Tongji Hospital

Dynamic Ovarian Lymphatic Remodeling Is Associated with Macrophage Accumulation During Follicular Development and Ovulation in Mice

The ovarian lymphatic vasculature has emerged as a potential regulator of ovarian function, yet its role in follicular development remains poorly defined. Here, we aimed to elucidate the dynamic changes in ovarian lymphatic vessels during follicular development and to determine w...

Bowstring reduction technique combined with cannulated screw fixation for Sanders type II intra-articular calcaneal fractures

Abstract Background Calcaneal fractures are the most common tarsal fractures, and displaced intra-articular fractures involving the posterior facet remain challenging for minimally invasive treatment because the achieved reduction is difficult to maintain. This study aimed to eva...

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

ABSTRACT Trastuzumab is the standard first‐line targeted therapy for human epidermal growth factor receptor 2 (HER2)‐positive gastric cancer (GC). Unfortunately, its clinical efficacy is often compromised by the development of drug resistance. The Warburg effect, a hallmark of ca...

Machine‐Learning Prediction of Tumor Comorbidity and Cancer‐Associated Mortality in Patients With Coronary Heart Disease: A 2‐Stage Modeling Study

Background Coronary heart disease (CHD) with concomitant tumors is increasingly prevalent and is associated with a higher mortality. We aimed to develop 2 predictive models to enable early identification of tumor risk in patients with CHD and mortality risk in those with CHD and...

PET imaging enables direct evaluation of ferroptosis in HCC synergistically induced by anti-PD-L1 and Olaparib

Abstract The efficacy of PET image-guided immune checkpoint inhibitor-based therapy in hepatocellular carcinoma (HCC) management is limited by the lack of direct monitoring of therapeutic response. A key challenge is the mismatch between the therapeutic pathway and the imaging ta...

Targeting REV7 confers cervical cancer cell radiosensitivity and ferroptosis by negatively regulating SFXN1

Cervical cancer is the 4th most common malignancy in women. Radiotherapy (RT) plays an essential role in cervical cancer treatments, and this study reports the role of REV7 in cervical cancer RT. Results showed that loss of REV7 contributed to increased the radiosensitivity of ce...

Chamber-Design-Associated I n Situ Formation of HepG2 Spheroids in a Perfusable Organ-on-a-Chip

Abstract Perfused spheroid platforms enable continuous mass transport, but the role of chamber architecture in in situ spheroid assembly remains insufficiently understood. Here, we developed a perfusable organ-on-a-chip platform for the in situ formation and culture of HepG2 sphe...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

The Shared Pathological Niche in Pulmonary Fibrosis: From Aberrant Epithelial Repair to ECM Remodeling

Pulmonary fibrosis is a frequent complication of abnormal tissue repair following lung injury by many causes. It can be found in various diseases and clinical conditions, such as idiopathic pulmonary fibrosis, cancer-treatment-induced lung injury, and other occupational, environm...

Prediction of prognosis and treatment effect of cervical cancer by immunogenic cell death-related genes

Background Immunogenic cell death (ICD) is a potential mechanism that mediates adaptive immune responses during anticancer therapy. However, expression patterns and clinical implications of ICD related genes in cervical squamous cell carcinoma and endocervical adenocarcinoma (CES...

Assessment of pleural effusion using intracavitary contrast-enhanced ultrasound: a pilot study

Objectives To address the limitations of current imaging modalities, the present study aimed to develop and validate a novel intracavitary contrast-enhanced ultrasound (CEUS) approach for the quantitative assessment of pleural effusion (PE) volume and differentiation of exudative...

Diagnostic Performance of Donor‐derived Cell‐free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation

BACKGROUND: Accurate differentiation of acute rejection (AR) from other causes of graft dysfunction after liver transplantation remains challenging in real-world clinical practice. Although donor-derived cell-free DNA (dd-cfDNA) has emerged as a promising non-invasive biomarker o...

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI), but therapeutics that modulate key inflammatory amplifiers remain limited. Here, we identify infiltrating macrophages as the predominant TREM1‐expressing population in TBI human and...

Regulatory T cells in liver diseases: roles and therapeutic targeting

The liver is an immune-tolerogenic organ in which coordinated interactions between resident and infiltrating immune cells maintain hepatic and systemic homeostasis. Disruption of this balance can lead to chronic inflammation, fibrogenesis, infection, and malignant transformation,...

IFNγ-dependent tumor-cell MHC-II is restrained by MAPK signaling and associated with immunotherapy responsiveness in pancreatic ductal adenocarcinoma

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by an immunosuppressive tumor microenvironment (TME) and poor prognosis. Although major histocompatibility complex class II (MHC-II) is typically expressed by professional antigen-presenting cells, its regulation a...

AI-assisted preoperative anesthesia evaluation workflow versus conventional bedside evaluation: a randomized controlled non-inferiority trial

Abstract Background Digital tools may improve the efficiency and standardization of preoperative anesthesia assessment, but evidence comparing AI-assisted workflows with conventional bedside evaluation remains limited. We compared ASA physical status classification concordance, d...

In Situ Visualization of Tumor and Drug-Induced Liver Injury with AIEgens, Polarity-Responsive, Membrane-Targeting Fluorescent Probes

Abstract Dynamic changes in the polarity of the cellular microenvironment play a pivotal role in drug-induced liver injury (DILI) and tumors, serving as a crucial biomarker for evaluating cell membrane integrity and functional status. Precise monitoring of polarity changes is ess...

Bladder Sensory Neurons as Regulators of Neuro-Immune-Urothelial Interactions: From Molecular Mechanisms to Targeted Therapy for Neurogenic Bladder and Interstitial Cystitis/Bladder Pain Syndrome

Bladder sensory neurons are essential components of lower urinary tract sensory encoding and micturition reflex control. They detect bladder filling, stretch, inflammatory mediators, and pathogen-associated stimuli, and they communicate with urothelial cells, immune cells, and st...

Multimodal Exploratory Analysis of Persistent Diabetic Macular Edema: Integrating Aqueous Humour Metabolomics, Clinical and OCT Features

ABSTRACT Purpose This exploratory study integrates aqueous humour metabolomic data with clinical and imaging features to examine candidate biomarkers and characterize multimodal patterns associated with persistent diabetic macular edema (pDME). Methods In this prospective cohort...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...