Shenzhen Institutes of Advanced Technology

Nano-NucleOTAC-mediated Z-DNA transformation disrupts mycobacterium tuberculosis biofilms and activates antibacterial immunity

The biofilms of Mycobacterium Tuberculosis (Mtb) use extracellular DNA (eDNA) as a protective structural scaffold that shields resident bacteria from host immunity and antibiotics, promoting persistent infection. An FDA-approved DNase can partially hydrolyze eDNA but has limited...

CD147 exacerbates ischemic brain injury and disrupts Wnt/β-catenin signaling and blood-brain barrier integrity

Abstract Ischemic stroke is a leading cause of death and disability, with limited therapies beyond reperfusion. CD147 (Basigin), upregulated after cerebral ischemia, participates in neuroinflammation, however, its precise contributions to blood-brain barrier (BBB) disruption and...

Integrating bioinformatics and experiments to identify neddylation-related prognostic features in prostate adenocarcinoma

Targeting neddylation represents a promising treatment strategy for prostate adenocarcinoma (PRAD). This study integrated bioinformatics and experimental approaches to identify neddylation-related prognostic genes in PRAD, with the goal of providing new insights. Public datasets...

Solution-Shearing Ordered Semiconducting Nanofibrous Blend Films for Fully Stretchable Thin-Film Transistors

Abstract High-mobility stretchable organic semiconducting materials are the core components of stretchable organic thin-film transistors, which have wide applications in wearable devices and electronic skin. It is a challenge for organic semiconducting materials to achieve both h...

ACR-Nav: Localization-Free Corridor Navigation via Action-Conditioned Scalar-Range Evolution

Mapless navigation often removes global maps while retaining localization-derived goal vectors or bearings. We study a stricter setting in which a mobile robot observes only local LiDAR, scalar goal range, and short histories of executed actions; neither pose nor goal direction i...

Dynamic coupling enables impulsive ejection in a hydrogel catapult

Abstract Ejection dynamics can provide miniature robots with high-speed, cross-scale locomotion and non-contact operation. Here, we present a dynamic coupling ejection strategy for generating and transferring kinetic energy in miniature robotics. We demonstrate this strategy usin...

Intracellular Ca2⁺ dynamics are required for microglial process motility during surveillance and in response to injury

Microglia, the resident immune cells of the central nervous system, play pivotal roles in brain surveillance and injury responses through highly dynamic process motility. Here, we investigated the role of Ca 2 ⁺ signaling in mediating microglial process motility under both physio...

Central facial emotion accelerates automatic processing of multiple facial expressions: An EEG study

Automatic processing of multiple facial expressions (MFE) is essential for adaptive social interactions, enabling the rapid detection of emotional cues in complex social environments. Behavioral studies have shown that, during explicit judgments of overall emotion, faces in the c...

Presynaptic mechanisms of glycine-modulated synaptic transmission at central synapses

Glycine is a major inhibitory neurotransmitter in the central nervous system and plays a critical role in synaptic transmission and plasticity. Although its postsynaptic actions mediated by glycine receptors (GlyRs) are well characterized, the presynaptic mechanisms by which glyc...

Proton Flux Engineering for Selective CO 2 Electroreduction

ABSTRACT The carbon dioxide reduction reaction (CO 2 RR) is central to carbon valorization and renewable electricity storage, yet its selectivity, efficiency, and durability depend on coordinating proton availability with electron transfer at dynamic electrochemical interfaces. D...

Identification of a novel small-molecule modulator targeting SNX10 to inhibit osteoclastic bone resorption

Current antiresorptive therapies reduce bone loss by eliminating osteoclasts or inhibiting their formation. However, these approaches could disrupt osteoclast-osteoblast communication and cause serious complications with long-term usage. There is a need for developing new therapi...

A vascular calcification model enabled by an ex vivo vascular calcification perfusion system

Vascular calcification is a major feature of cardiovascular disease, but mechanistic studies are limited by slow and variable animal models and by ex vivo systems that insufficiently reflect physiological flow. Here, we established an ex vivo vascular calcification perfusion syst...

Multi-objective and cross-scale inverse design of temperature-control materials via physics-constrained machine learning

Abstract Temperature-control materials, notably composite phase-change materials (CPCMs), show great potential for the thermal management of next-generation power electronics. However, the synergistic optimization of multiple performance metrics still relies heavily on Edisonian...

Language-enhanced generative modeling for amyloid PET synthesis from MRI and blood biomarkers.

Assessment of amyloid pathology in Alzheimer's disease (AD) often relies on amyloid-beta positron emission tomography (Aβ-PET), but its clinical use is limited by cost and accessibility. We developed a language-enhanced generative framework to synthesize Aβ-PET images from T1-wei...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

Programmable RNA targeting with clustered regularly interspaced short palindromic repeats (CRISPR) effector Cas7-11 in zebrafish embryos and mammalian cells

<title>Abstract</title> <bold>Background</bold> The CRISPR/Cas7-11 system is a recently characterized RNA editing tool that exhibits low toxicity, minimal off-target effects, and reduced collateral RNA cleavage compared with existing methods. Although zebrafish and human embryoni...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...

First-Principles Study of Cs2TlCoX6 (X = I, Br): Structural Stability, Electronic, Elastic, and Optoelectronic Properties

Abstract In this study, density functional theory (DFT) is employed to investigate the structural, electronic, and optical properties of the double perovskites Cs2TlCoX6 (X = I, Br). The crystal structures of these materials are optimized to evaluate their structural stability. T...

Artificial PhotosyntheticHydrogel Microspheres asa Versatile Platform for Programmable CO2 Valorization

Abstract Carbon-negative biomanufacturing is essential for global sustainability. Artificial photosynthesis based on material-microbe hybrid systems holds promise but suffers from inefficient energy supply, phototoxicity, abiotic–biotic incompatibility, and limited product spectr...

Population genomics reveals ginseng domestication and ginsenoside biosynthesis

Ginseng ( Panax ginseng ), a valuable medicinal plant, is cultivated for the bioactive ginsenosides with cardiovascular protective effects that are abundant in its roots. However, the genetic basis of its domestication and ginsenoside variation is not fully understood. In this st...