The First Affiliated Hospital, Sun Yat-sen University

Baseline airway dysfunction and small-airway abnormality burden are longitudinally associated with adverse ultradistal radial bone density outcomes in a 5-year cohort

Impaired pulmonary function has been linked to lower bone mineral density and higher fracture risk, but longitudinal evidence on airway dysfunction and subsequent peripheral bone-density outcomes remains limited. We investigated whether baseline airway dysfunction, FEV1/FVC, and...

Efficacy and safety of upadacitinib for Crohn’s disease in patients in East Asia: a post hoc analysis of randomized phase 3 studies

Abstract Background Upadacitinib is an oral Janus kinase inhibitor approved for the treatment of moderate-to-severe Crohn’s disease (CD). This post hoc analysis reports the efficacy and safety of upadacitinib for CD in patients in East Asia enrolled in the phase 3 clinical trials...

In Vitro Litholytic Effects of Three Chinese Herbal Extracts on Mixed-Type Urinary Calculi.

litholytic effects on this mixed-type calculus subtype，suggesting their potential as therapeutic agents for clinical management of urolithiasis.

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

Patients’ perceptions of male and female nursing interns in Guangdong and Guangxi, Southern China

Nursing remains female-dominated globally, with gender stereotypes hindering workforce diversity. Male nurses account for 2% to 5% of China’s nursing workforce, and Guangdong/Guangxi lack studies on patients’ perceptions of male nursing interns. This study aims to explore relatio...

Targeting DNA damage signaling in atherosclerosis: molecular mechanisms and therapeutic opportunities

Atherosclerosis is a lipid-driven, chronic inflammatory disease of large and medium-sized arteries that underlies major cardiovascular events and remains a leading cause of mortality and morbidity worldwide. It is characterized by the progressive formation of lipid-rich plaques w...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Neutrophil Extracellular Trap-Derived DNA Activates the ITGB1/FAK Pathway to Promote Lung Adenocarcinoma Metastasis

Abstract Neutrophil extracellular traps (NETs) have recently emerged as key modulators of cancer progression and metastasis. However, a more comprehensive understanding of the underlying mechanisms could help identify effective strategies to prevent and treat NET-mediated metasta...

MitoGPS: A Mitochondrial DNA G‐Quadruplex‐Targeting Strategy for Tumor‐Preferential Type I Photodynamic Therapy

ABSTRACT Photodynamic therapy (PDT) is a clinically promising, minimally invasive cancer treatment offering precise spatiotemporal control. However, achieving preferential tumor accumulation remains a critical challenge, which limits therapeutic efficacy and induces off‐target to...

Benzo[a]pyrene-induced METTL3 overexpression accelerates renal cell carcinoma progression via m6A modification of LTB4R mRNA and enhanced Treg infiltration

Benzo[ a ]pyrene (BaP) is a widespread environmental pollutant and a representative polycyclic aromatic hydrocarbon with well-established carcinogenic properties. However, the molecular mechanisms through which BaP promotes renal cell carcinoma (RCC) progression, particularly tho...

Chitosan Microspheres Incorporating Doxorubicin-Loaded Mesoporous Silica Nanoparticles as a Potential Multifunctional Platform for Postoperative Osteosarcoma Management

Abstract Osteosarcoma remains a major clinical challenge owing to its high recurrence rate, metastatic potential, and the frequent need for postoperative bone reconstruction. Here, we report a multifunctional platform consisting of doxorubicin-loaded mesoporous silica nanoparticl...

An integrated nanopore–microfluidic platform for low-voltage electroporation of delivering self-amplifying RNA into dendritic cells

Efficient delivery of large, negatively charged self-amplifying RNA (saRNA) into dendritic cells (DCs) is critical for next-generation cancer vaccines. However, this remains challenging due to the high sensitivity of DCs to chemical carriers and high-voltage electroporation. In t...

Cumulative exposure of the combined triglyceride-glucose and frailty index for incident hypertension prediction in middle-aged and older adults: a national cohort study

Insulin resistance and frailty are both independently associated with elevated blood pressure, yet the combined and cumulative impact of these conditions on incident hypertension remains largely unexplored. This study aimed to evaluate the association between cumulative exposure...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

A Robust Mitochondria‐Targeted Photosensitizer Synergizes With Cisplatin Chemotherapy for Enhanced Antitumor Immunity

ABSTRACT Chemotherapy remains a major strategy for cancer treatment, with cisplatin widely used as a first‐line agent for diverse malignancies. Although cisplatin efficiently induces tumor cell death through DNA damage, its therapeutic efficacy is often limited by the development...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...