Technical University of Denmark

Seaweed (Saccharina latissima) modulates the microbiome composition during fecal fermentation with limited effect of common processing methods

Seaweed fibers show promising effects on gut health, but it is unclear if processing of whole seaweed changes the nutrient accessibility for gut microbiota. This study investigated the effects of processed Saccharina latissima on the fecal microbiome composition and metabolic act...

On the effects of bat protection strategies on energy production and structural loads of wind farms

Abstract. As wind energy deployment expands, bat protection curtailment is increasingly required for ecological and regulatory reasons. Operators typically implement static, also called 'blanket', schedules based on environmental thresholds for predefined periods, while dynamic a...

The AWAKEN wind farm benchmark – Part 2: Modeling results

Abstract. Accurately modeling wind farm performance in complex atmospheric flows remains a challenge. This paper presents the modeling results of the American WAKE experimeNt (AWAKEN) wind farm benchmark, a collaborative effort involving 16 research groups from academia and indus...

Techno-economic feasibility of offshore wind-based ammonia production for La Guajira, North Sea, and Gulf of Roses

This study evaluates the techno-economic feasibility of offshore wind-based ammonia production in 2035 and 2050. A pseudo-dynamic modeling framework with capacity optimization is applied to three offshore sites in Colombia, Denmark, and Spain using long-term wind data to capture...

Mechanistic study of mixed lithium halides solid-state electrolytes

Lithium halides with the general formula LixMyX6}, where M indicates metal ions and X halide anions are very actively studied as solid-state electrolytes, because of relatively low cost, high stability and Li conductivity. The structure and properties of these halide-based solid...

Uncovering dynamic human brain phase coherence networks

Abstract Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal am...

Beyond benchmarking: an expert-guided consensus approach to spatially aware clustering

Spatial omics technologies have revolutionized the study of tissue architecture and cellular heterogeneity by integrating molecular profiles with spatial localization. In spatially resolved transcriptomics, delineating higher-order anatomical structures is critical for understand...

RNA and lipid composition analyses reveal distinct profiles between HEK293-derived extracellular vesicles and HIV-1 Gag virus-like particles

Extracellular vesicles (EVs) and HIV-1 Gag virus-like particles (VLPs) represent promising platforms for therapeutic delivery and vaccine development. However, their molecular cargo may critically influence their biological properties and clinical applicability. In this study, a...

Evaluation of a human slow-release buprenorphine formulation in rats – tactile sensitivity and plasma concentration

Abstract Background Opioids are considered ideal for managing moderate to severe post-operative pain in laboratory rodents, with buprenorphine being one of the most commonly used analgesics in rats. A long-acting buprenorphine formulation would be highly beneficial to avoid frequ...

Performance results of communication based train control (CBTC) on the Copenhagen suburban railways

The Danish national railway infrastructure operator, Banedanmark, replaced the signals on a 171 km suburban railway network with CBTC (Communications Based Train Control) over a six-year period from 2016 to 2022. A detailed statistical analysis of the public traffic disruption da...

Formulation of energy exertion in bicycle networks and estimation of its impact on route choices

Abstract Despite strong indirect evidence that physical energy exertion shapes cycling behaviour, it has never been explicitly incorporated into route choice models. This paper introduces a generalisable, individual-specific, physics-based energy model that computes expected ener...

Modular design and supervisory control for enhanced economic resilience in continuous pharmaceutical manufacturing

Abstract Conventional continuous plants use fixed‐capacity equipment, resulting in high capital risk and suboptimal performance under fluctuating demands. To address these, this study proposes an integrated framework for modular process design and supervisory control capable of a...

Latent paths in mode choice models: incorporating street-level environment features for active travel policy

There is growing empirical evidence that walking and cycling are influenced by street-level environment features such as greenness and traffic stress. To assess active travel policy, these features are increasingly incorporated into mode choice models through predictors that aggr...

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...

Localized brain delivery of drugs via focused ultrasound-responsive bi-layer nanobubbles

Focused ultrasound (FUS) in combination with micro- or nanobubbles is a promising strategy for transiently and non-invasively opening the blood-brain barrier (BBB) to enable targeted drug delivery to the brain. Here, we report a FUS-responsive delivery system using bi-layer nanob...

Sources and sinks of dissolved oxygen in eutrophic tropical earthen fishponds

Dissolved oxygen is the main limiting factor in pond aquaculture production, yet the relative contributions of its various sources and sinks remain poorly quantified in eutrophic earthen pond systems. Photosynthetic oxygen production, surface exchange, sediment oxygen demand and...

Strong Lead‐Free Bioinspired Piezoceramics for Durable Energy Transducers

ABSTRACT Durable, high‐performance, and environmentally friendly lead‐free piezoceramics are essential for next‐generation sustainable energy transducers and electromechanical systems. However, piezoceramics are mechanically weak, which negatively impacts their working conditions...

Contrast-free super-resolution ultrasound imaging for microvascular assessment of murine subcutaneous tumour models in preclinical oncology

<title>Abstract</title> <bold>Introduction</bold> . Tumour vascularity is an important biomarker of tumour growth and therapeutic response. Current in vivo imaging methods have a limited ability to detect individual tumour vessels due to the small vessel size and low flow rates c...

Microbial inoculants for soil restoration: A Risk-Proportional Stewardship Framework Integrating Strain-Resolved Genomics and Adaptive Governance

Abstract Global soil degradation and increasing reliance on chemical inputs threaten agricultural sustainability, driving interest in microbial inoculants as tools for soil restoration. These biological products have the potential to enhance nutrient cycling, improve soil structu...

Rhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes

Abstract Signalling via the epidermal growth factor receptor (EGFR) is indispensable for morphogenesis and tissue homeostasis. It is activated by extracellular ligands, typically released from transmembrane precursors by proteolysis. Ligand shedding activity is provided by the co...