Thomas Jefferson University

Early improvements in function with atogepant as assessed by the Activity Impairment in Migraine–Diary: Post hoc analyses of three randomized, phase 3 clinical trials of atogepant for the preventive treatment of migraine

Abstract Objective Evaluate early functional improvements with the preventive migraine treatment atogepant using Activity Impairment in Migraine–Diary (AIM‐D) individual and activity limitation items, and complete improvement in AIM‐D Performance of Daily Activities (PDA) and Phy...

Predictors of Delayed and Omitted Postoperative Radiotherapy After Laryngectomy for pT4 Laryngeal Cancer

BACKGROUND: Postoperative radiotherapy (PORT) improves locoregional control and survival in high-risk head and neck cancer, and guidelines recommend initiation within 42 days of surgery. Timeliness after laryngectomy for pathologic T4 (pT4) laryngeal cancer is poorly characterize...

Why Colonoware? Exploring Functional Variations in Hand-Built Coarse Earthenwares across the Historical Upper Southeast

Abstract Colonoware, a hand-built, low-fired coarse earthenware, appears on archaeological sites occupied from the mid-seventeenth to the mid-nineteenth century throughout the southeastern United States. Although colonoware is highly variable in appearance and abundance, it is ev...

Examining the Associations of Altered Metabolism in Black Women with Endometrial Cancer

Abstract Metabolic syndrome is a modifiable risk factor in endometrial cancer patients and is predictive of disease outcomes in endometrial cancer survivors. While metabolic syndrome has been on the rise in the United States, there is also a concerning, disproportionate increase...

Operative vs non-operative management of ventral hernia: a population based study of long-term benefits and consequences

Abstract Purpose Ventral hernia (VH) management has progressed beyond simply physical repair of the defect. It now involves a strategy that purposefully restores abdominal core function and prevents future complications. This study investigates the association between ventral her...

Medetomidine as a Fentanyl Adulterant: Pharmacology, Detection, Clinical Presentation, and Management

Abstract Purpose of Review Medetomidine is a veterinary α2-adrenergic agonist that has been an adulterant of illicitly manufactured opioids since 2022. We review its pharmacology, detection, intoxication, withdrawal, and management, and assess why severe withdrawal has emerged in...

Drosophila pyruvate kinase links metabolic state with circadian output via TARANIS and PDF

Abstract The circadian clock generates ∼24-hour rhythms that anticipate daily environmental changes. Circadian clock and glucose metabolism are tightly interconnected, and both are disrupted in aging and disease. To examine how glucose hypometabolism impacts circadian rhythm, we...

Neuroimmune Phenotyping as the Next Frontier in Chronic Pain Medicine for Musculoskeletal Back Pain

Chronic low back pain encompasses heterogeneous mechanical, neuropathic, nociplastic, and myofascial presentations that may reflect distinct neuroimmune mechanisms. We synthesized evidence linking these phenotypes to measurable biological features and clinically relevant treatmen...

Prepregnancy Obesity Versus Excessive Gestational Weight Gain: A Comparative Evaluation of Adverse Outcomes

Background/Objectives: Obesity and excessive gestational weight gain (EGWG) are known risk factors for adverse outcomes in pregnancy, but the comparative risk is less well defined and increasingly relevant in an era of increasing use of weight loss medications. We aimed to determ...

Health equity and unintentional pediatric cannabis ingestion

Abstract Background Unintentional pediatric cannabis ingestion has been rising following medical and recreational legalization. In this study, we aimed to examine the epidemiology of pediatric cannabis ingestion following legalization and to assess the impact of demographic and s...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

A Randomized Controlled Trial Evaluating Negative Pressure Therapy (NPT) to Reduce Wound Complications Following Major Lower Extremity Amputation

Objective: This study hypothesizes that negative pressure therapy (NPT) reduces wound-healing complications following major amputation. Background: Major lower extremity amputation carries a high incidence of incisional complications. NPT reduces these complications in other area...

Obesity Is Associated With Earlier Mechanical Failure Following Total Ankle Arthroplasty Independent of Tibial Stem or Keel Augmentation

Background: Obesity and elevated body mass have been associated with increased rates of aseptic loosening and implant failure following total ankle arthroplasty (TAA). The purpose of this study was to investigate the role for primary stemmed or keeled tibial implants as a protect...

Rhinosinusitis in Adults Receiving Tumor Necrosis Factor Alpha Inhibitors and Anti‐CD20 Therapy: A Scoping Review

ABSTRACT Introduction Immunomodulatory therapies, including tumor necrosis factor alpha (TNF‐α) inhibitors and anti‐CD20 agents, are often used for autoimmune, inflammatory, and neoplastic disorders. While infection risk is well recognized, their association with rhinosinusitis r...

The Impact of Adverse Childhood Experiences on Youth’s Mental Health: What is the Role of Family Resilience?

Abstract Given that many adverse childhood experiences (ACEs) are family-contextual and that family processes shape youth mental health, the current study examined the role of family resilience in the relationship between ACEs and major mental health outcomes among youth aged 6–1...

Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial

Background Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of l...

Elevated Serum Renin Before Liver Transplantation Is Associated With Increased Intraoperative Vasopressor Requirements and Posttransplant Acute Kidney Injury

BACKGROUND: Derangements of the renin-angiotensin-aldosterone system may contribute to circulatory dysfunction in cirrhosis. We hypothesized that renin is elevated in patients undergoing liver transplantation (LT) and is associated with vasopressor requirements and postoperative...

Impaired effort perception, not reward sensitivity, impacts the effort-reward trade-off in Parkinson’s disease

Deciding whether and how to act depends on a trade-off between the effort required to execute a given action and the potential reward for completing it. Impairments in this effort-reward trade-off have been proposed to underlie reduced movement vigor, or bradykinesia, in Parkinso...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Mapping System Vulnerabilities in Anaesthesia Safety: A Role‐Based Inquiry in Response to Fatal Fungal Meningitis Outbreaks in Mexico

ABSTRACT Objectives Unsafe anaesthesia practices in Mexico have contributed to repeated outbreaks of fatal fungal meningitis, exposing broader health system vulnerabilities. This study aimed to analyse how structural weaknesses in perioperative care, spanning governance, workforc...