Thomas Jefferson University

Identification, validation, and prediction of longitudinal recovery phenotypes in degenerative cervical myelopathy: analysis of prospective cohorts and a randomised controlled trial

Background Symptom evolution in degenerative cervical myelopathy (DCM) is traditionally characterized by severity of neurological deficit. A recent expert consensus challenged this view, proposing that DCM fluctuates across neurological, functional and health-related quality of l...

Elevated Serum Renin Before Liver Transplantation Is Associated With Increased Intraoperative Vasopressor Requirements and Posttransplant Acute Kidney Injury

BACKGROUND: Derangements of the renin-angiotensin-aldosterone system may contribute to circulatory dysfunction in cirrhosis. We hypothesized that renin is elevated in patients undergoing liver transplantation (LT) and is associated with vasopressor requirements and postoperative...

Impaired effort perception, not reward sensitivity, impacts the effort-reward trade-off in Parkinson’s disease

Deciding whether and how to act depends on a trade-off between the effort required to execute a given action and the potential reward for completing it. Impairments in this effort-reward trade-off have been proposed to underlie reduced movement vigor, or bradykinesia, in Parkinso...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Mapping System Vulnerabilities in Anaesthesia Safety: A Role‐Based Inquiry in Response to Fatal Fungal Meningitis Outbreaks in Mexico

ABSTRACT Objectives Unsafe anaesthesia practices in Mexico have contributed to repeated outbreaks of fatal fungal meningitis, exposing broader health system vulnerabilities. This study aimed to analyse how structural weaknesses in perioperative care, spanning governance, workforc...

Rhythmic Scrubs: The Role of Dance in the Medical Curriculum

INTRODUCTION: Medical practice relies on fluency in non-verbal communication, particularly during physician-patient interaction and physical examination. Dance education offers a unique and valuable framework for developing internal and external communication skills. Through danc...

Gene expression and water transport in plants: A molecular introduction to plant physiology

<p>“Gene expression and water transport in plants: A molecular introduction to plant physiology” is an introductory biology activity that helps students understand the relationship between cellular and molecular properties regulating plant physiology. Th...

Impact of Medical Treatment on Nasal Discharge in Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis

Background One of the defining symptoms of chronic rhinosinusitis is nasal discharge. There are multiple treatment options, and the relative efficacy of each medication on discharge is unclear. Objective To characterize the effects of medical treatment on the various forms of nas...

Fraction-Seq: An Integrated Experimental and Computational Workflow for Determining the Localization and Abundance of Small Non-Coding RNAs in Subcellular Compartments

Small non-coding RNAs (sncRNAs) have garnered considerable attention in recent years, following accumulating evidence of their critical roles in many cellular processes. Among sncRNAs, microRNAs (miRNAs) and their isoforms (isomiRs), tRNA-derived fragments (tRFs), rRNA-derived fr...

Arthroscopic Bioabsorbable Fixation Achieves Favorable Outcomes for Unstable Knee Osteochondritis Dissecans Lesions Compared With Open Fixation and Metal Implants: A Systematic Review

PURPOSE: To systematically review studies evaluating the outcomes, complication rates, and revision rates among open, arthroscopic, and combined internal fixation techniques for unstable osteochondritis dissecans lesions of the knee, with specific attention to implant type and sk...