The University of Texas MD Anderson Cancer Center

The Global Immune–Nutrition–Inflammation Index (GINI) as a Candidate Prognostic Marker in Patients with Cutaneous Squamous Cell Carcinoma Treated with Cemiplimab

Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent malignancy. While Cemiplimab has transformed the treatment landscape across various disease stages, reliable pretreatment biomarkers for risk stratification remain lacking.. The Global Immune–Nu...

Patient characteristics and outcomes of colorectal cancer at a cancer hospital in Rwanda: results from a retrospective cohort

Colorectal cancer (CRC) is a significant contributor to cancer mortality in sub-Saharan Africa, yet it remains understudied. This study describes care gaps and survival outcomes of CRC in Rwanda. This was a retrospective observational cohort study. We included patients treated at...

Perioperative peripheral nerve blocks for elective below-knee amputations and phantom limb syndrome: an exploratory multicenter retrospective cohort study

Background Phantom limb syndrome (PLS) is a common complication following below-knee amputations (BKA) causing painful and/or nonpainful sensations in the absent limb. Peripheral nerve blocks (PNBs) are used for perioperative analgesia, but their association with PLS risk remains...

FLT3-directed therapy in acute myeloid leukemia: lessons from the final analysis of LACEWING

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Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease

The blood-brain barrier (BBB) is a highly specialized interface between the central nervous system and the peripheral circulation, crucial for maintaining neuronal homeostasis and protecting the brain parenchyma from potentially harmful blood-borne substances. This review examine...

Psilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation

Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling, often irreversible toxicity that affects millions of patients, limits life-saving cancer therapy, and lacks proven treatment. In this work, we show that as little as two doses of psilocybin before chemotherapy dura...

A phase II multi-institutional single arm trial evaluating TG4010 vaccine plus nivolumab in non-small cell lung cancer

Immune checkpoint inhibitors (ICIs) have transformed non-small cell lung cancer (NSCLC) therapy, but only 25% of patients have durable responses. TG4010, a mucin 1 (MUC1) vaccine, has demonstrated activity in NSCLC. We conducted a multi-institutional study to determine the safety...

Alcohol Use Severity Among Hispanic Emerging Adult College Students: Examining Acculturation Stress, Self-Esteem, and Resilience in a Stress and Coping Framework

Research on acculturation stress and its effects on alcohol-related outcomes among Hispanics has been the subject of many studies. However, these studies are limited because they generally use a single measure of acculturation stress to account for this complex construct, and mos...

Epidemiology and Species Distribution of Candida Bloodstream Infections in a Comprehensive Cancer Center, 2008–2023

Abstract Introduction Candida bloodstream infections remain a significant complication of malignancies and their therapies. Aim To investigate the epidemiology of Candida species causing bloodstream infections in patients with malignancies. Methods We retrospectively reviewed blo...

Functionally active lymphoid aggregates correlate with improved prognosis in brain metastases

Abstract B cells and their cellular neighborhoods, i.e., lymphoid aggregates (LAs) and tertiary lymphoid structures (TLS), have not been extensively studied in melanoma brain metastases (BM) or lung adenocarcinoma (LUAD) BM, despite their prognostic value and role in immunotherap...

Elevated translocator protein in skull bone marrow is linked to human chronic pain

The skull bone marrow (SBM) is emerging as a critical hub for neuroimmune signaling, yet its role in chronic pain is unknown. Using integrated positron emission tomography/magnetic resonance imaging, here, we show that the levels of 18-kilodalton translocator protein (TSPO), a pu...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Treatment of Congenital Cytomegalovirus Beyond the Neonatal Period: A Single‐Arm Meta‐Analysis

ABSTRACT Objective To evaluate hearing outcomes in postneonatal treatment of congenital cytomegalovirus (cCMV) infection and assess the effect of treatment initiated after the first month of life. Data Sources PubMed, Embase, Web of Science, and Cochrane Library were systematical...

Identifying expanding TCR clonotypes with a longitudinal Bayesian mixture model and their associations with cancer patient prognosis, metastasis-directed therapy, and VJ gene enrichment

MOTIVATION: Examination of T cell receptor (TCR) clonality has become a way of understanding immunologic response to cancer and its interventions in recent years. An aspect of these analyses is determining which receptors expand or contract statistically significantly as a functi...

The Impact of Intrathecal Hydrophilic Opioids on Postoperative Pain, Opioid Consumption and Adverse Events for Abdominal Surgery: A Systematic Review and Meta-analysis

Abstract Purpose of Review Intrathecal morphine (ITM) is a promising analgesic option for major abdominal surgery, but its clinical efficacy, potential adverse events and optimal dosing require further investigation. Methods We searched MEDLINE, Embase, and Cochrane Central Regis...

Summary of Research: Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma

This is a summary of the original research article “Brentuximab Vedotin and Nivolumab in Combination with Chemotherapy for Nonbulky, Early-Stage Classical Hodgkin Lymphoma.” The phase 2 SGN35-027 study (NCT03646123) is a multiple-part clinical trial of brentuximab vedotin (BV), w...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...

The emerging roles of non-coding RNAs in cancer

Abstract Non-coding RNAs (ncRNAs) regulate gene expression through transcriptional, post-transcriptional, and epigenetic mechanisms, shaping hallmarks of cancer, including metastasis, therapy resistance, and relapse. Carcinogenesis arises when aberrant ncRNA networks initiate mal...

Spinal laser interstitial thermal therapy for treatment of chordoma: single-center experience and literature review

PURPOSE: Chordomas are rare, locally aggressive tumors for which effective salvage options are limited once maximal surgical and radiation therapy have been exhausted. Laser interstitial thermal therapy (LITT) is a minimally invasive, MRI-guided ablative technique established for...

Cheminformatic identification of small molecules targeting acute myeloid leukemia

Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis and high relapse rates when treated with cytotoxic chemotherapeutics. Previously, we identified a family of small molecules that modulate mitochondrial function, referred to as PS1...