Shanghai University of Traditional Chinese Medicine

T9. BRAIN–BONE CROSSTALK IN SCHIZOPHRENIA-ASSOCIATED OSTEOPOROSIS: FROM BRAIN-CENTERED THERAPY TO BRAIN–BONE CO-TREATMENT

Background Schizophrenia is increasingly recognized as a systemic disorder rather than a purely brain-centered psychiatric disease. Osteoporosis and fragility fractures are underrecognized but clinically important comorbidities in patients with schizophrenia, who often show reduc...

Population Pharmacokinetics of Topical Timolol Maleate Gel in Healthy Volunteers and Infants With Superficial Infantile Hemangioma

Although timolol ophthalmic solutions or hospital-compounded formulations have been used off-label for the treatment of superficial infantile hemangioma (IH), no topical timolol formulation has been developed specifically for this indication. This study was the first to develop a...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Biotin‐Engineered Phenothiazine Photosensitizer Boosts Type I Photodynamic Therapy via Singlet‐Excited‐State Electron Transfer

Comprehensive Summary Type II‐dominant photosensitizers often suffer from reduced photodynamic efficacy under tumor hypoxia. We report a biotin‐modified phenothiazine photosensitizer termed DHU‐Blue‐7, which converts type II methylene blue (MB)‐like photosensitization into a type...

Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea

ABSTRACT This study aimed to elucidate the key mechanisms underlying short stature with pediatric persistent diarrhea in children (PDC) and to propose an integrated model linking the butyrate-producing gut microbial niche, short-chain fatty acids (SCFAs), Th17/Treg balance, the g...

Natural product-derived compounds modulating STAT3 signaling in prostate cancer: Mechanistic insights and therapeutic potential

Prostate cancer (PCa) is a major malignancy in men and current treatment options remain limited by therapeutic resistance and treatment-related toxicity. Signal transducer and activator of transcription 3 (STAT3) is a key regulator of PCa progression and an attractive therapeutic...

The Lactate–Lactylation Axis as a Metabolic–Epigenetic Framework for Therapeutic Adaptation in Esophageal Squamous Cell Carcinoma

Therapeutic failure in esophageal squamous cell carcinoma (ESCC) can arise as tumor cells and their microenvironment adapt to sustained treatment pressure. The lactate–lactylation axis may connect altered metabolism with adaptive treatment responses through changes in protein and...

m⁶A-dependent TRIM71 stabilization by YTHDC1 promotes hepatoblastoma progression

Abstract Hepatoblastoma (HB) is the most common primary malignant liver cancer in children. Although complete surgical resection and standardized chemotherapy remain the most effective treatments for HB, they are not curative for all patients. Therefore, a deeper understanding of...

MSH5 Gene Polymorphisms Are Associated with Hashimoto’s Thyroiditis Susceptibility in a Chinese Han Population

Background This study investigated associations between MSH5 polymorphisms and autoimmune thyroid disease (AITD) susceptibility.Methods We genotyped rs409558 and rs707939 in 943 patients with AITD, including 591 with Graves’ disease (GD) and 352 with Hashimoto’s thyroiditis (HT),...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Effect of Photobiomodulation‑Based LED on Myopia Control in Children: An Exploratory Randomized Clinical Trial

Laser-based repeated low-level red-light (RLRL) therapy may slow myopia progression, but evidence for lower-intensity noncoherent photobiomodulation-based light-emitting diode (PBM-LED) therapy remains limited. We evaluated its short-term efficacy and safety in children with myop...

Integrative Traditional Chinese Medicine Approaches for Plasma Cell Mastitis: Clinical Efficacy and Mechanistic Insights—A Narrative Review

Background Plasma cell mastitis (PCM) is a chronic nonlactational inflammatory breast disease characterized by recurrent inflammation, abscesses, sinus tracts, fibrosis, and high recurrence risk. Current treatments mainly target symptoms and complications but may not fully addres...

Integrated machine learning and clinical validation identify COL21A1 as a potential biomarker for sarcopenia

Sarcopenia is a progressive skeletal muscle disorder characterized by loss of mass, strength, and function. However, reliable molecular biomarkers for early detection remain limited. This study aimed to identify and validate potential biomarkers for sarcopenia through a combinati...

Computed tomography portal venous reconstruction assisted endoscopic ultrasound-guided selective inflow vessel devascularization for the treatment of type 1 gastroesophageal varices

EUS-guided combination therapy (coil and hemostatic glue) for bleeding and non-bleeding gastric varices has recently attracted considerable attention after promising results were published in multiple small studies. We performed a meta-analysis to investigate the safety and effic...

Role and diagnostic value of miR-3188 targeting OGT in regulating osteoblast function in delayed fracture healing of tibial fractures

This study investigated the role and mechanism of miR-3188 in delayed healing of tibial fractures, aiming to aid diagnosis and targeted intervention. A total of 172 patients with tibial fracture were enrolled and divided into normal fracture healing group (NFH, n = 82) and DFH (...

Amino Acid Metabolism in Health and Disease

ABSTRACT Metabolic reprogramming is a central feature of many human diseases, and therapies that target altered metabolic dependencies are moving from concept to clinical testing. Amino acid homeostasis links essential and nonessential amino acid supply with branched‐chain amino...

Atractylodis Rhizoma-derived nanovesicles suppress adipocyte IDO1/kynurenine-AhR-androgen receptor signaling in a mouse model of obesity-associated PCOS

Abstract Background Obesity-associated polycystic ovary syndrome (PCOS) is characterized by metabolic dysfunction, adipose inflammation and androgen excess, but the adipose mechanism linking metabolic stress to androgen-related pathology remains unclear. This study aimed to deter...

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures asso...

Metrnl Reduces Thrombosis and Acute Myocardial Injury Through Inhibition of Platelet Activation via CD36 Receptor Degradation

BACKGROUND: Metrnl (Meteorin-like) is a secreted protein that plays a pivotal role in regulating insulin sensitivity, angiogenesis, and atherosclerosis. The circulating Metrnl levels are mainly derived from the endothelium and associated with atherosclerosis and arterial thrombot...