Shenyang Pharmaceutical University

Therapy-induced senescence in cancer: from detection to intervention

Therapy-induced senescence (TIS) has emerged as an important contributor to treatment resistance and poor prognosis in clinical cancer therapy. Senescence initially acts as a tumor-suppressive mechanism by enforcing stable cell-cycle arrest, while the senescence-associated secret...

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies

Severe mpox virus (MPXV) infection causes immunopathological manifestations in patients. Here, we provide clinical evidence of MPXV-induced inflammation in a large patient cohort and demonstrate direct macrophage infection in skin tissues from an autopsied mpox patient. In human...

Design, Synthesis, and Biological Evaluation of Novel Tetrazole-Containing Tetrahydroisoquinoline Derivatives as Putative CYP51 Inhibitors against Candida Species

Abstract To address the need for structurally diverse tetrazole-based CYP51 inhibitors with reduced CYP inhibition liability, we designed and synthesized a series of tetrazole-tetrahydroisoquinoline derivatives. Starting from the metabolically unstable lead A33 (t1/2 = 2.89 min),...

Construction and Application of an Integrated “Chemical–Biological” Dual‐Core Quality Evaluation System for Salvia miltiorrhiza

ABSTRACT Background and Aim Practical implementation of integrated chemical–biological quality control in Traditional Chinese Medicine (TCM) remains challenging. This study used Salvia miltiorrhiza as a model to develop an exploratory integrated quality‐evaluation strategy that c...

Targeting Tumor–CAFs Crosstalk to Reverse Drug Resistance and Immunosuppression Through Cuproptosis

ABSTRACT Chemotherapy resistance and immunosuppression are the current key bottlenecks in tumor treatment. In the tumor microenvironment (TME), cancer‐associated fibroblasts (CAFs) secrete dense extracellular matrix and various immunosuppressive factors, forming a dynamic “tumor–...

Economical, Practical, and Scalable Synthetic Process Development for the Antiglaucoma Drug Omidenepag Isopropyl

Abstract Omidenepag isopropyl (OMDI) is the only marketed antiglaucoma drug that acts as a prostaglandin E receptor 2 (EP2) agonist. It exhibits high receptor-binding affinity (Ki = 3.6 nM) and potent agonistic activity (EC50 = 8.3 nM). More importantly, OMDI circumvents key limi...

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

Synthesis Strategies, Catalytic Mechanisms and Multifunctional Applications of Heterojunction Nanozymes: A Review

Abstract Heterojunction nanozymes offer unique advantages, including interface charge regulation, multivalent-state cycling, defect engineering, and enhanced field responses. These merits overcome the bottlenecks of single-component nanozymes, such as low catalytic activity, poor...

Ultrasound-activatable bacteria for biomedical applications

Bacteria have emerged as powerful therapeutic vectors owing to their intrinsic tumour tropism, genetic programmability, and living therapeutic functions. However, the trade-off between their autonomous proliferation and potential immunotoxicity restricts their clinical translatio...

Chitosan-Coated Oleuropein Nanoliposomes Enable Dose-Sparing Suppression of Serum Inflammatory Markers in a TNF-α-Induced Vascular Inflammation Model

Abstract Vascular inflammation, marked by endothelial dysfunction and overexpression of proinflammatory cytokines such as interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), is a key contributor to atherosclerosis. Oleuropein (Ole), a phenolic compound with prove...

A Pathway-Economical Synthesis Enabling Systematic Evaluation: Enantiodivergent Access to Aspidosperma Alkaloids Unlocks Divergent Antitumor Mechanisms

Abstract The difficulty in efficiently accessing to both enantiomers has long hampered the systematic evaluation of how chirality governs the bioactivity of natural products. We report a pathway-economical synthesis that addresses this challenge, unlocking enantiodivergent access...

Bacterial outer membrane vesicles encapsulating oncolytic virus for targeted nose-to-brain delivery

Oncolytic virus therapy, as an emerging anti-tumor biological therapy, has demonstrated significant therapeutic potential for brain tumors in clinical studies. However, due to the special anatomical barrier of the brain tissue, the application of oncolytic viruses is currently li...

Brain Penetration Optimization and Anti-neuroinflammation Evaluation of Potent 6-Methyl-7-azaindol-3-yl-quinazoline DYRK1A Inhibitors for Alzheimer’s Disease

Abstract Targeting dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) to regulate microglia-mediated neuroinflammation represents a promising therapeutic strategy for Alzheimer’s disease (AD). To address the limited brain penetration of our earlier lead ZJCK-6...

Design, Synthesis, and Biological Evaluation of Novel Arylethanone Oxime Ether Derivatives as Potent S1PR1 Agonists for Ulcerative Colitis Therapy

Abstract S1PR1 is a clinically validated key therapeutic target for ulcerative colitis (UC), but approved S1PR1 agonists universally suffer from the core drawback of S1PR3-mediated cardiotoxicity. Herein, we designed and synthesized multiple novel arylethanone oxime ethers-based...

A Microneedle Platform Co-loaded with Eugenol, Chlorogenic Acid, and Allopurinol for In Vivo Modulation of Pathological Crystal Formation in Experimental Gouty Arthritis

Abstract Gouty arthritis arises from pathological deposition of monosodium urate (MSU) crystals, whose interactions with surrounding tissues initiate and amplify inflammation. Here, we developed a nanoengineered microneedle (MN) platform for localized modulation of pathological c...

New Quality Productive Forces, Innovation and Total Factor Productivity: A Path to High-Quality Development Based on the Sustainability Framework

China’s transition from rapid growth to high-quality development requires pharmaceutical manufacturing to pursue productivity gains that are both innovation-driven and sustainable. New quality productive forces (NQPF)—characterized by technological innovation, optimized factor al...

Availability and equity analysis of China’s National Reimbursement Drug List-negotiated drugs: a national cross-sectional analysis

Ensuring equitable access to innovative drugs is crucial for public health. Despite the inclusion of innovative drugs on China’s National Reimbursement Drug List, disparities in availability persist across regions and healthcare facility levels. This study aims to assess the avai...

Rapid Identification of Multiple Types of Adulterated Ophiocordyceps sinensis by SEM ‐ EDS Based on Micromorphology and Elemental Analysis

As a rare and precious traditional Chinese medicine (TCM), Ophiocordyceps sinensis (O. sinensis) is plagued by various adulterants in the market due to factors such as resource scarcity, which seriously affects medication safety and clinical efficacy. Existing identification meth...

Construction and Antitumor Efficacy of an Antigen-Adjuvant Self-Carrier Spherical Peptide Nanovaccine.

central memory T cells.After antigen restimulation，the secretion levels of tumor necrosis factor-α and interferon-γ were significantly elevated，which indicated long-lasting immune memory. Conclusions A carrier-free spherical peptide nanovaccine based on the co-delivery strategy...

Cantharidin Causes Hepatotoxicity by Disrupting GSH‐Mediated Redox Homeostasis

ABSTRACT Cantharidin (CTD) possesses potent anticancer activity, whereas its prominent hepatotoxicity severely limits its clinical application. Because the detailed molecular mechanisms responsible for CTD‐triggered hepatotoxicity have not been fully elucidated, additional invest...