Turku University Hospital

Identifying drugs associated with Alzheimer's disease risk using machine learning-assisted signal detection

Background Several Alzheimer's disease (AD) clinical trials currently focus on drug repurposing. Machine learning (ML)-based pharmacoepidemiological approaches may help identify candidate drugs for trials. Objective We applied an ML-based signal detection method to identify drugs...

Epidemiological associations between neurodegeneration and cancer – time to refine our research approach

Cancer and neurodegenerative diseases are devastating aging-related disorders. Epidemiological data suggest a general inverse risk association between them, the mechanisms of which might provide new avenues for developing treatments and prevention strategies. In addition to this...

The clinical benefit of routine PET/CT imaging in asymptomatic head and neck squamous cell cancer patients one year post-treatment

BACKGROUND: The incidence of head and neck cancer is increasing, creating a growing need for follow-up strategies. The benefit of routine PET imaging beyond six months after treatment in asymptomatic patients remains unclear. OBJECTIVE: To assess whether routine PET/CT or PET/MRI...

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and ho...

Undergraduate point-of-care ultrasound education in Northern Europe: A cross-sectional survey

Background Point-of-care ultrasound (POCUS) is increasingly recognized as a vital physician skill in acute care, yet its integration into undergraduate medical curricula in Europe remains inconsistent. This study aimed to assess the status of undergraduate POCUS education in Nort...

Influence of carbonate apatite nanoparticles incorporated into commercial dental adhesives on immediate and long‐term microtensile bond strength

Abstract This study assessed whether integrating carbonate apatite nanoparticles with a CO 3 /PO 4 molar ratio of 5 (CA5n) into commercial adhesives affected the immediate or the long‐term microtensile bond strength ( µ TBS) between composite resin and dentin. Scotchbond Multipur...

Early Language Difficulties in Association With Later Need of School Support Services in Very Preterm Children – A Longitudinal Follow‐Up Study

ABSTRACT Aim School performance requires a wide spectrum of developmental abilities including cognitive, social and behavioural skills. We aimed to study the association between developmental difficulties at 5 years and the received school support services at 8 and 11 years in ch...

Building families—Implementing balanced sexual and reproductive health

Abstract One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

Building Families—Implementing Balanced Sexual and Reproductive Health

ABSTRACT One of the main initiatives of the World Health Organization (WHO) is the promotion of Sexual and Reproductive Health (SRH). Sexuality, infertility, and contraception are three interconnected pillars of SRH, each essential for achieving global equity in family planning a...

Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes

Background/Objectives: Epidural electrical stimulation (EES) is an investigational, off-label neuromodulation strategy used adjunctively with rehabilitation in chronic spinal cord injury (SCI), but safety and longitudinal functional data specific to traumatic cervical SCI remain...

Diagnosis of urinary tract infection in the emergency department – a real infection or an alarming indication for comprehensive geriatric assessment? A retrospective follow-up study

Purpose To investigate whether urinary tract infection (UTI) diagnoses assigned in the emergency department (ED) were true UTI infections, characterize hospitalized UTI patients, and analyze the 12-month mortality and institutionalization rates. Methods A retrospective study amon...

Multi-omic profiling reveals antibody-drug conjugate targetability in ovarian cancer

Abstract Antibody-drug conjugates (ADCs) require high and homogeneous target expression for optimal efficacy, yet the spatial, temporal, and cellular heterogeneity of clinically approved ADC targets in high-grade serous ovarian cancer (HGSC) remains incompletely defined. We analy...

Regional differences and trends in treatment approaches for femoral neck fractures in Finland: A nationwide analysis

BACKGROUND AND AIMS: Femoral neck fractures represent a major health concern in aging populations due to their morbidity and mortality. Although operative treatment is the standard, regional and temporal variations in surgical approaches exist. This study evaluates nationwide tre...

Association between umbilical cord oxidative stress and early neonatal outcomes in gestational diabetes mellitus

Gestational diabetes (GDM) is frequently associated with adverse neonatal outcomes, but the underlying mechanisms linking maternal hyperglycemia to fetal harm are not fully understood. Oxidative stress has been suggested as a key pathway; however, studies simultaneously evaluatin...

Cerebral glucose utilisation during musical emotions: A multimodal functional PET/MRI study:A multimodal functional PET/MRI study

Functional magnetic resonance imaging (fMRI) studies have demonstrated music-induced activation of the blood-oxygen-level-dependent (BOLD) signal across brain networks associated with auditory perception, motor control, and emotion. However, BOLD-fMRI reflects vascular responses...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

Population pharmacokinetics of methylprednisolone in neonates and paediatric patients undergoing cardiac surgery with cardiopulmonary bypass

<title>Abstract</title> <bold>Purpose</bold> Methylprednisolone is commonly used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and procedural factors such as ci...

Joint-RPCA: domain-aware multi-omics integration for systems microbiology

Integrating multi-omics data is essential for microbiome research, as microbial communities are shaped by and respond to interdependent processes, including taxonomic composition, metabolite production and utilization, and gene expression. However, accurately capturing ecosystem-...

Longitudinal associations between sleepiness and sleep disturbances across pregnancy

OBJECTIVE: Although sleep disturbances increase during pregnancy, sleepiness does not appear to follow a similar trajectory. Given that the relationship between sleep disturbances and sleepiness during pregnancy is understudied, we examined their associations to determine whether...

Longitudinal dynamics of serum IL-33 and sST2 across age and sex in a healthy Finnish cohort before and after Tdap booster vaccinations

Background Interleukin-33 (IL-33) and soluble ST2 (sST2) are critical regulators of tissue-derived inflammation, and their dysregulation is usually implicated in various inflammatory disorders. Despite this, how these circulating proteins behave over time in healthy individuals r...