The Catholic University of Korea Seoul St. Mary's Hospital

Clinical Outcomes of Switching from Prostaglandin Analogs to Omidenepag Isopropyl in Primary Open-Angle Glaucoma and Glaucoma Suspect Patients with Prostaglandin-Associated Periorbitopathy: A Prospective, Multicenter Study

Background/Objectives: Prostaglandin-associated periorbitopathy (PAP) is a common treatment-related burden of prostaglandin analog (PGA) therapy that may compromise long-term glaucoma management. This study evaluated improvement in PAP and changes in intraocular pressure (IOP) af...

Serial ultrasonographic monitoring during defibrotide treatment of sinusoidal obstruction syndrome after hematopoietic stem cell transplantation: a longitudinal study of treatment response

Purpose: This study evaluated serial ultrasonographic (US) changes during defibrotide therapy for sinusoidal obstruction syndrome (SOS) after hematopoietic stem cell transplantation, identifying parameters whose temporal trajectories differed by treatment response.Methods: This r...

Phase IIa Trial of Locoregional High-Dose Autologous Natural Killer Cell Therapy Combined with Hepatic Arterial Infusion Chemotherapy for Locally Advanced Hepatocellular Carcinoma

PurposeHepatocellular carcinoma (HCC) refractory to locoregional therapies remains a major clinical challenge.This study evaluated the efficacy and safety of locoregional high-dose autologous natural killer (NK) cell therapy combined with hepatic arterial infusion chemotherapy (H...

Transgluteal Decompression of the Pudendal Nerve in Pudendal Neuralgia: Implications of Sacrospinous Ligament Resection

Objective: This study evaluated the efficacy of pudendal nerve decompression via the transgluteal approach for pudendal neuralgia and examined factors associated with surgical outcomes.Methods: Pain reduction was analyzed in 14 patients with pudendal neuralgia who underwent trans...

Lipid Burden and Efficacy of Preventive PCI of Vulnerable Atherosclerotic Coronary Plaques: Post Hoc Analysis From the PREVENT Trial

BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...

Interplay Between the Gut Microbiome and Oxidative Stress in Type 2 Diabetes

Type 2 diabetes (T2D) develops when pancreatic beta cells progressively fail to compensate for insulin resistance in a host environment shaped by diet, adiposity, aging, medications, and genetics. Gut microbial dysbiosis and oxidative stress are often treated as parallel abnormal...

Timing of Full Enteral Feeding and Longitudinal Gut Microbiome Development in Infants Admitted to the Neonatal Intensive Care Unit

Background/Objectives: Delayed achievement of full enteral feeding (FEF) is common in neonatal intensive care unit (NICU) infants but is closely linked to gestational age (GA). We examined whether time to FEF is associated with gut microbiome development from birth to 6 months of...

Sex and Mortality Among Patients with Papillary Thyroid Cancer

Importance Unlike patient age, which has been a well-established and routinely used primary biological prognostic factor in the risk stratification of papillary thyroid cancer (PTC), the prognostic value of patient sex remains controversial in this common endocrine malignant neop...

Trastuzumab plus nivolumab with gemcitabine and cisplatin as first-line therapy for HER2-positive unresectable biliary tract cancer: a phase 1b/2 trial

Biliary tract cancers (BTCs) are associated with poor outcomes despite recent incorporation of immune checkpoint inhibitors into first-line chemotherapy. Human epidermal growth factor receptor 2 (HER2) overexpression or amplification defines a therapeutically targetable subset of...

Ociperlimab and tislelizumab in advanced esophageal squamous cell carcinoma (AdvanTIG-203): a phase II study

Patients with esophageal squamous cell carcinoma (ESCC) have an unmet need for new therapies that improve survival. In this phase II trial, patients received ociperlimab and tislelizumab (A) or placebo and tislelizumab (B) (NCT04732494). The primary endpoint was objective respons...

