Sheba Medical Center

Cirrhosis Risk in Sarcoidosis Without Documented Hepatic Involvement—A Large Nationwide Population‐Based Cohort Study

ABSTRACT Background & Aims Given the likely underestimation of hepatic sarcoidosis, the aims were to evaluate long‐term cirrhosis risk in patients with sarcoidosis without documented hepatic involvement at baseline and to assess the impact of multi‐organ disease and immunomodulat...

Robotic, laparoscopic, and open nephrectomy and 30-day pulmonary morbidity: a procedure-stratified cohort study with intraoperative ventilation data

Previous studies of heterogeneous abdominal procedures have reported higher pulmonary-complication rates after robot-assisted surgery, but whether this applies to nephrectomy is uncertain. We evaluated surgical approach and 30-day postoperative pulmonary complications (PPCs) afte...

Defining global priorities in hematopoietic transplantation and cellular therapy: a statement paper from EBMT Global ComMittee

Abstract Hematopoietic cell transplantation, cellular and gene therapies, and (CAR)-T cells have revolutionized outcomes in hematologic disorders. However, major disparities persist in their availability, accessibility, and affordability, particularly in low- and middle-income co...

Volunteering and resilience in wartime: evidence from two population-based studies in Israel

Abstract Background Resilience is a key factor in coping with and recovering from large-scale traumatic events. Although volunteering has generally been associated with improving or maintaining resilience, evidence from wartime contexts is mixed. This study examined the associati...

A novel glyco-inflammatory healing index for risk prediction after isolated coronary artery bypass grafting: a multicenter retrospective cohort study

The Glyco-Inflammatory Healing Index (GIHI), calculated as HbA1c × C-reactive protein / albumin, integrates measures of glycemic control, systemic inflammation, and nutritional status. Its association with postoperative outcomes after isolated coronary artery bypass grafting (CAB...

Clinical and radiographic outcomes of pulpotomy in primary molars using bioceramic putty versus formocresol: a retrospective cohort study

This retrospective cohort study compared the clinical and radiographic outcomes of pulpotomy in cariously exposed primary molars treated with bioceramic putty (BCP) or formocresol (FC) in a private pediatric dental clinic in Tel Aviv, Israel. Records and radiographs of children a...

Sociodemographic bias in LLMs’ clinical decision-making for dizziness

Objective As large language models (LLMs) enter clinical decision support, concerns persist about sociodemographic bias. We assessed whether LLM recommendations for dizziness vary by patient descriptors and clinical detail. Methods We conducted a cross-randomized in-silico vignet...

Multicenter retrospective study on perceived effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome

22q11.2 deletion syndrome (22q11DS) markedly increases risk of psychiatric disorders, including anxiety and mood disorders, and is associated with a spectrum of cognitive impairment, from borderline functioning to intellectual disability, with cognitive decline frequently reporte...

A pharmacometric framework for norepinephrine transporter occupancy and dose equivalence across psychotropic medications

Background: Norepinephrine transporter (NET) inhibition is a relevant mechanism across psychotropic medications, although prescribing classifications are largely based on drug class rather than quantitative target engagement. Aims: To facilitate cross-drug comparisons of noradren...

Understanding temporal changes in intrinsic capacity: analysis of domain-specific intrinsic capacity using SHARE data

Global population aging challenges acute, disease-centric healthcare models and highlights the need for functional markers of aging. The World Health Organization's intrinsic capacity (IC) framework, encompassing cognition, vitality, locomotion, psychological well-being, and sens...