Tongji Hospital

Spatially defined IGF1R-STMN1 axis delineates a metastatic cell state in osteosarcoma

Abstract Metastatic osteosarcoma (OS) remains the leading cause of disease-related mortality, yet effective therapies are still lacking. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and functional assays to investigate signaling dependencies in OS meta...

Deciphering the mechanistic landscape of notch signaling in autoimmune pathogenesis

Autoimmune diseases are a group of disorders with multiple etiologies that disrupt normal immunological function, leading to the immune system mistakenly attacking the body’s own tissues. The Notch signaling pathway is a conserved pathway that is in part responsible for multiple...