The Seventh Affiliated Hospital of Sun Yat-sen University

Discovery ofa Potent APOBEC3B Inhibitor to AugmentAntitumor Immunity and Reduce Inflammatory Toxicity

Abstract APOBEC3B (A3B), a key driver of cancer mutagenesis, has emerged as a promising therapeutic target to be ablated to enhance antitumor immunity while reducing intestinal inflammation. Starting from SMC247 (3, 5-diiodotyrosine), a kelp-derived natural product, we identified...

Interaction-AwareGraph Learning for State-of-HealthEstimation of Sodium-Ion Batteries

Abstract Accurate state-of-health (SOH) estimation is critical to the reliable operation and large-scale deployment of sodium-ion batteries (SIBs). However, the complex and nonstationary degradation behavior of SIBs under different charging protocols pose a major challenge to ach...

Discovery of a peripheral Myh11-expressing nucleus pulposus cell population demontrating therapeutic potential for disc degeneration

Continual turnover of nucleus pulposus (NP) cellularity is critical for maintaining intervertebral disc (IVD) homeostasis; however, the presence and identity of potential progenitor cells within the NP remain unclear. This study identifies NP cells expressing myosin heavy chain 1...

Matrix Stiffness-Encoded Mechanical Memory Maintains Proliferative Dominance in Metastatic Tumors

Primary and metastatic lesions share similar biological properties despite existing in different microenvironments. A better understanding of the mechanisms underlying the maintenance of phenotypic homogeneity in heterogeneous microenvironments could help identify strategies for...