Venoarterial extracorporeal membrane oxygenation for chemotherapy-induced neutropenic septic shock in children: a single-center experience

Abstract Background Venoarterial extracorporeal membrane oxygenation (VA ECMO) in pediatric septic shock patients remains controversial, particularly in children with neutropenia, because of concerns about bleeding, infection, and poor prognosis. Chemotherapy-induced neutropenia,...

PCSK9 Inhibition Attenuates Renal Oxidative Stress and Lipotoxicity in Diabetic Kidney Disease in Association with AMPK Activation

Renal lipotoxicity and oxidative stress are major contributors to diabetic kidney disease (DKD), but the role of proprotein convertase subtilisin/kexin type 9 (PCSK9) and its relationship with AMP-activated protein kinase (AMPK) signaling remain unclear. We investigated the effec...

Metabolic health, obesity, and prognosis in chronic obstructive pulmonary disease

Metabolic syndrome is a common comorbidity in chronic obstructive pulmonary disease (COPD), yet its long-term impact on survival and exacerbations remains controversial. We investigated whether metabolic health status and body mass index (BMI) influence mortality and the rate of...

Expanding the spectrum of post-HSCT hemolysis: from passenger lymphocyte syndrome to host- and graft-associated alloimmune hemolytic anemia

Abstract Immune-mediated alloimmunization and hemolytic anemia can complicate ABO-incompatible hematopoietic stem cell transplantation (HSCT). After major ABO-incompatible HSCT, clinical manifestations may include pure red cell aplasia and delayed hemolysis. Passenger lymphocyte...

Remimazolam Versus Dexmedetomidine for Monitored Anesthesia Care in Patients Undergoing Transfemoral Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial

Background/Objectives: Monitored anesthesia care is increasingly used for transfemoral transcatheter aortic valve implantation (tf-TAVI), but the optimal sedative regimen remains uncertain. We compared remimazolam with dexmedetomidine during tf-TAVI. Methods: In this single-cente...

Comparing the Efficacy and Tolerability of Two 0.3% Hyaluronic Acid Eye Drop Preparations for Dry Eye Disease: a Randomized Trial

Purpose: To evaluate the efficacy and tolerability of a new 0.3% non-preservative low viscosity hyaluronic acid (HA) preparation (Kynex 3), compared to the same concentration of HA (Hyalein Mini 0.3%) for the treatment of dry eye disease. Methods: A prospective, single-center, ra...

Extended treatment duration and recurrence in successfully treated drug-susceptible pulmonary tuberculosis with cavity on chest radiograph

Background Cavity on chest radiograph is recognized as an independent risk factor for recurrence in pulmonary tuberculosis (TB), but evidence supporting extended treatment in these patients remains limited, particularly in real-world data from Korea. Methods We performed a retros...

Adolescent arm wrestling–related medial epicondyle fractures: carrying angle and body mass index as associated anatomic and anthropometric factors

Medial epicondyle fractures during arm wrestling are rare but potentially debilitating injuries in adolescents, with previous reports limited to small case series of fewer than 10 patients. The anatomic and anthropometric factors predisposing adolescents to this injury pattern re...

Three-Year Outcomes of Drug-Eluting Stents, Drug-Coated Balloons, and Non-Drug-Eluting Devices in Native Femoropopliteal Artery Disease: An Analysis of the K-VIS ELLA Registry

Background: Although drug-eluting devices have demonstrated improved efficacy in femoropopliteal artery (FPA) disease, evidence on their long-term clinical outcomes in realworld practice remains limited.Methods: Using data from the multicenter Korean Vascular Intervention Society...

Deep Learning-Assisted Segmentation, Multiparametric MRI Radiomics, and Clinical Features for Recurrence Risk Stratification in Young-Age Breast Cancer: A Prospective Pilot Study

Purpose: To develop an exploratory prognostic model integrating multiparametric MRI radiomics and clinical features for recurrence risk stratification in young-age breast cancer (YABC). Materials and Methods: In this prospective single-institution cohort, women under 40 years wit...