Technische Universität Braunschweig

Agreement and Discrepancies of Self- and Mother Reported Psychopathology from Adolescence Until Emerging Adulthood: Results of a Prospective Longitudinal Study

Abstract Discrepancies between self- and collateral reports of mental disorders are common and contain relevant information, yet the longitudinal development of informant discrepancies and associated factors remain unknown. The current study examined agreement and discrepancies b...

The Python simulations of chemistry framework: 10 years of an open-source quantum chemistry project

Over the past decade, the Python-based Simulations of Chemistry Framework (PySCF) has developed into a widely used open-source platform for electronic-structure theory and quantum chemical method development. This article reviews the major advances since the previous overview in...

Coordinated motion planning: Multi-agent path finding in a densely packed, bounded domain

Abstract We study Multi-Agent Path Finding for arrangements of labeled agents in the interior of a simply connected domain: Given a unique start and target position for each agent, the goal is to find a sequence of parallel, collision-free agent motions that minimizes the overall...

Arp2/3 complex-dependent actin remodeling is required for efficient RSV uncoating in A549 cells

ABSTRACT Productive human respiratory syncytial virus (RSV) cell entry requires coordinated interactions between viral proteins and host-cell factors at the plasma membrane-actin cortex interface. Branched actin networks remodel this interface, but their precise contribution to t...

High-cell-density Escherichia coli–based nanobody production: benchmarking of subcellular targeting, strain background and process development strategies

Abstract Background Nanobodies (NB) are compact single-domain antibody fragments with substantial diagnostic and therapeutic potential, but scalable microbial production under controlled bioreactor conditions remains insufficiently characterized. In this study a high-cell-density...

MEmilio: a high performance Modular EpideMIcs simuLatIOn software for multi-scale and comparative simulations of infectious disease dynamics

Abstract Epidemic and pandemic preparedness with rapid outbreak response rely on timely, trustworthy evidence. Mathematical models are crucial for supporting timely and reliable evidence generation for public health decision-making with models spanning approaches from compartment...

Airborne measurements for investigating offshore wind farm wakes and modifications of sea state – benefits and limitations

Abstract. In the framework of the two large wind energy research projects WIPAFF and X-Wakes, crewed airborne measurements have been performed in and around wind farm clusters of the German Bight to investigate offshore wind farm wakes and associated sea-state modifications. Thes...

Constrained Close Loop Model Predictive Control Architecture for Deformable Linear Objects for Dynamic Motions

Deformable linear objects (DLOs) exhibit highly nonlinear dynamic behavior, complicating their control during high-speed maneuvers. Furthermore, the lack of a generic spatial representation and the difficulty of real-time state estimation hinder effective closed-loop manipulation...

A decision-support framework for selecting new energy bus technologies: Assessing battery electric and hydrogen fuel cell buses

New energy bus (NEB) technologies, including battery electric buses (BEBs) and hydrogen fuel cell buses (FCBs), offer pathways to support decarbonisation strategies in public transport. Selecting the most suitable technology represents a multi-dimensional decision problem encompa...

Monitoring the Shear Behavior of Reinforced Concrete Beams Using Fiber Optic Sensors Installed in the Compression Zone

A variety of measurement systems are available for monitoring existing concrete bridges with deficiencies in shear capacity. In addition to established systems, fiber optic sensors (FOS) offer significant potential for structural health monitoring. However, FOSs are often install...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...