The University of Melbourne

IHFD: an improved heartbeat-based failure detector of $$\Diamond \,P$$ class for partially synchronous hierarchical distributed systems

Fundamentally, failure detectors are important for failure detection in distributed systems, particularly in partially synchronous environments, where message delays and process failures are unavoidable. This paper proposed an Improved Heartbeat-based Failure Detector (IHFD) for...

Synthesis and Antiparasitic Activities of New Organometallic Derivatives of the Benzimidazole Anthelmintic Drugs

About 50 years after their development, the benzimidazole anthelmintic drugs still occupy a key role in the treatment of parasitic diseases. Like other anti-infective drugs, their extensive use has led to resistance development and now requires new solutions to treat these diseas...

Defining and Measuring Developmental Regression During Childhood: A Scoping Review

ABSTRACT Developmental regression during childhood is inconsistently defined and measured, resulting in delayed diagnostic discovery and intervention. This study aimed to examine published definitions and measures for developmental regression. A comprehensive search strategy was...

Associations between metabolic dysfunction–associated steatotic liver disease and physical and mental health–related quality of life in older adults

Metabolic dysfunction–associated steatotic liver disease (MASLD) is a common, often overlooked liver condition. Its impact on quality-of-life in older adults is not well understood. We examined the association between MASLD and physical and mental quality of life in a well-charac...

Charge‐Redistribution‐Driven Dual‐Single‐Atom Catalysts on MXene for Hydrogen Evolution

ABSTRACT The hydrogen evolution reaction (HER) exhibits pH‐ and electrolyte‐dependent pathways, imposing intrinsic challenges on the development of catalysts that operate efficiently across wide pH conditions and in seawater electrolysis. Here, we report a dual‐single‐atom cataly...

Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment

Clinical failure of antibiotic therapy can occur in the absence of measurable resistance, yet the biological basis of this discordance remains poorly understood. Here, we identify a transient survival phenotype that limits dalbavancin efficacy and may contribute to treatment fail...

Historical Anti-Fascism and Right-Wing Voting in Italy

We study how anti-fascist opposition during Mussolini’s dictatorship affects post-war support for right-wing parties in Italy. We construct a measure of anti-fascism from the universe of recorded opponents, and use newly digitized historical data to resolve simultaneity between t...

Evolution of spectra and convection velocities of a turbulent boundary layer over an axisymmetric body

Time-resolved particle image velocimetry and hot-wire anemometry are employed to examine the spectral characteristics and frequency-dependent convection velocities of a turbulent boundary layer developing over an axisymmetric body of revolution subjected to varying pressure gradi...

Understanding barriers and facilitators to breast cancer screening: insights from South Asian women and general practitioners in Victoria, Australia

BACKGROUND: South Asian women, like many other culturally and linguistically diverse populations in Australia, remain under-represented in breast cancer screening, perpetuating inequities in early detection and treatment. To explore perspectives of South Asian women and general p...

DynamicTechno-Economic and Environmental Analysisof Biofuel, Powerfuel, and Hybrid Sustainable Aviation Fuel Pathways

Abstract Decarbonising aviation demands scalable, cost-effective sustainable aviation fuel (SAF) solutions to meet 2050 net-zero targets. This study aims to evaluate the comparative performance and longer-term implications of key mature and emerging SAF pathways under real world...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

Surveys of Hintang standing stone sites and excavations at Site 7A, Houaphanh, Lao PDR

Archaeological research conducted by a Lao-Australian team at the Hintang (standing stone) sites in Houaphanh Province, Laos, has permitted the geolocation of standing stone groups and the recovery of excavated archaeological remains from one site, including earthenware ceramics,...

AI failures in the eyes of the downstream developer: a first look at concerns, practices, and challenges

Abstract With the advancement of AI models, more software systems are adopting AI as a component to facilitate automation. Pre-trained models (PTMs) have become a cornerstone of AI-based software, allowing for rapid integration and development with lower training cost. However, t...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...

An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation

CDC42 is an evolutionarily conserved guanosine triphosphatase (GTPase) regulating critical cellular and immune processes. Variants in CDC42 therefore cause a spectrum of developmental phenotypes, including hematological and immunological symptoms. Here, we identify a previously u...

Rethinking Muscle Wasting in Critical Illness: A Systematic Review and Meta-Analysis of Myofiber Size and Protein Turnover

OBJECTIVES: To identify biological findings underlying skeletal muscle dysfunction in adults with critical illness and meta-analyze myofiber cross-sectional area and protein turnover variables. DATA SOURCES: Six databases were electronically searched from inception to January 202...

International healthcare professionals’ competence in caring for LGBTQ+ children and young people: a combined qualitative and quantitative approach

Objective To evaluate healthcare professionals’ attitudes, knowledge and clinical preparedness in caring for lesbian, gay, bisexual, transgender, queer/questioning; the + denoting inclusion of all identities (LGBTQ+) children and young people across international healthcare setti...

Implementing evidence in residential aged care facilities: a longitudinal multi-method evaluation of knowledge broker evolution

Background Knowledge brokers act as intermediaries to bridge evidence-to-practice gaps. Limited evidence describes how the knowledge broker role in health settings evolves over time. This study aimed to (a) examine the evolution of knowledge broker activities over a 12-month impl...

Assembly of Bioactive Superstructures via Metal–Phenolic Complexation for Blood Purification

ABSTRACT Hyperbilirubinemia, which stems from bilirubin accumulation caused by liver failure, can lead to jaundice, multi‐organ damage, and mortality. Hemoperfusion is the most effective detoxification approach, and its efficacy critically depends on the adsorbent system. However...

Modelling the effects of travel time use on mode choice and the value of travel time savings: tackling self-selection and endogeneity bias

Preferences for travel-based activities may lead individuals to choose travel modes that best accommodate activity needs. In theory, “passengerised” modes, such as public transport and automated vehicles (AVs), could become the preferred travel options, as they enable a wider ran...