Tongji Hospital

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

sTREM2 and GFAP mediated the association of cerebrospinal fluid GLP-1R with tau pathology in alzheimer’s disease

Glucagon-like peptide-1 receptor (GLP-1R) is involved in metabolic regulation and has also been implicated in neuroprotection and the modulation of neuroinflammatory processes in the central nervous system. GLP-1R has therefore emerged as a potential therapeutic target for Alzhei...

Association between central thyroid hormone dysregulation and chronic kidney disease in type 2 diabetes: a cross-sectional study

This cross-sectional study investigated the association between central thyroid hormone resistance and chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) who have normal peripheral thyroid hormones. The study included 2,759 T2DM patients with normal ser...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

The role of mTORC2/RICTOR in immune cells and inflammatory diseases

mTORC2, defined by its core component RICTOR, is a key regulator of immune cell function and inflammation, yet its roles have long been underappreciated due to lack of specific inhibitors and in vivo tools. This review summarizes the current understanding of mTORC2-specific signa...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Donor-Type-Dependent Heterogeneity of Ischemia–Reperfusion Injury in Lung Transplantation: A Multi-Cohort Transcriptomic Interaction Analysis of DCD Versus DBD Lungs

Background: Donation after circulatory death (DCD) and donation after brain death (DBD) donor lungs are widely used in lung transplantation yet managed as equivalent with respect to ischemia–reperfusion injury (IRI), despite fundamentally different ischemic backgrounds: warm isch...

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

In this study, we demonstrate that during diabetic wound healing, interleukin-11 (IL-11) promotes the M1 polarization of macrophages, which subsequently triggers fibroblast senescence through the enhanced release of pro-inflammatory cytokines IL-1β and IL-6. Notably, Rhoifolin (R...

A succinylation-related machine learning signature reveals prognostic and immune heterogeneity in lung adenocarcinoma

Succinylation is an emerging post-translational modification involved in tumor metabolism and progression. However, the role of succinylation-related genes (SRGs) in lung adenocarcinoma (LUAD) remains poorly understood. This study aimed to systematically investigate the prognosti...

An LLM-enhanced AI agent for rapid diagnosis of acute aortic dissection in multi-center settings

Acute aortic dissection (AAD) is a high-mortality cardiovascular emergency, yet early diagnosis before computed tomography angiography (CTA) remains challenging. We developed AAD-Agent as a pre-imaging triage aid—not as a replacement for CTA—and evaluated it in a retrospective, m...

Allergic Rhinitis: From Pathology to Novel Therapeutic Approaches

Allergic rhinitis (AR) is a common chronic inflammatory disorder of the upper airway in which allergen sensitization interacts with epithelial, neural, and immune responses, as well as comorbidity and treatment context, to shape clinical expression[...]

Revealing the Shared Genetic Architecture of Metabolic Dysfunction–Associated Steatotic Liver Disease–Related Traits Through Genomic Structural Equation Modeling

Although individual traits related to metabolic dysfunction-associated steatotic liver disease (MASLD) have been investigated through large-scale genome-wide association studies (GWASs), the shared genetic susceptibility across these traits remains unclear. We therefore conducted...

Associations of PM2.5 Components, Residential Greenness, and Heatwaves with Incident Venous Thromboembolism

Abstract Aims This study aimed to explore the associations of fine particulate matter (PM2.5) components, residential greenness, and heatwaves with incident venous thromboembolism (VTE). Methods This study included 483,610 participants from the UK Biobank (mean age 56.5 years; 54...

Longitudinal profiling of urinary extracellular vesicle RNA reveals physiological variability and stable reference genes in healthy individuals

Urinary extracellular vesicles (uEVs) have emerged as promising non-invasive molecular carriers for biomarker discovery, yet the physiological variability and tissue-associated characteristics of uEV RNA cargo in healthy individuals remain poorly defined. This knowledge gap limit...

SGLT2 inhibitor ameliorates hypertension by regulating the CYP4A/20-HETE pathway in the kidney

Sodium-Glucose Transport Protein 2 inhibitors (SGLT2i), initially developed as antidiabetic agents and now established as foundational therapies for heart failure, have also shown antihypertensive effects in clinical trials involving patients with diabetes and heart failure. Howe...

POU4F3 variants are prevalent in Chinese patients with autosomal dominant non-syndromic hearing loss and concurrent tinnitus

POU4F3 (DFNA15) is an established causative gene for autosomal dominant non-syndromic hearing loss (ADNSHL); however, its mutational spectrum in the Chinese population remains incompletely characterized. This study aimed to expand the mutational spectrum of POU4F3 in the Chinese...

Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence

Background: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, resulting in an increased risk of fractures. Stem cell-derived extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strateg...

Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.

Spinal V3 interneurons are glutamatergic neurons that are distributed among the dorsal, intermediate, and ventral spinal cord. They are involved in broad neural circuit connections in the central nervous system. Functionally, they play important roles in locomotion, such as the m...

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

ABSTRACT The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and f...

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...