Shenzhen Institutes of Advanced Technology

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...

An orthogonal transcription system enables high-efficiency rescue of measles virus-based vaccine vectors against multiple pathogens

Recombinant measles virus (rMeV) vectors are promising platforms for vaccine development against emerging infectious diseases due to their safety, stability, and potent immunogenicity. However, conventional rMeV rescue systems frequently exhibit low efficiency, thereby constraini...

Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes

Aims: To clarify the immunomodulatory mechanisms by which tibial cortex transverse transport (TTT) accelerates wound healing in a type 2 diabetic rat model, with particular focus on the dynamics of subsets of monocytes and macrophages. Methods: A total of 186 male Sprague-Dawley...

An inverse design method for electric machines based on conditional variational autoencoder

Electric machines play a key role in electromechanical energy conversion across modern industrial systems. Conventional design methodologies typically involve many repetitive tasks that exhibit low computational efficiency. To address this challenge, this paper proposes an invers...

The transcription factor C/EBPβ promotes hyperglycemia-elicited glycolysis and liver cancer progression

Abstract Hyperglycemia and its related diseases, such as diabetes, dramatically accelerate cancer progression. However, the underlying mechanisms remain poorly understood, and the development of anticancer therapies based on them has largely stalled. Transcription factor CCAAT/en...