Stomatology Hospital

Osteoporosis treatment via programmed delivery of IRF5 siRNA to macrophages in bone tissue combined with ROS scavenging

Postmenopausal osteoporosis (PO) is not merely a consequence of increased osteoclast activity. Estrogen deficiency induces oxidative stress and pro-inflammatory M1 macrophage polarization in bone tissue, thereby sustaining osteoclastogenic stimuli and pathological bone resorption...

3D Microfluidic Networks Formed by Mechanically Guided Compressive Buckling for Large‐Scale Perfused Tissue Culture

ABSTRACT Engineered tissues and organoids offer transformative potential for drug screening and regenerative medicine, yet their application is constrained by limited size and slow maturation. Despite the development of various channel networks for large‐scale engineered tissue p...

Perceptions of Surgeons in Vietnam on International Medical Volunteers

Objective: Short-term surgical missions (STMs) have been used by various organizations to address gaps in the surgical workforce in low- and middle-income countries (LMICs). However, the literature is inadequate in documenting host communities' perceptions of STMs. We aimed to un...

Unleashing the Potential of Autologous Platelet Concentrates in Bone Regeneration: A Focus on Their Synergy With Biomaterials

ABSTRACT Bone defects present significant clinical challenges worldwide, as conventional treatments such as autografts and allografts are constrained by limited supply, immune risks and insufficient bioactivity. Derived from the patient's own venous blood via centrifugation, auto...

Effect of mechanical debridement combined with Er,Cr:YSGG laser on radiographic marginal bone level in patients with peri-implantitis

Purpose To evaluate the effect of MD combined with ECL on radiographic marginal bone level (MBL) and clinical outcomes in patients with peri-implantitis. Methods This retrospective, non-randomized cohort study included 180 patients with peri-implantitis (104 in MD group, 76 in MD...

New periodontal phenotype classification in patients with different types of malocclusion and dental crowding

Abstract Background The periodontal phenotype plays a critical role in periodontal stability and orthodontic risk assessment. However, an integrated evaluation of soft‐ and hard‐tissue periodontal characteristics across various sagittal and vertical skeletal patterns and dental c...

PAK4 exacerbates melanoma immunosuppression by promoting exosome release

Melanoma remains a lethal malignancy with frequent resistance to immune checkpoint blockade therapy. Clinical evidence associates elevated PAK4 expression with poor response to anti-PD-1 treatment in melanoma patients. While tumor-derived exosomes are recognized as key immunosupp...

Rutin-magnesium complex promotes cranial bone defect repair via coordinated osteogenic and angiogenic regulation

Critical-size bone defects remain a major clinical challenge, as the current regenerative strategies such as bone grafts, biomaterials, and exogenous cells still have limitations. Emerging evidence suggests that focusing local cells and enhancing their osteogenic and angiogenic a...

Knowledge and attitudes about artificial intelligence and its applications among Chinese endodontic practitioners: a cross - sectional survey

Artificial intelligence (AI) has been increasingly applied in dentistry, including cariology and endodontics. However, evidence remains limited regarding endodontic practitioners’ AI literacy, perceptions, clinical usage, and barriers to AI integration. This study aimed to invest...

Light‐Synergistic Enhanced Synaptic Devices Toward Superadditive In‐Sensor Computing

ABSTRACT Conventional neuromorphic devices face challenges in achieving efficient integration of light sensing and synaptic computation because of structural and material limitations. In this work, we developed an indium‐tin‐zinc oxide/transparent gelatin electrolyte synaptic tra...

Femtosecond laser photoporation enables efficient delivery of apoptotic vesicles for enhanced osteogenesis

Abstract A major barrier to the translation of vesicle-based therapeutics in regenerative medicine is the ability to achieve efficient intracellular delivery without compromising, and ideally amplifying, biological activity. As a bioactive class of cell-derived vesicles with pro-...

Biotactic Nanodrugs Induce Tumor‐Localized and Durable Embolization via Programmatic Participation in Physiological Biochemical Reactions

The clinical application of tumor vascular obstruction therapy (TVOT) is mainly hindered by imprecise obstruction localization and transient embolic effects. We developed a biotactic nanodrug termed PDA-A@Fib to achieve precise and sustained TVOT by programmatically participating...

Advances in osteoimmunomodulatory biomaterials for periodontal bone regeneration

Abstract Periodontal disease is a highly prevalent chronic inflammatory condition worldwide, significantly impairing patients’ quality of life and imposing a substantial burden on healthcare systems. In recent years, significant progress has been made in the immunopathogenesis of...

Involvement of the MAPK8-Caspase‑3 Apoptotic Pathway in Arecoline‑Associated Periodontitis

Aims Arecoline, a major betel nut-derived alkaloid associated with betel nut chewing, is linked to increased periodontitis severity, but the molecular mechanisms by which it contributes to periodontitis progression remain unclear. Materials and methods Arecoline- and periodontiti...

Motion‐Robust Multichannel sEMG Array for High‐Fidelity Muscle Fatigue Monitoring

ABSTRACT Real‐time muscle fatigue monitoring during dynamic activities is critical for preventing injury and optimizing performance, yet remains hindered by motion‐induced signal artifacts in conventional wearable systems. Here, we present a motion‐robust, multichannel surface el...

Interferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK – mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis‐Related Bone Marrow Adiposity

ABSTRACT Increased bone marrow adiposity is a characteristic of osteoporosis and negatively regulates osteogenesis. Bone marrow mesenchymal stem cells (BMSCs) give rise to bone marrow adipocytes. The transcription factor interferon regulatory factor 1 (IRF1) modulates multiple bi...

Donor‐Site Outcomes of the Superficial Circumflex Iliac Artery Perforator Flap Versus Radial Forearm Flap in Unilateral Tongue Reconstruction: A Propensity Score Matching Analysis

ABSTRACT Background We compared the superficial circumflex iliac artery perforator (SCIP) flap with the radial forearm flap (RFF) to identify limitations restricting its widespread use. Methods We retrospectively evaluated unilateral tongue reconstruction using propensity score m...

SCFJFK regulates osteoblast differentiation through targeting RUNX2

RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone for...

Inhibition of Jaw Bone Marrow Mesenchymal Stem Cell Cuproptosis Attenuates Bone Loss in Apical Periodontitis via Suppressing the FoxO Signalling Pathway

ABSTRACT Aim Apical periodontitis (AP) is an infectious disorder characterized by periapical inflammation and alveolar bone destruction. Recent evidence suggests that cuproptosis, a distinctive form of copper‐regulated cell death, has been implicated in the regulation of bone los...

An assessment of blended learning of Stomatology for non-stomatology medical students

Abstract Introduction and aims The COVID-19 pandemic accelerated the adoption of blended learning in medical education, highlighting its potential to address challenges in traditional pedagogy. This study evaluates the effectiveness of blended learning for non-dental medical stud...