Sheba Medical Center

Building a Specialty: Immigrant Jewish Surgeons and the Institutions of American Plastic Surgery

American plastic surgery acquired its professional society in 1931, organized principally by Jacques Maliniac of Warsaw, with Gustave Aufricht of Budapest among its founders, and its journal in 1946, established largely through the efforts of Aufricht. Both were Jewish immigrants...

Retinal Coverage of Combined Intravitreal Tamponade Agents after Pars Plana Vitrectomy Visualized with Orbital Magnetic Resonance Imaging

Purpose: To characterize the behavior of single and combined intravitreal tamponade agents using magnetic resonance imaging (MRI), with emphasis on identifying the most effective materials and postoperative positioning strategies for complex retinal detachments involving both sup...

Delays in breast cancer presentation, diagnosis, and treatment in young women

BACKGROUND: Breast cancer (BC) in young patients is often identified at later stages, which can result in poor prognosis. It is important to investigate the factors influencing care delays and how delays affect outcomes. METHODS: This study included women aged ≤40 years at diagno...

Retrograde Tibialis Anterior Artery Access as an Alternative Route for Stent-Based Endovascular Repair of Femoral Access-Site Complications

BackgroundFemoral arterial access can lead to complications, including bleeding, pseudoaneurysms, arteriovenous fistulas (AVFs), and dissections. When utilizing endovascular methods, the treatment of these complications is typically performed via contralateral femoral access. For...

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥...

Did Nationwide Mental Health Insurance Reform in Israel Increase Access to Community-Based Care?

Israel's nationwide mental health reform (July 1, 2015) transferred responsibility and funding for mental healthcare from the Ministry of Health to Israel's four Health Maintenance Organizations (HMOs), aiming to improve access and availability, integrate mental health into gener...

Prevalence and Long-Term Incidence of Ocular Manifestations in Sarcoidosis: A Large Nationwide Population-Based Study

Purpose Ocular involvement causes major vision-threatening morbidity in sarcoidosis. Population-based evidence on the full ocular spectrum, long-term incidence, and organ-specific patterns remains limited.Methods Nationwide 1:1 matched case-control study with a longitudinal retro...

A novel approach to treating Endometriosis-Related Repeated IVF failures- insights from single case report

This report explores the case of a young, normal-responder nulligravida with peritoneal endometriosis and recurrent implantation failure, with poor embryo quality during multiple failed attempts at IVF treatment. The patient underwent Dienogest (Visabelle®) pretreatment followed...

Defining Success in Ptosis Surgery: Outcome Heterogeneity and Priorities for Standardization

Ptosis surgery aims to restore eyelid position, visual function, facial expression, and, in children, visual development. Yet reported success rates reflect how success is defined as much as what surgery achieves. Studies use different eyelid-height thresholds, symmetry criteria,...

Antibody-Drug Conjugate-Associated Oral Toxicities

Aim: Antibody-drug conjugates (ADCs) are an emerging class of anti-cancer therapies, designed to specifically target cancer cells while minimizing impact on healthy tissues; however, they are associated with a broad spectrum of toxicities. The goal of this paper is to review the...

Complex, but not simple, motor tasks assessment improves detection of motor-cognitive interaction in midlife

Abstract Executive and motor function are bidirectionally linked and decline as we age, yet motor-cognitive links are predominantly studied in older adults, while studies focused on midlife report mixed results. We aimed to evaluate whether motor tasks of varying complexity refle...

Predicting measles outbreak magnitude via modeled population susceptibility evidence from pre-vaccination data

We characterized pre-vaccination measles dynamics using a discrete-time mechanistic model that integrates incidence time series and demographic data to estimate key epidemiological parameters and to quantify the relationship between the reconstructed population susceptibility and...

Metabolic heterogeneity in the risk of cancer among patients with cardiovascular diseases and diabetes

The co-occurrence of cardiovascular diseases (CVDs) and cancer may worsen patient outcomes and burden the healthcare system. We aimed to evaluate metabolic patterns of cancer risk and to characterize the heterogeneity of such an association across cancer and CVD subtypes. We anal...

Myocardial late gadolinium enhancement is strongly associated with ventricular arrhythmias in mitral valve prolapse

The prognosis of patients with mitral valve prolapse (MVP) largely depends on the presence of ventricular arrhythmias. This study aims to identify association between Cardiac MRI (CMR) based findings with ventricular arrhythmias in MVP patients. Consecutive patients (n = 45, mean...

Two-Year Clinical Outcomes of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression

OBJECTIVES: To assess 24-month clinical outcomes of vagus nerve stimulation (VNS) in individuals with higher-grade treatment-resistant depression (HG-TRD) treated within a national open-label program, focusing on depressive severity, suicidality, safety, tolerability, and rates o...

Telerehabilitation for Motor Recovery in Adults with Neurological Disorders: A Systematic Review and Meta-Analysis Across Motor Domains, Delivery Models, and Follow-Up Effects

Background/Objectives: Telerehabilitation may extend neurorehabilitation beyond conventional settings, but comparative effects across neurological diagnoses and motor domains remain uncertain. This systematic review and meta-analysis synthesized motor outcomes while distinguishin...

Herpesviridae Reactivation and Therapeutic Outcomes in Patients with Ulcerative Colitis Treated with Tofacitinib

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Historically, anti-tumor necrosis factor (TNFα) agents have been the mainstay of biological therapy. Recently, Janus kinase inhibitors (JAK-I) have emerged as oral alternatives. However, despite their ac...

National HBsAb serosurvey and HBsAg/Hepatitis D coinfection prevalence across sociodemographic and immigrant populations in Israel

Abstract Background Hepatitis B virus (HBV) remains a global health burden despite widespread vaccination efforts. This nationwide serosurvey aimed to assess Hepatitis B surface antibody (HBsAb) seropositivity in Israel and HBV/ Hepatitis D virus (HDV) prevalence among immigrant...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...