The University of Texas Health Science Center at Houston

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

A distinct gastrointestinal symptom profile characterizes clinically relevant fatigue in systemic sclerosis

OBJECTIVE: To identify the specific gastrointestinal (GI) symptoms associated with clinically relevant fatigue in systemic sclerosis (SSc), beyond the established association between overall GI involvement and fatigue. METHODS: We conducted a cross-sectional study including conse...

Mild behavioral impairment and risk of incident dementia: A systematic review and meta-analysis

BackgroundLate-life emergence of persistent behavioral changes has been recognized as a clinically meaningful sign of neurodegeneration. These neuropsychiatric symptoms, operationalized as mild behavioral impairment (MBI), represent a unique pathway through which early dementia s...

Firearm Thefts from Vehicles in the United States: Results from a National Survey of Firearm Owners

Abstract This study examines the prevalence, characteristics, and behavioral responses associated with firearm thefts from vehicles in the United States. Data are from a national survey of firearm owners conducted by YouGov in February–March 2026 ( n = 1,976). Overall, 2.7% of re...

Delusional infestation in Parkinson disease: a case report of medication-induced psychosis

Delusional infestation (DI) is an uncommon manifestation of psychosis in Parkinson disease (PD), and is often associated with dopaminergic therapy. We describe a 66-year-old woman with PD who developed visual and tactile delusions of a parasitic infestation while receiving dopami...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Sexual health and relationship training needs of the substance use workforce: findings from a cross-sectional study

People receiving treatment for substance use disorders and those in long-term recovery who have a history of sex and drug-linked behavior are at greater risk of substance use recurrence than those without a history of problematic sexualized drug use. Yet, recovery support service...

Lung cancer risk prediction using interpretable ensemble models on lifestyle and clinical data

Lung cancer remains one of the leading causes of cancer-related mortality worldwide, where early detection and reliable risk assessment are critical for improving outcomes. This study develops and evaluates a range of ensemble learning models for lung cancer prediction using life...

Alcohol Use Severity Among Hispanic Emerging Adult College Students: Examining Acculturation Stress, Self-Esteem, and Resilience in a Stress and Coping Framework

Research on acculturation stress and its effects on alcohol-related outcomes among Hispanics has been the subject of many studies. However, these studies are limited because they generally use a single measure of acculturation stress to account for this complex construct, and mos...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

sGC oxidation impairs NO-dependent ophthalmic artery vascular reactivity and alters long-term memory performance in mice

Nitric oxide (NO)-dependent activation of soluble guanylyl cyclase (sGC) is essential for maintaining cerebrovascular function and cognitive processes. However, sGC is susceptible to oxidative inactivation under vascular and neurodegenerative stress. This study investigated the i...

PIWIL4 regulates gene expression and piRNA levels in RSV-infected airway epithelial cells

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections with significant morbidity and mortality in young children, the elderly and immunocompromised hosts. Despite its clinical burden, no effective RSV vaccine or therapy exists for infant...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Polarity-aware knowledge graph reveals diet–microbiome–health mechanisms with relevance to muscle, immune and metabolic aging

Diet profoundly influences gut microbial composition and metabolism, yet mechanistic pathways linking dietary exposures to human health remain fragmented across the literature. To systematically organize and integrate this evidence, we constructed an evidence-weighted Diet-Microb...

The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson’s disease and all-cause mortality risks and transitions: The UK Biobank study

We investigated the joint associations of circulating neurodegeneration markers—neurofilament light (NfL) and glial fibrillary acidic protein (GFAP)—ambient air pollution, and plasma metabolomic profiles with transitions from a healthy state to dementia, Parkinson’s disease (PD),...

Fire-Smoke InducedProtein Alterations in Firefighters'Body Fluids Identify Prognostic Pan-cancer Biomarkers

Abstract Firefighters are routinely exposed to complex mixtures of toxicants during fire suppression, and growing evidence links these exposures to elevated cancer risk. Proteomic profiling provides a sensitive means to detect early molecular alterations associated with such occu...

A Wastewater-basedModeling Framework for InferringNorovirus Transmission Dynamics

Abstract Norovirus is a leading cause of gastroenteritis globally, yet its true infection burden in the community remains poorly understood because of widespread asymptomatic transmission and underreporting. Wastewater-based surveillance is a promising approach for tracking infec...

National Trends, Postoperative Antibiotic Utilization, and Complications Following Operative Management of Mandibular Condylar Fractures: A TriNetX Database Review

BACKGROUND: Debate persists regarding the management of condylar fractures. While systematic reviews and retrospective studies have examined clinical outcomes, national complication profiles, and postoperative antibiotic utilization remain incompletely characterized. METHODS: The...

Necessity and plurality of neural dynamics under ROSE

I am grateful to the authors of the commentary articles for identifying productive points of pressure for any neurocomputational account of syntax: whether semantic interpretation can proceed without a full syntactic derivation; how dynamical motifs are selected and coordinated;...