Shenzhen Institutes of Advanced Technology

Cloud‐Native and Distributed Systems for Efficient and Scalable Large Language Models—A Research Agenda

ABSTRACT Objective Large Language Models (LLMs) are rapidly transforming artificial intelligence applications, but their unprecedented computational, memory, communication, and data‐management demands pose significant challenges to existing computing infrastructures. Traditional...

Cross-Resolution Fusion of AlphaEarth Foundations Embeddings and GF-1 Imagery via Semantic Anchor-Graph Enhancement for Litchi Orchard Extraction

Litchi is an important cash crop in China. Accurate litchi orchard extraction is crucial for agricultural management and economic development. However, litchi orchards are spectrally very similar to evergreen broad-leaved forests and are poorly resolved in medium- and low-resolut...

Diagnosing Unconditional Migration in the Snow Ablation Optimizer Through Controlled Retention Strategies

The Snow Ablation Optimizer (SAO) uses ranked solutions to generate candidates but accepts every evaluated candidate, even when it degrades its source state. We examined whether this unconditional migration rule created a systematic risk for the individuals that contributed most...

Conversion‐Controlled Poly(Ionic Liquid)/Aluminum Nitride Thermal Interface Materials with Internal Plasticization for Reliable Chip‐Level Thermal Management

ABSTRACT The increasing power densities of artificial intelligence and high‐performance computing (HPC) chips place stringent demands on thermal interface materials (TIMs), which are designed to combine efficient heat transport with interfacial conformability, stress relaxation,...

Personalized haemodynamic modelling for non-invasive quantification of arterial stiffness in the human vasculature

Arterial stiffness is a pivotal predictor of cardiovascular events, yet its in vivo characterization remains elusive because arterial wall mechanics cannot be directly measured. Conventional inverse approaches require high-resolution imaging to resolve wall motion, restricting th...

Non‑monotonic reorganization of cortical neuron firing despite ongoing delta‑dominated activity

Delta - dominated activity is a hallmark of anesthesia and non‑REM sleep, yet how neuronal firing evolves across these rhythms remains unclear. Here, by tracking cortical neuron firing in the ketamine‑xylazine model, we find that across continuing delta - dominated activity, popu...

An automated operon refactoring workflow for heterologous expression of non-ribosomal peptide biosynthetic gene clusters

Microbial genomes encode numerous biosynthetic gene clusters, yet most remain experimentally uncharacterized, particularly large non-ribosomal peptide synthetase (NRPS) clusters that resist conventional cloning. Existing refactoring approaches are labor-intensive, depend on de no...

Graphene-Like-Armored Nanosheet Assemblies toward Fast and Stable High-Mass-Loading Sodium Storage

Abstract Sodium-ion batteries represent promising energy storage devices, yet their deployment is severely hampered by sluggish ion-transport kinetics and unstable electrode–electrolyte interfacial chemistry that deteriorate rate capability and cycling lifespan, particularly unde...

QCFSNet: A Quaternion-Guided Inter-Channel and Frequency-Spatial Feature Interaction Strategy for Endoscopic Image Segmentation

In the field of medical consumer electronics, particularly in cervical cancer diagnostics, endoscopic imaging is often affected by uneven illumination and the high similarity in textures and features between lesion regions and surrounding tissues, which severely hinders accurate...

In Situ Formation of a Hybrid Alloy‐Fluoride Interphase for Stable High‐Capacity Phosphorus Anodes

ABSTRACT Phosphorus‐based anodes are promising candidates for next‐generation high‐energy‐density lithium‐ion batteries owing to their high theoretical capacity. However, their practical application is severely limited by drastic volume variation and unstable solid electrolyte in...

Deuterium Magnetic Resonance Imaging Tracking of Deuterium Gas Releasing from Microneedle Patches for Wound Healing as a Stable Isotope Analogue of Hydrogen Gas Therapy

Abstract Hydrogen gas therapy has attracted considerable attention for the treatment of oxidative stress-related diseases owing to its excellent biosafety, selective antioxidant activity, and anti-inflammatory effects. However, its small molecular size, rapid diffusion, and short...

Revolutionizing drought defense: The water-plant-microbe synergy in climate-smart agriculture

Global warming-induced water scarcity threatens agricultural sustainability. While precision irrigation and microbial inoculants are recognized as effective individual strategies, their synergistic potential remains under-explored. This review synthesizes recent advances in the "...

An anoxygenic photosynthesis-inspired dual biohybrid for light-enhanced chemical production

Integrating light-harvesting materials with non-photosynthetic microbes offers a promising route to convert sunlight into chemicals. However, many existing biohybrid systems lack a clear architectural basis linking external light capture to intracellular redox processes. Inspired...

ASFV early infection dynamically remodels host chromatin architecture to evade immune responses

African swine fever (ASF), a lethal and highly contagious viral disease, continues to inflict substantial economic losses on the global swine industry. The etiological agent African swine fever virus (ASFV), a member of the nucleocytoplasmic large DNA viruses (NCLDV) family, prim...

Molecular Machine‐Driven Fluorogenic Probes for Motion–Signal Conversion and Hydrophilicity Retention in Live‐Cell Nanoscopy

ABSTRACT Traditional fluorogenic and cell‐permeable molecular probes for live‐cell nanoscopy mainly rely on structural or hydrophilicity changes to generate intracellular fluorescence signals. Here, we introduce molecular machines into fluorogenic probe design. As a proof of conc...

Bilayer Hydrogel Electrolytes Regulate Electric‐Field‐Induced Deformation in Zinc–Sodium Hybrid Batteries

ABSTRACT Hydrogels are widely used as quasi‐solid‐state electrolytes (QSEs) in batteries due to their favorable mechanical properties. However, a critical fundamental phenomenon has remained largely overlooked: the electro‐chemo‐mechanical evolution of the hydrogel under an elect...

Aberrant salience is selectively associated with ventral midbrain connectivity to the dorsal but not ventral striatum

The dorsal midbrain-striatal dopaminergic stream encodes salience in animals, while it’s unknown in humans. The midbrain-striatal dopaminergic hyperactivity is postulated to attribute aberrantly-heightened salience to ordinary stimuli, forming delusion and hallucination. While an...

Multifunctional Roles of Magnesium Ions in Modulating Bone Regeneration-Related Cells

Magnesium ions (Mg2+) play pivotal roles in bone regeneration by regulating the biological functions of multiple bone repair-related cells. However, the effective concentration ranges and optimal concentration of Mg2+ for different cell types remain incompletely defined, which li...

Weakening conjugation of organic cyclic additives towards advanced aqueous zinc-ion batteries

Aqueous zinc-ion batteries (AZIBs) offer a safe and economical option for energy storage but face zinc dendrites and parasitic reactions. Here we report 1,3,5-tris(2-hydroxyethyl) isocyanurate (THI) as an electrolyte additive that delivers environment-dependent dual-state protect...

Integrative AI-assisted modeling suggests CPPF binding at a composite α/β-tubulin interface pocket dominated by β-tubulin contacts

Microtubules are dynamic cytoskeletal polymers assembled from α / β -tubulin heterodimers. Microtubules are validated targets for novel therapeutic drugs, yet therapeutic efficacy targeting them is often compromised by multidrug resistance (MDR). 5-(3-chlorophenyl)-N-(3-pyridinyl...