The Affiliated Yongchuan Hospital of Chongqing Medical University

Cross‐cultural adaptation and initial evaluation of selected measurement properties of the simplified chinese version of the knee injury and osteoarthritis outcome score joint replacement in patients with knee osteoarthritis

Abstract Purpose This study aimed to translate and culturally adapt the knee injury and osteoarthritis outcome score joint replacement (KOOS‐JR) into simplified Chinese and provide an initial evaluation of selected measurement properties in patients with knee osteoarthritis (OA)...

Low-Dose Glucocorticoids Adjunctive to Flow Diverter Therapy for Unruptured Intracranial Aneurysms Improve Cerebrovascular Outcomes

Abstract Flow diverter (FD) implantation is standard for unruptured intracranial aneurysms (UIAs), but cerebrovascular complications persist. This nested study within a prospective multicenter cohort evaluates whether short-term, low-dose glucocorticoid use is associated with cer...

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Association of sulfur microbial diet with lung cancer incidence and lung cancer-related mortality in 95,612 American adults: a prospective cohort study from the PLCO trial

The sulfur microbial diet (SMD) score is a microbiome-related dietary proxy derived from food groups associated with sulfur-metabolizing bacteria. Whether it is associated with lung cancer remains unclear. We analyzed 95,612 participants from the Prostate, Lung, Colorectal, and O...

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

ABSTRACT Intracerebral hemorrhage (ICH)‐induced secondary brain injury is driven in part by oxidative stress, blood‐brain barrier disruption, mitochondrial dysfunction, and neuronal loss. Here, we developed a brain endothelial cell membrane‐coated ROS‐responsive biomimetic nanopl...

Identification and validation of biomarkers related to integrated stress response in ischemic stroke based on transcriptomics

Abstract Ischemic stroke (IS) is a prevalent cerebrovascular disorder. Integrated stress response (ISR) plays an important role in multiple cerebrovascular diseases, its specific involvement and associated biomarkers in IS remain incompletely understood. This study aimed to ident...

Multimodal analysis identifies a fibroblast subtype enriched in EGFR-mutant NSCLC and its spatial niches

Abstract Background The tumor microenvironment (TME) in non-small cell lung cancer (NSCLC) exhibits heterogeneity across distinct oncogenic driver mutations, but whether specific stromal states are shaped by these mutations and how they influence tumor progression and therapy res...

Cross-species single-nucleus transcriptomics identifies microglial Arhgap22 as a conserved modulator of synaptic phagocytosis and depression-related behaviors

Abstract Microglia-regulated neuroinflammation is associated with major depressive disorder (MDD), yet the molecular drivers of pathological microglia-neuron interactions remain poorly defined. Here, we conducted single-nucleus RNA sequencing (snRNA-seq) of the prefrontal cortex...

Pulmonary nodules in breast cancer patients: prevalence, diagnostic intervention rate, and pathologic spectrum

Pulmonary nodules are frequently detected during staging or follow-up in breast cancer, yet their prevalence, the use of invasive diagnostic intervention, and the pathologic spectrum remain uncertain. We searched PubMed, Embase, Web of Science, Cochrane Library, and Chinese datab...

Single-Atom Nanozyme Integrated Double-Clasp Transition Probe-Driven CRISPR/Cas12a Cascade for Preamplification-Free Detection of Non-Nucleic Acid Targets

Abstract CRISPR/Cas12a diagnostics have greatly advanced nucleic acid testing, yet their extension to non-nucleic acid targets remains constrained by the intricate preamplification process and by inefficient signal transduction. Herein, we present a non-nucleic acid detection pla...

Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with limited therapeutic options. Berberine exhibits renoprotective potential, yet its precise molecular targets and mechanisms of action in DN remain unclear. Berberine targets were retrieved from TCMSP...

Construction and Exploration of the Three-Dimensional Dual Closed-Loop Safety Management System for Special Equipment

Based on the analysis of the inherent drawbacks of routine safety inspections and the objective advantages of unannounced inspections for logistics support in large medical institutions, it is concluded that proactive safety boasts broad application space and far-reaching prospec...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

ABSTRACT Joint profiling of chromatin accessibility and gene expression in the same cell enables direct linkage of regulatory elements to transcriptional output, but existing approaches remain limited by low co‐capture sensitivity, proprietary platforms, and high costs. Here we p...

Association between total calcium intake and depressive symptoms in cancer survivors based on the National Health and Nutrition Examination Survey (NHANES) 2007–2018: a cross-sectional study

Abstract Though previous studies have explored the relationship between Ca intake and depressive symptoms, epidemiological evidence on cancer survivors remains limited. This study aimed to investigate the association between estimated total Ca intake and depressive symptoms among...

Circulating Protein Biomarkers for Primary Cardiomyopathy: Evidence from Mendelian Randomization and Clinical Validation

BACKGROUND: Primary (non-ischemic) cardiomyopathy poses diagnostic challenges due to phenotypic heterogeneity and non-specific clinical presentation, and commonly used circulating biomarkers have limited disease specificity. The aim was to prioritize mechanism-informed plasma bio...

Regional structural–functional connectivity decoupling is associated with glymphatic-related dysfunction and cognitive performance in cerebral small vessel disease: a multimodal MRI study

Regional structural–functional connectivity (SC-FC) coupling and glymphatic-related MRI markers may provide complementary insights into cognitive impairment in cerebral small vessel disease (CSVD). However, their interrelationship and cognitive relevance remain unclear. This cros...

Development and validation of a predictive model for osteoporosis in middle-aged and older patients with type 2 diabetes mellitus: a multicenter retrospective study

The increasing prevalence of type 2 diabetes mellitus (T2DM) and osteoporosis (OP) among aging populations necessitates early OP risk identification. This study developed and validated a nomogram for predicting OP risk in middle-aged and older T2DM patients, and explored dose-res...

Health-convergence-based muscle synergy variability for quantifying neuromuscular control responses evoked by upper limb rehabilitation robot training in stroke patients

Upper limb rehabilitation robot-assisted training (UE-RAT) facilitates post-stroke motor recovery. Its efficacy is evaluated using clinical scales. However, these scales mainly reflect overall motor impairment and functional performance, lacking indices to assess patients’ neurom...

sTREM2 and GFAP mediated the association of cerebrospinal fluid GLP-1R with tau pathology in alzheimer’s disease

Glucagon-like peptide-1 receptor (GLP-1R) is involved in metabolic regulation and has also been implicated in neuroprotection and the modulation of neuroinflammatory processes in the central nervous system. GLP-1R has therefore emerged as a potential therapeutic target for Alzhei...