The First Affiliated Hospital, Sun Yat-sen University

A Unified Mechanistic Framework for Copper Toxicity in Neutrophils: Metabolic Rewiring, Cell-Death Crosstalk, and Immune Dysfunction

Significance: Copper is an essential redox-active micronutrient, but failure of copper compartmentalization can convert it from a catalytic cofactor into a source of oxidative, proteotoxic, and mitochondrial stress. Neutrophils are a plausible target of this transition because th...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Characteristics, treatment patterns, and outcomes of patients with transthyretin amyloidosis: a large-scale, observational, retrospective study in China (OverTTuRe China)

Abstract Background Evidence remains limited on disease journey for transthyretin (ATTR) amyloidosis in China. This study aims to analyse China data from OverTTuRe, an observational, retrospective, multi-country cohort study. Methods Data were extracted from medical records (2013...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

The NSDHL/c-Myc/PKM2 Axis Drives Glycolytic Reprogramming and Tumor Growth in Multiple Myeloma

Multiple myeloma (MM) remains largely incurable because of its complex biology and frequent disease relapse. Metabolic reprogramming is increasingly recognized as a critical contributor to MM progression. NAD (P)-dependent steroid dehydrogenase-like protein (NSDHL) has been highl...

Targeted NAD + Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions

ABSTRACT Regeneration of the injured endometrium requires re‐establishment of a permissive microenvironment that supports coordinated epithelial renewal, angiogenesis, and matrix remodeling. However, this regenerative transition remains incomplete in intrauterine adhesions, sugge...

The dawn of RAS-targeted therapy: a landmark breakthrough of daraxonrasib in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid malignancies. More than 80% of patients are diagnosed at an advanced stage, and the 5‑year survival rate remains approximately 13% [ 1 , 2 ]. For patients with metastatic PDAC (mPDAC), first-line chemotherapy...

Discordant Interleukin-27 (IL-27) Subunit Transcription in Human Sepsis Exposes a Molecular-Attribution Gap

Background/Objectives: Interleukin-27 (IL-27) is an obligate EBI3–p28 heterodimer, yet sepsis studies commonly measure and target the axis as a single entity. We tested whether both subunit transcripts are coordinately induced in septic monocytes and whether the axis has function...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Human testis-specific TTRP regulates circadian clock as an evolutionarily young natural antisense transcript of PER2

The circadian clock orchestrates a variety of physiological and behavioral processes, endowing the ability to adapt to the cycling environment. Here, we report the identification of TTRP, a TDP-43 pseudogene that emerged in higher Hominoidea species ~8.6 Mya. TTRP is a human test...

High tryptophan 2,3-dioxygenase expression promotes lenvatinib resistance in hepatocellular carcinoma

Background Lenvatinib (LEN) is a key first-line therapy for advanced hepatocellular carcinoma (HCC), but intrinsic and acquired resistance limits its long-term efficacy. We aimed to identify novel mechanisms underlying LEN resistance and to explore clinically relevant biomarkers...

HNRNPK Lactylation Amplifies Inflammation and Exacerbates Myocardial Ischemia/Reperfusion Injury by Regulating Jag2 Splicing

BACKGROUND: Myocardial ischemia/reperfusion injury triggers profound metabolic reprogramming and lactate accumulation. However, how this metabolic stress regulates inflammatory gene expression remains poorly understood. We hypothesized that lactylation, a lactate-derived posttran...

Noninvasive retinal features for early prediction of gestational diabetes mellitus: a machine learning-based cohort study

Gestational diabetes mellitus (GDM) is the most common complication during pregnancy and early prediction for high-risk gravidas is crucial to facilitate timely intervention. However, most newly discovered biomarkers require additional blood sampling and high costs, which limits...

Joint association of five insulin resistance indices and frailty index with incident cardiometabolic multimorbidity in individuals with cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study

Insulin resistance and frailty are closely related to cardiometabolic deterioration, yet their joint contribution to the development of cardiometabolic multimorbidity (CMM) among individuals with early-to-intermediate cardiovascular–kidney–metabolic (CKM) syndrome remains unclear...

A multi-temporal MRI radiomics model for early post-ablation recurrence risk stratification in hepatocellular carcinoma

OBJECTIVES: To develop and validate a multi-temporal magnetic resonance imaging (MRI)-based radiomics model for predicting one-year recurrence in hepatocellular carcinoma (HCC) after ablation. METHODS: This retrospective study included 204 patients with HCC who underwent curative...

Early inflammatory response is associated with antibiotic treatment outcomes in acute phlegmonous appendicitis: a retrospective cohort study

Acute phlegmonous appendicitis is considered an intermediate inflammatory subtype between uncomplicated and complicated appendicitis. Although nonoperative management is increasingly accepted for uncomplicated appendicitis, evidence for phlegmonous appendicitis remains limited. T...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Revisiting HAIC and systemic treatment for initially diagnosed HCC with major portal vein (Vp3/4) tumor thrombosis

Hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT) has a dismal survival expectancy. The treatment for HCC with major PVTT remains challenging. The aim of the study was to revisit the survival outcomes and safety of locoregional hepatic arterial infusio...

Inhibition of ERK5 activity ameliorates osteoarthritis by suppressing NLRP3 inflammasome-mediated chondrocyte pyroptosis

Abstract Osteoarthritis (OA) is a widespread degenerative joint disorder manifesting as chronic pain, functional impairment, and progressive disability, imposing a substantial burden on global public health. Despite extensive research, the precise molecular pathways underlying OA...

Microenvironment‐Heterogeneity‐Driven Self‐Adaptive CuMo Diatomic Nanozyme Hydrogel for NIR‐II Photoacoustic Imaging‐Assisted Periodontitis Theranostics

ABSTRACT Conventional periodontitis management relies on invasive, operator‐dependent diagnostic methods and treatments that do not adapt to the spatially heterogeneous and evolving periodontal microenvironment. To address these limitations, a heterogeneous microenvironment‐respo...