Shanghai University of Traditional Chinese Medicine

Association Between Traditional Chinese Medicine Syndromes and Depression Severity in Glaucomatous Optic Atrophy: Therapeutic Implications of Integrated TCM Interventions

Objective This study aimed to clarify how the holistic traditional Chinese medicine (TCM) pattern, based on ocular and systemic findings in patients with glaucomatous optic atrophy, correlates with depression severity and evaluate the therapeutic impact of integrated TCM interven...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

Acupuncture and Moxibustion for Neck Pain: A Clinical Practice Guideline

ABSTRACT Background Neck pain (NP) is a leading cause of disability worldwide. Pharmacological treatments often provide limited benefits and may be associated with adverse effects, highlighting the need for effective non‐pharmacological options. Aim To develop evidence‐based reco...

Persistent Hypoperfusion on Post‐Recanalization Digital Subtraction Angiography Perfusion Maps in Anterior Circulation Large Vessel Occlusion

Background Despite high recanalization rates with endovascular thrombectomy for large vessel occlusion stroke, a large proportion of patients remain disabled. This study aims to investigate the clinical impact of persistent hypoperfusion that was detected immediately after recana...

Protective effects of icariin in atherosclerotic cardiovascular disease: mechanistic basis, post-ischemic protection and translational limitations

CONTEXT: Icariin (ICA), a prenylated flavonol glycoside from Epimedii Folium, has been investigated in experimental models relevant to atherosclerosis, myocardial infarction, and ischemic tissue injury. OBJECTIVES: This review evaluates experimental evidence on ICA in atheroscler...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Iron deficiency-related abortion and miscarriage burden among women of advanced maternal age

Advanced maternal age (AMA) is associated with reduced fertility and higher risks of adverse pregnancy outcomes. Iron deficiency, a leading cause of anemia, has been associated with pregnancy loss. However, the iron deficiency-related burden among AMA women remains poorly quantif...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

Association between hippocampal ferroptosis-related changes and behavioral alterations in CCI rats with neuropathic pain

This study aimed to characterize behavioral alterations induced by chronic constriction injury (CCI) of the sciatic nerve and hippocampal ferroptosis in rats and to explore the association between hippocampal ferroptosis and behavioral changes accompanying neuropathic pain (NP)....

From baseline levels to cumulative exposure and longitudinal trajectories: estimated glucose disposal rate and incident cardiometabolic multimorbidity among middle-aged and older adults in the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS)

Abstract Background Insulin resistance is implicated in the development of cardiometabolic multimorbidity (CMM), but evidence regarding the associations of baseline, cumulative, and longitudinal patterns of estimated glucose disposal rate (eGDR) with incident CMM remains limited....

Fungal Phosphatase-Dependent Induction of Host Cell Pyroptosis by Candidalysin

Abstract Fungal infections pose a major public health threat and can cause host cell damage through diverse forms of regulated cell death. However, our understanding of how fungal pathogens interact with host to elicit pyroptosis remains in its infancy. Here, we show that candida...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Construction and Application of an Integrated “Chemical–Biological” Dual‐Core Quality Evaluation System for Salvia miltiorrhiza

ABSTRACT Background and Aim Practical implementation of integrated chemical–biological quality control in Traditional Chinese Medicine (TCM) remains challenging. This study used Salvia miltiorrhiza as a model to develop an exploratory integrated quality‐evaluation strategy that c...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

The clinicopathological significance and mechanisms of interstitial foam cells formation in patients with primary membranous nephropathy

Accumulation of foam cells (FCs) in interstitium is frequently observed in membranous nephropathy (MN). However, the pathophysiological significance of those cells remains poorly understood. It is generally accepted that interstitial FCs are derived from macrophages with lipid de...

Structural characterization of an RG-II-associated complex pectic polysaccharide from Typha angustifolia pollen with dendritic cell-modulating activity

BACKGROUND: Pectic polysaccharides from medicinal plants are promising natural immunomodulators, but their structural heterogeneity has hindered the identification of bioactive domains and limited their further development. The structural basis underlying their regulation of dend...

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

ABSTRACT Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome‐targeting receptors (LTRs) to redirect extracellular and membrane proteins for lysosomal degradation. Expanding the repertoire of clinically relevant LTRs could broaden the therapeutic p...

Stabilizing Macrophage Immune States through Fusion-Enabled Nanoparticle-Based Intracellular Drug Depots for Durable Ulcerative Colitis Therapy

Abstract Ulcerative colitis (UC) is characterized by persistent colonic inflammation accompanied by the accumulation of pro-inflammatory M1-like macrophages, which sustain cytokine production and impair mucosal repair. Promoting a shift toward a pro-resolving M2-like phenotype is...

From art to metrics: a closed-loop framework for quantifying dose, manipulation, and feedback

Abstract The clinical effects of acupuncture depend heavily on its physical parameters, particularly treatment dose and needling technique. Yet these parameters are still poorly standardized in both research and clinical settings. This reproducibility, hinders interpretation of f...