Tongji Hospital

Dietary Fatty Acids, Cardiovascular Disease, and Life Expectancy Among Adults With Adverse Mental Health‐Related Characteristics: A Cohort‐Based Target Trial Emulation Study

ABSTRACT Adverse mental health‐related characteristics contribute to decreased life expectancy, largely driven by an elevated risk of cardiovascular disease (CVD). Dietary fatty acids influence disease occurrence and progression, yet the associations of polyunsaturated fatty acid...

The potential differential significance of admission metabolic markers CHG, TyG and NHHR indices for cerebral artery dissection

At present, the diagnosis of cerebral artery dissection (CeAD) worldwide still relies on imaging findings, making rapid clinical differentiation in the early stages challenging. Our purpose is to explore the distribution characteristics of the cholesterol, high-density lipoprotei...

Perception and coping with aging among middle-aged women: a qualitative study

Middle-aged women face distinct physiological, psychological, and social challenges during the transition from adulthood to later life. However, their perceptions of aging and the strategies they employ to cope with this process remain insufficiently understood. This qualitative...

Multi-omics convergence screening reveals dual-cargo antitumor mechanisms of orally administered Houttuynia cordata-derived exosome-like nanoparticles

Plant-derived exosome-like nanoparticles (PELNs) transport multi-component molecular cargos with cross-kingdom regulatory potential and have emerged as a promising class of cancer nanomedicines. A persistent bottleneck, however, is causally linking individual cargo species to in...

The Safety and Feasibility of Laryngeal Mask Airway Management in Nonintubated Subxiphoid–Subcostal Thoracoscopic Thymectomy: Preliminary Results

Introduction While intubated general anesthesia with single-lung ventilation is regarded as mandatory for conventional thoracoscopic surgery, and various minimally invasive approaches to thymectomy have been described, nonintubated thoracoscopic thymectomy remains technically cha...

Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus

Abstract Despite undergoing exposure therapy, individuals with post-traumatic stress disorder (PTSD) frequently experience relapses when confronted with trauma reminders. This study examined the impact of extinction-restraint intervention (Ext-Res) in a PTSD-related fear relapse...

Integrative multi-omics analysis identifies SMIM24 as a favorable prognostic biomarker in clear cell renal cell carcinoma

Clear cell renal cell carcinoma (ccRCC) exhibits substantial molecular and clinical heterogeneity, contributing to variable disease progression and therapeutic outcomes. We previously identified a de-clear cell differentiation (DCCD) tumor state characterized by loss of canonical...

Nuciferine-Loaded Lipid Nanoparticle Microneedles Alleviate Intervertebral Disc Degeneration by Restoring Nucleus Pulposus Cell Homeostasis

Background/Objectives: Intervertebral disc degeneration (IDD) is a major cause of chronic low back pain and disability. Nuciferine, a natural alkaloid with mitochondrial protective activity, shows therapeutic potential for IDD. However, the avascular nature of intervertebral disc...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy is largely ineffective in most solid tumors, partially because of inadequate intratumoral trafficking. Bridging therapy, administered between leukapheresis and CAR‐T cell infusion, offers a distinct opportunity to control th...

Neuroscience in cancer care: ethical, legal, and societal challenges

Magnon C, Hondermarck H. The neural addiction of cancer. Nat Rev Cancer. 2023;23:317–34. Article CAS PubMed Google Scholar Xu M, Yu Y, Cao C. CGRP-mediated neural addiction in tumor dynamic remodeling. Trends Cancer. 2025;11:834–8. Article CAS PubMed Google Scholar Cao C. Targeti...

Arming the living drugs: nanoengineered bacteria for precision tumor theranostics

Bacteria-mediated tumor therapy exploits the innate ability of anaerobic bacteria to selectively colonize hypoxic tumor regions. However, clinical translation of this approach is hindered by three core challenges: insufficient monotherapy efficacy, the inability to non-invasively...

A case of mucopolysaccharidosis I with severely increased albuminuria and Graves’ disease, and functional analysis of previously uncharacterized variant

Abstract Background Mucopolysaccharidoses (MPS) are a group of inherited lysosomal storage disorders which results in accumulation of glycosaminoglycans throughout the body. MPS I is a subtype characterized by mutations in the α-L-iduronidase (IDUA) gene with subsequent multiorga...

Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer

Cancer metabolism is characterized by profound reprogramming, yet the mechanisms enabling rapid and precise adaptation remain incompletely understood. This review establishes post-translational modifications (PTMs) as the central processing unit of oncogenic metabolic reprogrammi...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

The Unsaturated/Saturated Fatty Acid Ratio: A Metabolic Hub and Therapeutic Vulnerability in Glioblastoma

Glioblastoma (GBM) exhibits profound metabolic reprogramming, among which the balance between unsaturated and saturated fatty acids (UFA/SFA) emerges as a critical determinant of tumor behavior and treatment response. Recent studies have shown that fatty acid metabolic reprogramm...

The landscape and plasticity of transposable element expression in an adult stem cell of high physiological and clinical significance

Abstract Transposable elements (TEs) contribute to diverse aspects of stem cell biology, particularly in germline and pluripotent stem cells, which typically exhibit more open chromatin. In human adult stem cells (ASCs), however, a comprehensive framework describing the landscape...

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...

Neutrophil percentage-to-albumin ratio is associated with in-hospital mortality in patients with acute aortic dissection: a multicenter retrospective cohort study

Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...

Layered double hydroxide-based ROS-scavenging nanozyme hydrogels re-establish osteoimmune-angiogenic coupling for osteoporotic bone repair

Abstract Background Osteoporotic bone defects (OP-BDs) present a significant clinical challenge because of a pathological microenvironment characterized by severe oxidative stress, persistent inflammation, and disrupted metabolic coupling between osteoblasts and osteoclasts. To o...