Institution
Shenzhen University Health Science Center
Recent research
- BiologyOpen access
Cisplatin-based chemotherapy remains a cornerstone for the treatment of advanced bladder cancer; however, the emergence of resistance severely limits its clinical efficacy. Ferroptosis suppression has been implicated in chemotherapy resistance, yet the upstream epitranscriptomic...
- Health & MedicineOpen access
Alzheimer’s disease (AD) exhibits substantial heterogeneity in functional impairment and behavioral symptoms beyond cognitive decline. However, clinically interpretable approaches for characterizing functional–behavioral heterogeneity in real-world inpatient settings remain limit...
- BiologyOpen access
Abstract AT-rich interactive domain-containing protein 1B (ARID1B) has been implicated in DNA damage repair; however, its precise molecular mechanisms and contributions to small cell lung cancer (SCLC) pathogenesis remain incompletely defined. In this study, analysis of clinical...
- Health & Medicine
Abstract Objectives To establish and validate age- and sex-specific reference intervals (RIs) for eight common tumor markers using large-scale real-world data (RWD) and to compare the performance of five indirect statistical algorithms for RI derivation. Methods This retrospectiv...
- Health & MedicineOpen access
ASFV early infection dynamically remodels host chromatin architecture to evade immune responses
African swine fever (ASF), a lethal and highly contagious viral disease, continues to inflict substantial economic losses on the global swine industry. The etiological agent African swine fever virus (ASFV), a member of the nucleocytoplasmic large DNA viruses (NCLDV) family, prim...
- Health & MedicineOpen access
Toxicities of cancer immunotherapy: clinical manifestations, underlying mechanisms, and management
Abstract Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has transformed the treatment landscape of multiple malignancies. However, dysregulated immune activation can cause a wide range of toxicities tha...
- Health & MedicineOpen access
Abstract Accurate vessel segmentation is crucial for diagnosing vascular diseases and supporting research in developmental biology. However, existing methods struggle to preserve fine capillaries and the topological continuity of vascular structures. In this study, we aim to deve...
- Health & MedicineOpen access
This software record contains the custom R scripts and curated study-level tables used to reproduce the revised Bayesian network meta-analysis reported in “Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response.” The workflow...
- Health & MedicineOpen access
This software record contains the custom R scripts and curated study-level tables used to reproduce the revised Bayesian network meta-analysis reported in “Comparative Network Meta-Analysis of Immunotherapy and Targeted Agents for Glioblastoma Survival and Response.” The workflow...
- Health & MedicineOpen access
The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...
- Society & EconomicsOpen access
Reliability and Validity of the Chinese Version of the ERS-ACA Scale Among Chinese College Students
Chinese university students face academic, employment, and interpersonal pressures that may increase their vulnerability to anxiety and depression. Artistic creative activities (ACAs) provide contexts in which individuals may regulate emotions, but the strategies used during thes...
- Engineering & Technology
ABSTRACT The facile construction of high‐performance photothermal nanozymes that simultaneously possess hollow architectures and heterojunction structures is highly appealing for tumor therapy. Herein, sulfur‐mediated hollow engineering was used to fabricate S‐FeSe 2 /CuCoSe 2 he...
- Climate & EnvironmentOpen access
Children are vulnerable to indoor environmental exposures, yet evidence from direct measurements in residential environments remains limited. This study included 115 observations from 74 children in Shenzhen during 2023–2024, with 111 observations available for regression-based a...
- BiologyOpen access
Abstract Mitochondrial inner-membrane ultrastructure plays a central role in cellular metabolism, aging, and cell death. However, super-resolution imaging of mitochondria after fixation remains challenging: commercially available fixable probes often lack sufficient reactivity fo...
- BiologyOpen access
Microglia, the resident immune cells of the central nervous system, play pivotal roles in brain surveillance and injury responses through highly dynamic process motility. Here, we investigated the role of Ca 2 ⁺ signaling in mediating microglial process motility under both physio...
- Health & MedicineOpen access
Clinical outcomes and molecular features of CEBPA-mutated MPAL: a multi-center case series
Mixed phenotype acute leukemia (MPAL) is rare and aggressive, with no standard therapy. CEBPA mutations define favorable-risk AML, but their significance in MPAL is unknown. We reviewed eight CEBPA -mutated MPAL patients from five Chinese centers. Four received allo-HSCT in first...
- BiologyOpen access
Abstract Genome-wide association studies (GWAS) have revealed extensive polygenic signals and overlapping genetic architectures across human traits, creating a need for resources that connect trait-level genetic relationships with gene-level functional evidence. Here, we develope...
- Climate & Environment
Nonradical peroxymonosulfate (PMS) activation provides a selective route for micropollutant degradation, yet the orbital-level origin of oxidant speciation at single-atom sites remains unclear. Herein, an asymmetric Fe single-atom catalyst (Fe-N3-VN-C) is synthesized via molten-s...
- Health & MedicineOpen access
Uncertainty-inspired open-set model for identifying infantile fundus abnormalities
Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we ai...
- BiologyOpen access
Abstract Background Diabetic cardiomyopathy (DCM) is defined by progressive cardiac dysfunction driven by myocardial ATP depletion, where mitochondrial electron transport chain (ETC) Complex I dysfunction acts as a critical factor. Protein arginine methyltransferase 5 (PRMT5) mai...