Sheba Medical Center

C-Reactive Protein Predicts Outcomes in HeartMate 3 Left Ventricular Assist Device Recipients

C-reactive protein (CRP) is an inflammatory biomarker with prognostic value in heart failure, but its role in HeartMate 3 (HM3) left ventricular assist device recipients is unclear. We retrospectively analyzed 188 adult HM3 recipients (2016–2025), stratified by preoperative CRP i...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Extended-Spectrum β-Lactamase-Producing Enterobacterales in Free-Roaming Cats in Israel

Amid the rising prevalence of antimicrobial resistance (AMR), attention is increasingly directed toward investigating additional factors that may contribute to or mediate its development, among which companion animals have emerged as a potential reservoir and transmission interfa...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Cosmic Radiation Dose‐Rates for Civil Aviation in the Middle East: Vertical Structure, Solar Modulation, and Comparison With Models

Abstract High‐altitude balloon measurements were conducted over southern Israel (30°35′N, 34°45′E; 850 m a.s.l., geomagnetic rigidity cutoff 10.3 GV) to characterize the vertical profiles of atmospheric ionization and radiation up to ∼35 km. Six balloon launches between October 2...

Global Efficacy of Aficamten in Nonobstructive Hypertrophic Cardiomyopathy: Results From ACACIA-HCM

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (nHCM) is associated with significant morbidity with no approved treatment. Aficamten is a cardiac myosin inhibitor targeting excess contractility and diastolic impairment, the predominant mechanism responsible for adverse ou...

Glycemic risk stratification in older adults with heart failure: the prognostic role of HbA1c in an aging society

Glycated haemoglobin (HbA1c) is central to diabetes mellitus (DM) management, but its prognostic value in older adults, aged ≥80 years, with heart failure (HF) remains uncertain. Thus, the study aimed to evaluate the association between HbA1c levels and all-cause mortality among...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

Irritable Bowel Syndrome and Allergic Diseases: A Nationwide Study of 1.5 Million Adolescents

BACKGROUND: Recent evidence suggests an increased prevalence of irritable bowel syndrome (IBS) among individuals with allergic diseases, and several biological mechanisms have been proposed. This study aims to investigate the association between IBS and allergic diseases in a lar...

Variation in cataract surgical outcomes by facility type: evidence from 168 population-based surveys in 61 countries

Background/aims To compare visual outcomes after cataract surgery between outreach camps and fixed facilities, and among government, non-governmental organisation (NGO) and private providers within fixed facilities. Methods Pooled cross-sectional analysis of 41 881 cataract-opera...

Resident autonomy in orthopedic trauma: independent femoral IMN by senior residents yields comparable outcomes to fellowship-trained surgeons

Abstract Introduction Intramedullary nailing (IMN) of femoral shaft fractures is a fundamental cornerstone procedure in orthopedic trauma and an important benchmark of resident surgical competency. While independent resident operating is essential for skill development, its safet...

Temporal dynamics of asynchronous digital learning among physicians: a real-world observational study

Abstract Background The rapid evolution of oncology requires continuous updating of clinical knowledge. Digital educational formats such as podcasts have emerged as accessible tools asynchtonous learning, however, data describing the real-world uptake of oncology-focused podcasts...

Cirrhosis Risk in Sarcoidosis Without Documented Hepatic Involvement—A Large Nationwide Population‐Based Cohort Study

ABSTRACT Background & Aims Given the likely underestimation of hepatic sarcoidosis, the aims were to evaluate long‐term cirrhosis risk in patients with sarcoidosis without documented hepatic involvement at baseline and to assess the impact of multi‐organ disease and immunomodulat...

Robotic, laparoscopic, and open nephrectomy and 30-day pulmonary morbidity: a procedure-stratified cohort study with intraoperative ventilation data

Previous studies of heterogeneous abdominal procedures have reported higher pulmonary-complication rates after robot-assisted surgery, but whether this applies to nephrectomy is uncertain. We evaluated surgical approach and 30-day postoperative pulmonary complications (PPCs) afte...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Volunteering and resilience in wartime: evidence from two population-based studies in Israel

Abstract Background Resilience is a key factor in coping with and recovering from large-scale traumatic events. Although volunteering has generally been associated with improving or maintaining resilience, evidence from wartime contexts is mixed. This study examined the associati...

A novel glyco-inflammatory healing index for risk prediction after isolated coronary artery bypass grafting: a multicenter retrospective cohort study

The Glyco-Inflammatory Healing Index (GIHI), calculated as HbA1c × C-reactive protein / albumin, integrates measures of glycemic control, systemic inflammation, and nutritional status. Its association with postoperative outcomes after isolated coronary artery bypass grafting (CAB...

Clinical and radiographic outcomes of pulpotomy in primary molars using bioceramic putty versus formocresol: a retrospective cohort study

This retrospective cohort study compared the clinical and radiographic outcomes of pulpotomy in cariously exposed primary molars treated with bioceramic putty (BCP) or formocresol (FC) in a private pediatric dental clinic in Tel Aviv, Israel. Records and radiographs of children a...

Sociodemographic bias in LLMs’ clinical decision-making for dizziness

Objective As large language models (LLMs) enter clinical decision support, concerns persist about sociodemographic bias. We assessed whether LLM recommendations for dizziness vary by patient descriptors and clinical detail. Methods We conducted a cross-randomized in-silico vignet...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...