Stomatology Hospital

The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent malignancy worldwide, encompassing tumors derived from the mucosal epithelia of the oral cavity, pharynx, larynx and other head and neck regions. Most patients are diagnosed at an advanced stage due t...

Longitudinal Study on Post‐Traumatic Stress Disorder, Anxiety, and Depression Among Medical Staff in China

ABSTRACT Background Evidence of the longitudinal relationship between anxiety, depression, and post‐traumatic stress disorder (PTSD) is not uniform. This study aimed to explore the dynamic changes, independent factors, and bidirectional predictive relationships of anxiety, depres...

Dentoalveolar surgery education in Chinese undergraduate dental schools: a national survey of curriculum structure, simulation training and assessment

Dentoalveolar surgery is a core component of undergraduate dental education; however, evidence regarding its implementation in Chinese dental schools remains limited. This study investigated curriculum structure, teaching methods, simulation training, and assessment strategies fo...

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

ABSTRACT Despite architectural advances, current nerve guidance conduits inadequately replicate the mechanoactive microenvironment required for functional neural regeneration. While membrane tension is increasingly recognized as an important biomechanical regulator of axonal exte...

Role of T Cells in Chronic Pain: Mechanisms, Regulation, and Therapeutic Implications

ABSTRACT T cells are critical for controlling the adaptive immune response and maintaining the homeostasis of the body. Recent evidence suggests that T cells are involved in the initiation, maintenance, and resolution of chronic pain by releasing mediators such as cytokines and e...

Mobile health interventions for oral health-related behavior management in adolescents with fixed orthodontic appliances: a scoping review

To map the characteristics of mobile health interventions for oral health-related behavior management among adolescents undergoing fixed orthodontic treatment, identify the behavior change techniques embedded within these interventions, and summarize the reported behavioral, clin...

A tendon-targeted zwitterionic nanogel for restraining osteoclast maturation to halt heterotopic bone formation

Tendinopathy is a prevalent degenerative musculoskeletal disorder that can progress to heterotopic ossification (HO), ultimately resulting in tissue stiffening and biomechanical deterioration. However, effective early-stage therapeutic strategies to prevent pathological ossificat...

Surface Modification of Sulfonated Carbon Fiber-Reinforced Polyetheretherketone Composite by Polydopamine-Assisted nHA/Zn/CMCS and Its Evaluation of Osteogenic Properties

OBJECTIVE: Carbon fiber-reinforced polyetheretherketone (CF/PEEK) possesses the elastic modulus similar to that of natural bone, yet its inherent surface hydrophobicity and bio-inertness restrict its application in oral implantation. To overcome this limitation, this study propos...

Burden of Lip, Oral Cavity, and Pharyngeal Cancers in China: Estimated in 2022 and Projections to 2050

Introduction and Aims Lip, oral cavity, and pharyngeal (LOCP) cancers comprise a heterogeneous group of malignancies with a substantial and evolving disease burden in China. This study aimed to systematically evaluate the burden of LOCP cancers in China and to project future tren...

Development and benchmark validation of PubChat for PubMed-grounded multilingual biomedical literature retrieval

The rapid growth of biomedical literature has rendered traditional systematic reviews unsustainable. Although large language models (LLMs) offer automation potential, citation fabrication and unreliable evidence discrimination remain critical barriers. Here, using PubChat as a Pu...

Microenvironment‐Heterogeneity‐Driven Self‐Adaptive CuMo Diatomic Nanozyme Hydrogel for NIR‐II Photoacoustic Imaging‐Assisted Periodontitis Theranostics

ABSTRACT Conventional periodontitis management relies on invasive, operator‐dependent diagnostic methods and treatments that do not adapt to the spatially heterogeneous and evolving periodontal microenvironment. To address these limitations, a heterogeneous microenvironment‐respo...

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Pathological cartilage calcification represents a pivotal pathological alteration in osteoarthritis (OA), yet its underlying mechanisms remain poorly understood. Exosomes are involved in facilitating calcification, and their biogenesis may be linked to autophagy disruption. Howev...

Global trends and burden of dental caries in permanent teeth (1990–2021)

This study aims to analyze the incidence, prevalence, and years lost due to disability (YLDs) of permanent dental caries using Global Burden of Disease data, and to investigate its correlation with socioeconomic indicators. Data were obtained from the Global Burden of Disease (GB...

Application of an improved problem-based learning method in clinical endodontic training of standardized residents

Abstract Standardized residency training in stomatology is essential for developing competent dental professionals; however, improving clinical skills effectively remains a challenge in dental education. In this study, we implemented an improved problem-based learning (PBL) appro...

Virological suppression among people living with HIV monitored through routine viral load testing in seven districts of Western Province, Zambia: a geospatial and programmatic analysis of kaoma pcr laboratory data, January-December 2025

Achieving and sustaining virological suppression among people living with HIV (PLHIV) receiving antiretroviral therapy (ART) is essential for improving clinical outcomes, reducing HIV transmission, and achieving the UNAIDS 95-95-95 targets. Although Zambia has expanded routine vi...

Mechanobiology of orofacial tissues: principles, mechanisms, and therapeutic applications

The orofacial system is constantly subjected to complex and dynamic mechanical forces and exhibits highly specialized mechanosensory and mechanoresponsive behaviors. However, current studies are mostly limited to single tissues or specific pathway analyses, which are insufficient...

From gingiva to brain: cadmium promotes stroke via vascular mechanisms in periodontitis while vitamin k protects

Abstract Aim To investigate systemic circulatory vascular immune mediators associated with the periodontitis–stroke link and to elucidate underlying cellular mechanisms. Methods We analyzed 4,164 adults from NHANES 2009–2014 using multivariable regression, restricted cubic spline...

Systemic and local oxidative stress biomarkers in periodontitis: an updated systematic review and meta-analysis

To update and extend our previously published 2019 systematic review by evaluating oxidative stress (OS) biomarkers in saliva, gingival crevicular fluid (GCF), and blood in relation to periodontitis. We systematically searched five electronic databases including PubMed, Scopus, E...

Functional effects of microbial metabolites in dental caries

Dental caries is a multifactorial disease primarily driven by the metabolic activity of microorganisms within oral biofilms. The carious process begins when fermentable carbohydrates are metabolized by microbes, leading to the production of organic acids that lower the local pH a...

Two‐ to six‐year outcomes of tunnel technique with connective tissue graft in multiple mandibular anterior recessions

Abstract Background The purpose of this study is to report the 2–6 year outcomes of the tunnel technique with a connective tissue graft (TUN+CTG) in treating multiple Cairo recession type 1 and 2 recessions over a 2–6 year follow‐up, and the influence of CTG exposure on treatment...