The Affiliated Yongchuan Hospital of Chongqing Medical University

One-stop colonoscopy-based management of rectal bleeding from internal hemorrhoids: a real-world comparative study

Rectal bleeding commonly prompts colonoscopy to exclude colorectal cancer before symptoms are attributed to hemorrhoids. We evaluated a one-stop, colonoscopy-based strategy for integrating diagnosis and treatment of bleeding internal hemorrhoids. We retrospectively analyzed patie...

Ultrasound‐Triggered Tendon–Bone Comb With Axially Graded Electrical Gradients for Tendon–Bone Interface Integration

ABSTRACT Loss of electrophysiological guidance from endogenous fibrous‐channeled electrical conduction critically impairs repair of the injured tendon–bone interface (TBI). Clinical analysis indicates that the inconsistent efficacy of conventional electrostimulation (ES) therapy...

Mechanistic insights into VSIR-mediated AXL regulation and gastric cancer proliferation

Gastric cancer (GC) progression is frequently driven by complex tumor microenvironment signals. Here, our study identifies V-set immunoregulatory receptor (VSIR) as a key driver of GC progression via AXL regulation. High-throughput RNA sequencing demonstrated that VSIR overexpres...

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

Abstract Expanding the repertoire of usable E3 ubiquitin ligases remains a critical challenge in the field of targeted protein degradation. For the emerging E3 ligase Kelch domain‐containing protein 2 (KLHDC2), currently reported ligands have a carboxylate moiety in common that m...

Stimuli-responsive magnetic black phosphorus-based nanoreactor for chirality-dependent anoikis induction in cancer therapy

Anoikis presents an alternative scheme for suppressing tumor metastasis. While limited by off-target effects, rapid degradation, and reactive oxygen species (ROS) accumulation, anoikis resistance remains a persistent challenge for current tumor therapy. The use of external and en...

From Metabolic Dysfunction to Vascular Remodeling

Subclinical cardiovascular disease (SCVD) encompasses a spectrum of vascular abnormalities that emerge well before the onset of overt cardiovascular events. Although a wide range of metabolic, inflammatory, and vascular markers have been associated with SCVD, current assessment s...

Assessing the content quality of Douyin and Bilibili as health information sources for pulmonary tuberculosis: a cross-sectional study

Pulmonary tuberculosis (PTB) remains a major global infectious disease, and short-video platforms are increasingly used for health information seeking. However, the quality, reliability, disease-specific accuracy, and safety of PTB-related videos on major Chinese platforms have n...

Edge-centric functional diversity alterations and associated transcriptomic profiles of pain and vertigo in the migraine spectrum

Abstract Background The migraine spectrum exhibits substantial clinical heterogeneity, encompassing pain-dominant, vertigo-dominant, and pain-vertigo overlapping manifestations, as represented here by migraine without aura (MwoA), a clinically defined adult vertigo-dominant recur...

Facilitating positive role transition: the experiences of patients with acute stroke. undergoing early rehabilitation—a qualitative study

To explore the experiences and expectations of patients with acute stroke (admitted within two weeks after stroke onset) participating in early rehabilitation, and to identify opportunities to optimize rehabilitation outcomes. A descriptive qualitative study was conducted using f...

Perioperative carbohydrate loading improves comfort without adverse metabolic or neonatal effects in gestational diabetes mellitus

Preoperative carbohydrate loading has been known to overcome discomfort and complications associated with cesarean section, but there is a scarcity of evidence on its safety and benefits in patients with gestational diabetes mellitus (GDM). In this study, pregnant women with norm...

Joint associations of comorbidity burden and polypharmacy with depressive symptoms, and joint effects of comorbidity burden, polypharmacy, and depressive symptoms on all-cause mortality among US adults aged 45 years and older: a dual cross-sectional and cohort study

Although comorbidity burden and polypharmacy are increasingly prevalent among middle-aged and older adults and may contribute to depressive symptoms, evidence on their joint associations remains scarce. Furthermore, the combined impact of comorbidity burden, polypharmacy, and dep...

Global Trends in Heart Failure Self-Care Research: A Bibliometric and Visual Analysis

Background: Adequate patient self-care is fundamental to effective heart failure (HF) management and is endorsed by international guidelines to improve clinical outcomes. Despite a growing body of evidence, the global research landscape, including publication trends, collaborativ...

Venous valve–related occlusion in thrombosed arteriovenous fistulas: outcomes of ultrasound-guided percutaneous transluminal angioplasty

Venous valve–related occlusion (VVRO) is an underdiagnosed cause of arteriovenous fistula (AVF) dysfunction in patients with end-stage renal disease (ESRD). Data regarding the long-term outcomes and prognostic factors associated with ultrasound-guided percutaneous transluminal an...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

ABSTRACT Idiopathic pediatric uveitis (IPU) is a leading cause of irreversible vision loss in children; however, the genetic and molecular mechanisms underlying this condition remain unclear. Herein, trio‐based whole‐exome sequencing was performed in 28 affected families and targ...

SNAI2/SLUG: a key regulator of endothelial-to-mesenchymal transition and vascular remodeling in cardiovascular diseases

Snail family transcriptional repressor 2 (SNAI2), also known as SLUG, is a canonical driver of epithelial-mesenchymal transition (EMT). While its oncogenic roles are well-established, emerging evidence underscores its pivotal involvement in cardiovascular diseases (CVDs). This re...

CT quantification of enlarged inguinal lymph nodes as a diagnostic approach for periprosthetic joint infection after hip arthroplasty

Periprosthetic joint infection (PJI) is a major complication following total hip arthroplasty (THA), posing significant diagnostic challenges. This study prospectively evaluated 114 patients from January 2021 to August 2023, including those with PJI and aseptic loosening, using c...

Labral Augmentation Decreases Humeral Head Displacement and Cartilage Stress in an Anterior Shoulder Instability Model With Subcritical Glenoid Bone Loss: A Finite Element Analysis

Purpose To investigate the influence of labral augmentation on glenohumeral biomechanics for anterior glenohumeral instability patients via finite element analysis (FEA). Methods A shoulder finite element model was derived from preoperative computed tomography scans of five patie...

A 9 + 1 multi-agent collaborative teaching model for clinical reasoning: integrating large language models into medical education

Clinical reasoning—the cognitive and metacognitive processes through which clinicians collect and interpret patient information, generate and test diagnostic hypotheses, and make clinical decisions—is a core competency in medical education. Since 1956, clinical educators have inn...