Stomatology Hospital

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Engineering Biomimetic Tumor Organoids Inspired by Janus Stiffness–Driven Cell Stemness

ABSTRACT Organoids become powerful platforms for modeling cancer biology but poorly preserve stemness due to inadequate biophysical cues. Cancer stem cells (CSCs), crucial for tumor growth, are rare and lose stemness under conventional in vitro conditions, limiting drug screening...

Two‐ to six‐year outcomes of tunnel technique with connective tissue graft in multiple mandibular anterior recessions

Abstract Background The purpose of this study is to report the 2–6 year outcomes of the tunnel technique with a connective tissue graft (TUN+CTG) in treating multiple Cairo recession type 1 and 2 recessions over a 2–6 year follow‐up, and the influence of CTG exposure on treatment...

Emerging and Re‐Emerging Viral Pathogens in Oncolytic Virotherapy: A Comprehensive Review

Oncolytic virotherapy has recently emerged as a promising immuno-oncological strategy, utilising the natural cytolytic potentials of viral pathogens to selectively target and destroy malignant cells. Although various engineered viruses, such as adenoviruses, vaccinia virus, and h...

Dentoalveolar and skeletal changes after customized elastodontic appliance therapy in mixed dentition children with maxillary transverse deficiency: a retrospective CBCT study

Abstract Background This exploratory study aimed to evaluate the expansion effects of a customized elastodontic appliance (CEA) on maxillary and mandibular arches in mixed dentition children using cone-beam computed tomography (CBCT), and to clarify whether these effects are dent...

Spatial ecotype in tumor immune exclusion: from spatial architecture to therapeutic strategies

The tumor microenvironment (TME) exhibits widespread immunophenotypic heterogeneity. Based on the spatial immune contexture, tumor immune profiles can be classified as immune-inflamed, excluded, or desert. Immune-excluded tumors, a distinct tumor immune phenotype, are characteriz...

Machine learning-based analysis of behavioral and dental plaque microbiome features associated with dental caries in 5-year-old children from urban and rural Yunnan

This study aimed to integrate questionnaire-based oral health behavior data with dental plaque microbiome profiles to identify behavioral and microbiological factors associated with dental caries among 5-year-old children from urban and rural areas of Yunnan Province. It also eva...

Analgesic efficacy of 0.75% ropivacaine versus 2% lidocaine after unilateral mandibular third molar extraction: a prospective observational cohort study

This prospective observational cohort study aimed to evaluate the clinical efficacy of 0.75% ropivacaine in unilateral mandibular third molar extraction and to compare its postoperative analgesic outcomes with those of 2% lidocaine. A total of 128 patients undergoing unilateral m...

Age-related prognostic disparities in cutaneous melanoma: A population-based study and validated interactive web-based nomogram for individualized prognostic stratification

Background Cutaneous melanoma (CM) in older adults (≥65 years) has distinct clinicopathological features and poorer survival than in younger adults. We evaluated age-related cancer-specific survival (CSS), prognostic associations, and an interactive web-based nomogram. Methods We...

Outcome of cusp coverage restorations on endodontically treated premolars with cervical defects: a retrospective study

This study aimed to assess the outcome of cusp coverage restorations on endodontically treated premolars with cervical defects after 6–24 months of follow-up. A total of 40 premolars with cervical defects from 28 patients who received endodontic treatment and cusp coverage restor...

Assessment of masticatory muscle activity and mandibular border movement in skeletal class II malocclusion adolescents with mandibular retrognathia

<title>Abstract</title> Objective To investigate masticatory muscle activity and mandibular border movement in adolescents with skeletal class II malocclusion and mandibular retrognathia and explore the influence of mandibular retrognathia on masticatory system function. Methods...

The germ layer: foundation of mesenchymal stem cell therapeutic destiny

Abstract Stem cells represent a pivotal resource in clinical applications. Accumulating evidence indicates that their functional properties are closely associated with their tissue origin, particularly embryonic germ layer specification, which may govern the developmental heterog...

Senescence-related immunosuppressive gene MFAP2 orchestrates stromal-immune crosstalk and immunotherapy resistance in gastric cancer

Abstract Background Gastric cancer (GC) is a leading cause of cancer-related mortality worldwide, with poor prognosis and immune checkpoint inhibitor (ICI) resistance mediated by immune escape. Senescence-related immunosuppressive genes (SRIGs) regulate the tumor microenvironment...

Methionine addiction in oral squamous cell carcinoma: a metabolic vulnerability targeted by engineered bacteria

Metabolic reprogramming is a defining hallmark of malignant transformation, and tumor-specific amino acid addiction has emerged as a promising therapeutic axis for precision oncology. Oral squamous cell carcinoma (OSCC) is an aggressive head and neck malignancy marked by limited...

Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles

During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report that conditional deletion of Mdm2, an E3...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...

Spatiotemporal Sonodynamic‐Nanozymic Therapy for Infected Jawbone Defects

ABSTRACT Infectious jawbone defects, arising from open fractures, surgical contamination, or hematogenous pathogen spread, represent severe orthopedic complications characterized by concurrent bone loss and chronic infection. Precise control of pathogen colonization, effective mo...