Thomas Jefferson University

A novel perioperative pathway for hip fractures in the older adult: a pre-post quality improvement study using statistical process control

Despite advances in medical care, the incidence of medical complications, especially delirium, remains high in patients with hip fracture. Although individual components of hip fracture pathways have been studied, the components together have not. At a tertiary academic medical c...

Radiation-induced meningioma and high-grade glioma following craniospinal irradiation for medulloblastoma: a case report

Background: Cranial irradiation is known to carry the risk of late intracranial toxicities, most notably the development of secondary intracranial neoplasms. Both meningiomas and gliomas can develop as radiation-induced tumors. Radiation-induced meningiomas represent the most com...

Association of Early Primary Care Follow-Up With Acute Care Use After ICU Discharge

OBJECTIVE: To determine if early primary care follow-up after pediatric intensive care unit (PICU) hospitalization is associated with reduced acute care use. METHODS: Using claims data from publicly and privately insured children, we identified a cohort of PICU hospitalizations f...

The 11th International Conference on Plasma Medicine (ICPM11) and the 10th International Workshop on Plasmas for Cancer Treatment (IWPCT10)

The 11th International Conference on Plasma Medicine (ICPM11), held jointly with the 10th International Workshop on Plasmas for Cancer Treatment (IWPCT10), took place from 31 May to 5 June 2026 in Gifu, Japan. The meeting brought together 225 scientists from 23 countries across f...

Subsequent Knee Arthroplasty Does Not Influence Patient-Reported Outcomes Following Lumbar Fusion

Study Design Retrospective Cohort Study. Objectives The impact of knee arthritis and early total knee arthroplasty (TKA) on lumbar fusion recovery remains underexplored. This study aimed to identify demographic differences between lumbar fusion patients that had subsequent TKA an...

Evaluating a Near-Peer Facilitation Model for Simulation-Based Education in Occupational Therapy

Date presented: April 23, 2026 Primary Author and Speaker: Malachy James Clancy, malachy.clancy@jefferson.edu

A Structured Framework for Translation of the ACNS Standardized Critical Care EEG Terminology Into Spanish

Purpose: The American Clinical Neurophysiology Society (ACNS) Critical Care EEG Terminology provides standardized language for describing electroencephalographic (EEG) patterns in critically ill patients but has not been formally translated into Spanish. We aimed to develop a con...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Temporal, Geographic, and Polysubstance Patterns in Orphine Analogue Detections

This cross-sectional study examines the temporal, geographic, and polysubstance patterns in orphine analogue detections.

No difference in alloimmunization of pregnant adults with sickle cell disease exposed to chronic versus on‐demand transfusions: A two‐center retrospective cohort study

Abstract Background Pregnant people with sickle cell disease (SCD) experience high morbidity and mortality, even when RBC transfusion is safe and available. There is a lack of consensus on transfusion use partly due to concern for alloimmunization. This study examined alloimmuniz...

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines i...

A 3D printed modular microscope for in-incubator time-lapse fluorescence imaging

We aim to develop a low-cost fluorescence microscope capable of obtaining time-lapse images of cell biology processes in vivo within a cell incubator setting. The commercial systems for fluorescence microscopy are expensive and require extensive setup for use in incubators. In re...

A 3D printed modular microscope for in-incubator time-lapse fluorescence imaging

We aim to develop a low-cost fluorescence microscope capable of obtaining time-lapse images of cell biology processes in vivo within a cell incubator setting. The commercial systems for fluorescence microscopy are expensive and require extensive setup for use in incubators. In re...

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frailty measures to consider...

Evaluating the Reliability, Accuracy, and Readability of ChatGPT-3.5 and GPT-4 in Providing Patient Education Related to Glenohumeral Joint Osteoarthritis.

OBJECTIVES: Chatbots have been increasingly recognized as modern tools that provide patients with reliable health-related information. This study aimed to evaluate and compare ChatGPT-3.5 and GPT-4's ability to answer glenohumeral osteoarthritis-related questions. METHODS: Fiftee...

Long-Term Follow-Up of Checkpoint Inhibitor-Associated Uveitis Treated with Fluocinolone Acetonide Intravitreal Implant in a Pediatric Patient

Purpose To describe the clinical course and 2-year follow-up of a pediatric patient treated with 0.18 mg fluocinolone acetonide intravitreal implants (Yutiq, EyePoint Pharmaceuticals) for chronic, bilateral immune checkpoint inhibitor (ICI)-associated uveitis.Methods Retrospectiv...

Artificial Intelligence and Sensing Technologies for Vascular Access in Hemodialysis: A Narrative Review

Vascular access performance determines the adequacy, safety, and cost of hemodialysis. Stenosis, thrombosis, cannulation difficulty, infection, and access-related cardiac stress remain major sources of morbidity. This narrative review examines artificial intelligence and sensing...

Development and feasibility testing of an electronic medical record intervention to improve emergency department discharge communication for patients with uncertainty: a pilot study

Abstract Background A significant proportion of patients leave the emergency department (ED) without a definitive diagnosis, leading to challenges in the post-discharge period due to diagnostic uncertainty. Building on previous work aimed at improving discharge communication, we...

Activity-based profiling of bacterial RNA-modifying enzymes reveals species-specific 5-methyluridine modification in Bacillus subtilis 23S rRNA

RNA modifications play an important role in biological processes. Mapping the diversity of RNA chemistry and studying the biological function of individual modifications remains an outstanding challenge in many organisms. In particular, RNA modifications remain poorly studied acr...

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

OBJECTIVE: SIRT6 is a nuclear-localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL-800, decreases the severity of age-associated osteoarthrit...