The Ohio State University Wexner Medical Center

Adenosine Deaminase-Mediated Purine Dysfunction Leads to DNA Repair Inhibition and Senescence in Sporadic Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by the death of motor neurons leading to paralysis and death generally 3–5 years post-symptom onset. ALS is a cell- and non-cell-autonomous disease, with glia such as astrocytes influencing disease p...

Continuous Glucose Monitoring Hypoglycemia Alarms in Critical Care: Clinical Utility and Workflow Integration

Background: Continuous glucose monitoring (CGM) has been associated with reductions in inpatient hypoglycemia; however, little is known about the performance and integration of CGM hypoglycemia alerts and alarms in the intensive care unit (ICU). We evaluated hypoglycemia signal f...

Sex differences in social cognition: Insights from a sample enriched for social dysfunction

Research suggests there are sex differences in social cognitive abilities, with females typically performing better on tasks involving emotion recognition and mental state attribution. However, many prior studies have demonstrated limited replicability, perhaps due to differences...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...

Reassessing Effect of Length of Antibiotic Therapy in Post-Surgical Endocarditis (RELAPSE): is extended antibiotic therapy still necessary after surgical intervention?

Infective endocarditis (IE) requiring surgical intervention is a complex condition in which the optimal postoperative antibiotic duration remains uncertain. While current guidelines suggest that antibiotic duration does not need to be extended after cardiac intervention when intr...

The School-to-Guardian Pipeline: Understanding the Medical and Social Implications for Individuals with Significant Disabilities

Abstract Purpose of Review As children move from being a minor to 18 and over as adults, the decision-making power shifts from the parent to the now adult child. That is unless legal guardianship is sought. One of the first encounters parents begin to really process the ramificat...

TLR8 Stimulation Leads to Microenvironment Activation and Enhanced Antibody-Dependent Cellular Responses in CLL

Toll-like receptors (TLRs) are crucial for eliciting immune responses against pathogens such as bacteria and viruses. TLR activation has also been studied for its potential to drive antitumor activity in immune cells. TLR8 is an intracellular receptor that recognizes single-stran...

Efficacy of student developed and led high value care education in preclinical medical students

The Institute of Medicine estimates that, on average, about one third of all healthcare waste is attributed to unnecessary services. High value care (HVC) is a proposed solution to this problem but is currently underrepresented in preclinical undergraduate medical education (UME)...

Preoperative Clinics: Do We Still Need Them? Reframing the Preoperative Period as a Treatment Window

Abstract Purpose of Review This review examines whether the traditional preoperative assessment clinic, designed primarily to reduce perioperative complications, improve patient safety, and prevent day-of-surgery cancellations, remains the appropriate model for perioperative care...

Optimal Strain Combinations for Prognostic Prediction in Pulmonary Arterial Hypertension

BACKGROUND: Strain parameters are sensitive indicators of myocardial performance, but the optimal combination for prognostic prediction in pulmonary arterial hypertension remains unclear. METHODS: Patients diagnosed with pulmonary arterial hypertension between June 2013 and June...

Caring for Young Adults with Breast Cancer: Providers’ Perspectives on Burnout in a Complex Care Landscape

PURPOSE: While challenges faced by young adults (YAs) aged 18-39 years with breast cancer are well-documented, health care providers' experiences caring for YAs are underinvestigated. Given high burnout rates among oncologists, this study explores providers' perspectives about ho...

Vitamins and Human Health: 3rd Edition Editorial

Vitamins are essential micronutrients that regulate numerous physiological responses critical to human health: cellular metabolism, immune function, endocrine signaling, tissue repair, musculoskeletal performance, and more [...]

Cardiac Contractility Modulation: Implications in Heart Failure, a Current Review.

Cardiac contractility modulation (CCM) is a novel therapeutic approach for heart failure patients, which utilizes nonexcitatory electrical myocardial stimulation in the absolute refractory period of the cardiac cycle. This stimulation has been shown to increase contractility, lea...

Resection Margin Status, Recurrence Pattern, and Salvageability After Resection for Colorectal Liver Metastases

Abstract Background The prognostic significance of margin status after colorectal liver metastases (CRLM) resection remains debated in the era of effective systemic therapy. This study examined the prognostic meaning of microscopically positive (R1) margins, focusing on recurrenc...

Postoperative blood glucose levels: A predictor of poor survival in resected pancreatic cancer

Abstract Background: Although pancreatic resection influences glucose metabolism, the clinical impact of postoperative fasting blood glucose (FBG) on survival outcomes in patients undergoing curative-intent resection for pancreatic cancer remains unreported. Methods: Data from pa...

L-ICON3 Suppresses Endometriosis in a Murine Model

Endometriosis is a chronic, systemic gynecological disorder that affects 190 million women worldwide. Current treatments consist of hormonal suppression and surgical excision; however, both have considerable side effects and a high risk of recurrence. Here, we report a systemic t...

The gut microbiome in chemotherapy-induced fatigue: Exploring clinical associations and modulation via fecal microbiota transplantation in female mice

Background Fatigue is a common and debilitating side effect of chemotherapy, negatively affecting treatment adherence and survival. Chemotherapy alters gut microbiome composition, and accumulating evidence suggests that gut microbes contribute to chemotherapy-induced fatigue. Bec...

We don’t know if we don’t ask”: Reply to Tham, et al

Jennica N Johns, MD, Kathleen O Lindell, PhD, RN, ATSF, FAAN; We don’t know if we don’t ask”: Reply to Tham, et al, Annals of the American Thoracic Society

Reasonable Exceptions From Unreasonable Policies: Requiring Treatment Agreements for Long‐Term Opioid Therapy and Exemptions for Cancer and Terminal Illness

Since drug overdose deaths began increasing in the United States, policy makers and the medical community have developed tools to try to address the crisis. Opioid Treatment Agreements (OTAs) are one such tool which purportedly seek to promote shared decision-making and informed...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...