Institution
The University of Texas MD Anderson Cancer Center
Recent research
- BiologyOpen access
A compendium of next-generation patient-derived models for diverse cancers
Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...
- Biology
BACKGROUND: Acute respiratory distress syndrome (ARDS) causes significant morbidity and mortality during viral pneumonia, including SARS-CoV-2 infections. Nevertheless, most patients with SARS-CoV-2 infections recover seamlessly without developing ARDS, suggesting the existence o...
- Health & Medicine
Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...
- AI & Computing
BAP: Bayesian Biomarker-Assisted Platform Design for Dose Ranging in Multi-Agent Multi-Dose Trials
Assessing the long-term benefits of new treatments can be expensive and time-consuming, particularly in disease areas with unmet medical needs. While platform trials enable the evaluation of multiple interventions simultaneously, they currently cannot assess studies involving mul...
- BiologyOpen access
BACKGROUND: Mastectomy rates in women with breast cancer are higher in younger women than in older women. The impact of this more extensive surgery on overall survival (OS) and locoregional recurrence in younger women is unknown, especially after neoadjuvant systemic therapy (NST...
- Health & Medicine
Top 10 Tips Palliative Care Clinicians Should Know About Preventing Burnout
Health care worker burnout is a potential job hazard. Palliative care clinicians (PCCs) are especially vulnerable due to the intense emotional and challenging demands of the work. Creating environments for PCCs to thrive is the responsibility of the organization, however, PCCs ha...
- Health & MedicineOpen access
Abstract Background Trophoblast cell surface antigen 2 (Trop-2) is a targetable transmembrane glycoprotein commonly overexpressed in breast cancer (BC). This study combines a systematic review and meta-analysis with a retrospective analysis of an independent early BC patient coho...