The University of Texas MD Anderson Cancer Center

Real‐world outcomes of nivolumab‐ AVD and brentuximab vedotin‐ AVD in paediatric and adult advanced‐stage Hodgkin lymphoma

Summary Brentuximab vedotin (BV)‐doxorubicin, vinblastine and dacarbazine (AVD) and nivolumab (N)‐AVD have transformed the frontline treatment of advanced‐stage Hodgkin lymphoma (HL), yet real‐world comparative data remain limited. In this multicentre retrospective study across 1...

Microfluidics-Enhanced 3D DNA-Based Points Accumulation for Imaging in Nanoscale Topography

Abstract Single-molecule localization microscopy (SMLM) enables the examination of biological samples at the nanoscale. DNA-based points accumulation for imaging in nanoscale topography (DNA-PAINT) is a flexible SMLM-based approach with a broad capability for multiplexing. Howeve...

Loss of human SMC5/6 induces spindle multipolarity and genome stress exacerbated by BLM helicase deficiency

Abstract Mutations of the human SMC5/6 genome maintenance complex can lead to several genome instability syndromes and are associated with tumorigenesis. However, the molecular consequences of SMC5/6 deficiencies in human cells are only partly known, preventing a better understan...

Surgical Management of Lacrimal Gland Tumors

Epithelial lacrimal gland tumors are rare but important to diagnose early. The initial surgical decision to do an incisional biopsy versus gross total resection depends largely on the radiologic characteristics of the lacrimal gland mass. Until recently, orbital exenteration was...

Hv1 deficiency disrupts splenic antibacterial defense and immune homeostasis 18 months after traumatic brain injury in male mice

Traumatic brain injury (TBI) is increasingly recognized as a chronic condition with lasting systemic consequences. Beyond persistent neuroinflammation, long-term TBI disrupts peripheral immune homeostasis, increasing susceptibility to infection and organ dysfunction, particularly...

Urine Drug Testing at an Ambulatory Pain Clinic in Patients Receiving Opioids for Cancer Pain

Importance: Urine drug test (UDT) can help screen and monitor aberrant controlled substance use among patients requiring opioid therapy for cancer pain. However, data on UDT utilization in patients with cancer pain remains limited. Objective: To determine the rate of UDT ordering...

MR‐Linac Successfully Guided the Treatment of a Free‐Moving Mesenteric Mass

Abstract A patient presenting with stage I follicular lymphoma was dispositioned for a definitive and curative radiation treatment. The tumor had significant daily movement, as much as 3.83, 3.26 and 12.42 cm in the anterior‐posterior, superior‐inferior and left‐right direction r...

Computed Tomography‐ and Photoacoustic Imaging‐Active Bioresorbable Electrospun Bismuth Nanoparticle‐Infused Small‐Diameter Vascular Grafts

ABSTRACT Bioresorbable small‐diameter vascular grafts lack inherent radiopacity, hindering noninvasive longitudinal monitoring of device integrity and complications. Hence, this study introduces a bismuth nanoparticle (BiNP)‐infused electrospun polycaprolactone (PCL) small‐diamet...

Advances in the management of pediatric morphea: a narrative review

Pediatric morphea, also known as localized scleroderma, is a rare autoimmune condition characterized by skin fibrosis and, in severe cases, deeper tissue involvement. This review highlights the epidemiology, clinical presentation, and diagnostic challenges associated with pediatr...

Emerging therapeutic strategies and clinical development of investigational agents for conventional chondrosarcoma

Introduction Conventional chondrosarcoma (cCS) is a malignant bone tumor withintrinsic resistance to cytotoxic therapy. Advances in genomic profiling have revealed recurrent alterations that are redefining the therapeutic landscape for these tumors.Areas covered Literature search...

Dual Functions of B7-H3-MAPK Signaling Orchestrate Tumor Immunosuppression via Regulating the Plasticity of Myeloid-derived Suppressor Cells and Fibroblasts

B7-H3/CD276 is an emerging immunotherapy target in cancers. However, limited knowledge of B7-H3 signaling and its role in modulating the tumor microenvironment hinders the clinical application of B7-H3-targeting therapy. Here, we report that B7-H3 plays dual roles in regulating m...

Program-Level Neoadjuvant Chemotherapy Use and 10-Year Survival in Advanced Ovarian Cancer

This comparative effectiveness research examines the association between neoadjuvant chemotherapy adoption by US cancer programs and 10-year survival among patients with advanced ovarian cancer.

Influence of Variant of Uncertain Significance (VUS) Genetic Testing Results on Mastectomy Choice in Lumpectomy-Eligible Patients

Abstract Purpose Our objective was to evaluate whether having a germline variant of uncertain significance (VUS) influenced the decision to undergo bilateral mastectomy (BLMast) among lumpectomy-eligible patients with unilateral breast cancer. Methods This retrospective cohort st...

Reappraisal of Cisplatin vs Carboplatin Treatment for Solid Tumors

Importance Cisplatin and carboplatin are central pillars of chemotherapy in solid tumor oncology, but their comparative efficacy and tolerability remain variably defined in the literature across tumor types and settings. Objective To quantify and grade the certainty of evidence c...

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Impact of post‐chemotherapy classification on outcomes in stage III and IV unilateral favorable histology Wilms tumor: Pooled data from Children’s Oncology Group AREN0532, AREN0533, and AREN03B2 studies

Abstract Background Improvements in therapy for patients with favorable histology Wilms tumor (FHWT) have relied on refinement of risk stratification for therapeutic assignment through identification of favorable and unfavorable prognostic factors. Although well established in In...

Pancreatic Cancer Screening and Early Detection: Where Are We Now?

Screening for pancreatic cancer with imaging techniques in high-risk individuals—including patients with a genetic predisposition, a family history, or precursor lesions—is critical for improving early detection and survival outcomes, and multimodal strategies that integrate AI-e...

Multilevel factors associated with nonresponse to patient-reported outcome measures in routine radiation oncology care

Nonresponse to routinely collected patient-reported outcome measures (PROMs) threatens the representativeness of aggregated data. We characterized patient-, provider-, and clinic-level factors associated with PROMIS Global-10 nonresponse in routine radiation oncology care. In thi...

Clinical evaluation of AI-assisted quantitative marrow fibrosis assessment using Continuous Indexing of Fibrosis (CIF)

Abstract Assessment of fibrosis is central to the evaluation of diagnostic bone marrow trephine (BMT) biopsies. However, manual fibrosis grading is subjective and only semi-quantitative. We evaluated the clinical utility of a previously developed AI-based quantitative fibrosis as...