The Catholic University of Korea Seoul St. Mary's Hospital

Deep Learning-Assisted Segmentation, Multiparametric MRI Radiomics, and Clinical Features for Recurrence Risk Stratification in Young-Age Breast Cancer: A Prospective Pilot Study

Purpose: To develop an exploratory prognostic model integrating multiparametric MRI radiomics and clinical features for recurrence risk stratification in young-age breast cancer (YABC). Materials and Methods: In this prospective single-institution cohort, women under 40 years wit...

Predicting clinical dementia rating scores from neuropsychological testing: a machine learning study in a large clinical cohort

To reduce variability of Clinical Dementia Rating (CDR) assessments taken from raters and informants, quantitative and reproducible approaches to support consistent interpretation are needed. We developed multiclass classification models of CDR global and regression models of CDR...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Association Between Artificial Sweetener Consumption and Bladder Cancer Risk: A Systematic Review and Meta-Analysis

Background:The potential association between artificial sweetener consumption and bladder cancer risk remains controversial.Therefore, we conducted a comprehensive metaanalysis synthesizing evidence from observational studies to elucidate this relationship.Methods: A systematic l...

Changing Clinical Characteristics, Diagnostic Patterns, and Outcomes of Tuberculosis in South Korea: The Korean Tuberculosis Cohort, 2019-2024

BACKGROUND: Tuberculosis (TB) remains a public health concern in South Korea despite declining national notifications. We evaluated temporal changes in clinical characteristics, diagnostic patterns, and treatment outcomes in the Korean Tuberculosis Cohort (KTBC) from 2019 to 2024...

Development of a multidimensional scale for discomfort related to personal protective equipment and its exploratory association with musculoskeletal symptoms among Korean healthcare workers during the COVID-19 pandemic

The COVID-19 pandemic required healthcare workers (HCWs) to use personal protective equipment (PPE) for prolonged periods, raising concerns about its possible relationship with musculoskeletal disorders (MSDs). PPE-related discomfort, however, is multidimensional, encompassing bo...

Clinical and Ultrasonographic Characterization of Proposed Sjögren’s Disease Phenotypes in a Korean Longitudinal Cohort

Background/Objectives: The objective was to determine whether previously proposed Sjögren’s disease (SjD) subgroups can be pragmatically classified using routinely available clinical and laboratory data and to evaluate their associations with salivary gland ultrasonography (SGUS)...

Integrative transcriptomic profiling reveals convergent coding and non-coding signatures in pediatric bone marrow failure syndromes

Abstract Pediatric bone marrow failure (BMF) comprises heterogeneous inherited and immune-mediated disorders, yet many cases remain genetically unclassified despite comprehensive genomic evaluation. To identify shared transcriptional features beyond protein-coding variation, we p...

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

Terminal exhaustion of CD8⁺ T cells limits the efficacy of immune checkpoint blockade (ICB), particularly in glioblastoma, which is characterized by an immunosuppressive tumor microenvironment. Therefore, a better understanding of the regulators of terminal exhaustion could overc...

Per Protocol Analysis and Long‐Term Outcomes of Laparoscopic Radical Resection for Gallbladder Cancer Compared With Open Method

BACKGROUND: Although laparoscopic radical resection for gallbladder (GB) cancer has been attempted, only a limited number of studies have evaluated its outcomes using a per-protocol analytical approach. METHODS: Between January 2010 and December 2019, 213 patients underwent surge...

Original and Modified Sauvé–Kapandji Procedures: A Two-Axis Framework for Surgical Decision-Making—A Narrative Review

The Sauvé–Kapandji (SK) procedure is a salvage operation that fuses the distal radioulnar joint (DRUJ) and creates an intentional pseudarthrosis in the proximal ulna, thereby relieving pain while preserving forearm rotation and ulnar-sided bony support. This narrative review (1)...

Hyperacute Cytokine Kinetics and Early Interleukin-10 Elevation as Predictors of Neurological Outcome in Post-Cardiac Arrest Syndrome

Background: Post-cardiac arrest syndrome (PCAS) involves a complex interplay between systemic inflammatory and compensatory anti-inflammatory responses. The hyperacute kinetics of these cytokines and their incremental prognostic value beyond established brain injury biomarkers re...

Identification of a Pathogenic RECQL4 1.6-kb Deletion–Insertion in a Neonate with Atypical Skeletal Phenotype of Baller–Gerold Syndrome Using Rapid Whole-Genome Sequencing

Mi-Ae Jang, M.D., Ph.D., Ja-Hyun Jang, M.D., Ph.D., Jin Kyu Kim, M.D., Ph.D., Joonhong Park, M.D., Ph.D., Go Hun Seo, M.D., Ph.D., Misun Yang, M.D., Ph.D., Yun Sil Chang, M.D., Ph.D., and Hyun Ho Kim, M.D., Ph.D.. Ann Lab Med -0001;0:. https://doi.org/10.3343/alm.2026.0102

Effects of Glycemic Status and Antidiabetic Agents on the Recurrence of Chronic Rhinosinusitis with Nasal Polyps: A Multicenter Study

Background Although several reports suggest that antidiabetic agents may exert anti-inflammatory effects, the influence of glycemic status and antidiabetic agents on chronic rhinosinusitis remains unexplored. Objective This study aimed to assess the impact of glycemic status and...

Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study

Purpose: Optimal management of borderline and malignant phyllodes tumors (PT) is not well established, especially regarding margin width and the use of adjuvant radiotherapy (RT).This multicenter study aimed to identify prognostic factors and to assess the effectiveness of adjuva...

Early clinical outcomes of the trans-ocular threading technique for four-point flanged scleral fixation of intraocular lenses: a case series

Abstract Purpose To evaluate the early clinical outcomes and surgical feasibility of a trans-ocular threading technique for four-point flanged scleral fixation of intraocular lenses (IOLs). Methods This retrospective case series included 12 eyes of 12 patients who underwent four-...

Maternal diabetes and childhood cancer risks in offspring: a nationwide cohort study

Maternal diabetes is associated with several adverse childhood outcomes, but its link to childhood cancer remains inconclusive. We investigated this in a nationwide birth cohort using the Korean National Health Insurance database. We analyzed women who delivered singletons betwee...