract Stiffness is a key mechanical cue of the extracellular matrix (ECM) and biomaterials in tissue engineering. It plays a pivotal role in regulating cellular behaviors and determining cell fate through specific mechanotransduction pathways, including integrin‐mediated signa...

Unpacking the institutional and psychological pathways of community empowerment in cultural heritage governance

Abstract Community empowerment is widely recognized as an effective strategy for improving resident satisfaction in the governance of cultural heritage sites. However, existing studies focus primarily on institutional design and do not systematically explore the underlying psycho...

Meeting lifestyle recommendations among cancer survivors – a cross-sectional descriptive analysis from the Swedish CArdioPulmonary BioImage study (SCAPIS)

PURPOSE: This study aimed to describe lifestyle patterns in relation to recommendations -including physical activity, diet, smoking, alcohol consumption, and sleep quality-among Swedish cancer survivors, stratified by sex and age. METHOD: A descriptive cross-sectional study was p...

The Electrodynamical Nature of Chiral Nanoplasmonics from the Quantum Regime to the Mesoscale

Abstract Chiral plasmonic nanostructures are rapidly emerging as ideal substrates for enantioselective sensing, chiral near-field engineering, and plasmon-assisted catalysis, owing to their exceptional sensitivity to structural handedness. However, whether an atomistic classical...

Using dapagliflozin to reduce symptoms in transthyretin cardiac amyloidosis: An n-of-1 trial series pilot study

Background The role of guideline-directed medical therapy for heart failure (HF) is unclear in transthyretin amyloid cardiomyopathy (ATTR-CM). Dapagliflozin has demonstrated beneficial effects across HF phenotypes, and retrospective studies suggest potential benefit in ATTR-CM; h...

Low Parental Income During Childhood Is Associated With Coronary Atherosclerosis in Midlife

Background Socioeconomic status (SES) is a major risk factor for coronary heart disease, but the life‐course mechanisms and causal pathways remain poorly understood. Therefore, we investigated whether low childhood SES was associated with midlife coronary atherosclerosis and if a...

Temporal dynamics of inflammatory proteins in the pre-symptomatic phase of rheumatoid arthritis related to seroconversion

Abstract Objective Autoimmune processes in rheumatoid arthritis (RA) begin years before clinical symptom onset. This study aimed to analyse inflammation-related proteins in individuals during the pre-symptomatic phase, in relation to healthy controls and patients with early RA, a...

Modifying Electrochemical Doping in Light‐Emitting Electrochemical Cells With Gold Nanoparticles

ABSTRACT Electrochemical doping enables dynamic control of organic semiconductors and underpins technologies such as electrochemical transistors, energy‐storage, bioelectronic, and light‐emitting devices. It is typically governed by the active‐material composition or the applied...

Geographic Variation and Core Signatures of the Root Canal Microbiome: A Cross‐Country Comparative Study

AIM: Root canal infections harbour complex microbial communities that may vary across geographic populations. This study aimed to compare the root canal microbiome across Spain, Sweden, and the USA, identifying key microbial taxa, compositional and functional differences, and coh...

Cross-platform, multi-cohort identification of a caries microbial signature

Objective To identify a robust salivary microbial signature associated with caries using a cross-platform, multi-cohort design.Design Full-length 16S rRNA gene sequencing (ONT) and shotgun metagenomics (MET) were performed in a derivation cohort with matched data (n = 463). Assoc...

Chikungunya virus uses the tetraspanins CD63, CD9, and CD151 to replicate in human synovial fibroblasts

The arthritogenic alphavirus chikungunya virus (CHIKV) causes debilitating long-lasting joint pain. Host factors used by CHIKV to infect joint cells are largely unknown. Here, we evaluated the role of the 19 tetraspanins expressed in primary human synovial fibroblasts in virus in...

Neuropeptide Y levels, social functionality, and cognitive insight in patients with schizophrenia in symptomatic remission: A case-control study

Objective This case-control study aimed to investigate serum neuropeptide Y (NPY) levels in patients with schizophrenia in symptomatic remission and to examine their relationship with social functioning and cognitive insight. Methods Forty patients with schizophrenia in symptomat...

Sexual health after childbirth: a qualitative study of women’s experiences

BACKGROUND: Sexual health is a vital component of overall well-being but receives limited attention in postpartum care. This study aimed to explore how pregnancy and childbirth shape women's experiences of sexual health, and to identify how care and support can be tailored to pro...

Biotechnological adaptation of high-yielding, gibberellin-overproducing Populus trees to seasonal growth patterns

Tree growth is central to both terrestrial ecology and the forestry industry. Biotechnology for inducing the overproduction of phytohormones such as gibberellins (GAs) is a powerful tool for improving tree yield and wood properties. Augumentation of GAs in trees in temperate and...

Learning Nonlinear Finite Element Solution Operators Using Multilayer Perceptrons and Energy Minimization

Abstract. We develop and evaluate a method for learning solution operators to nonlinear problems governed by partial differential equations (PDEs). The approach is based on a finite element discretization and aims at representing the solution operator by a multilayer perceptron t...